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Endodontology - Root canal treatment and root-filled teeth

Research group
Active research
Project owner
Institutionen för odontologi

Short description

Approximately 250,000 receive a root-filling annually in Sweden. The evidence in diagnosis and treatment is deficient, but the overall picture is that root canal treatment effectively cure toothache and that the majority of the root-filled teeth can be retained for a long time. Epidemiological studies, however, show that many root-filled teeth have a, usually asymptomatic, persistent inflammation in the surrounding tissues adjacent to the root. Our research goals are to generate better knowledge about root canal treatment and;

• Investigate the effectivity of different parts of the root canal treatment procedure
• Estimate benefits and cost-effectiveness of root canal treatment
• Evaluate risks and effects of chronic inflammation due to root-filled teeth
• Explore relationship between tooth damage, root canals and systemic disease

Root canal treatment in general dental care

Studies on indications, costs and results
Despite the fact that dental health in Sweden has improved, root canal treatments are a common measure in general dental care. Statistics from the Swedish Social Insurance Agency show that in 2010, 250,000 new root fillings were registered. Root canal treatment, which involves a mechanical and chemical disinfection of a tooth's root canals, is often technically complicated, time consuming and is often experienced as difficult by general dentists. Root canal treatments have been evaluated in terms of tooth survival and maintenance or establishment of healthy periradicular conditions. Follow-ups have primarily been performed at universities and specialist clinics. Dental survival is generally high and has been estimated at 85–90% over a 10-year period. Optimally performed root canal treatments result in healthy periradicular tissues in 85–95% of cases. However, in epidemiological studies, signs of infection and inflammation in root-filled teeth are common. In Scandinavian populations, the frequency varies between 25–50%.

Prospective cohort studies of root canal treatments performed in general dental care are almost completely lacking and the need for such has been pointed out by both the Swedish Agency for Medical Evaluation (SBU) and the National Board of Health and Welfare. In addition, the importance of clinical research for root canal treatment prevention has been emphasized.

The overall goal of this prospective cohort study carried out in collaboration with Folktandvården in Västra Götaland is to generate better knowledge about root canal treatment in Swedish public dental care and in particular to estimate the costs, evaluate the benefits and examine the outcome of root canal treatments performed in general practice.

Project Facts

Project Manager
Thomas Kvist & Emma Wigsten

Funding
+ Folktandvården
+ TUA-funds (VGR)

Collaboration
+ EndoReco (Endodontic Research Collaboration)
+ Department of Health, Medicine and Caring Sciences, Linköping University

Endodontic status and cardiovascular disease

Smoking, diabetes and obesity are well known risk factors for cardiovascular disease. It is also well known that chronic inflammatory processes are involved in the development of atherosclerosis.

The contribution of endodontic inflammatory processes has been debated for more than a hundred years, but the discussion rests on a fragile scientific basis. A quarter of a million root canals are performed in Sweden every year. Most due to deep caries and with inflammation in the pulp or in the periapical tissue. The majority of adult Swedes have at least one root-filled tooth. Epidemiological studies show persistent chronic inflammation in root-filled teeth in approximately 25% of cases. This means that about 30% of the population has at least one tooth with apical periodontitis.

On a somewhat firmer foundation rests the connection between marginal periodontitis and cardiovascular disease. A Swedish case-control study (PAROKRANK) of 805 patients who fell ill with their first heart attack found an increased risk (OR 1.28) of a first heart attack in individuals with periodontitis.

With access to panoramic X-rays from the Parokrank study, we now have the opportunity to significantly improve the state of evidence regarding a possible connection between endodontic inflammatory processes and cardiovascular disease. In our project, we will measure parameters that in different ways represent infection and inflammation in pulp and periapical tissue (caries, filling therapy, root fillings and apical periodontitis) with existing X-rays of patients and controls enrolled in the PAROKRANK project.

Project Facts

Project Manager
Thomas Kvist

Funding
+ Folktandvården
+ TUA-medel (VGR)
+ European Society of Endodontology

Collaboration
+ Karolinska Institutet
+ EndoReco (Endodontic Research Collaboration)

Can chronic asymptomatic apical periodontitis of root-filled teeth be left untreated and can clinical risk factors for an emergency be identified?

There are approximately 10 million root-filled teeth in Sweden alone, of which 25% have signs of persistent infection and inflammation, apical periodontitis. In most cases, the condition is chronic and asymptomatic. But it happens that the inflamed area in the jaw enlarges or that the patient suddenly develops swelling and pain. There is great variation and disagreement about how a symptom-free root-filled tooth with apical periodontitis should be treated. The National Board of Health and Welfare's national guidelines for adult dental care assess the condition to have a moderate effect on oral health and give the condition a relatively low priority (6 on a scale 1-10). From an academic point of view, it has been more or less an axiom that these teeth should be treated. In specialist clinics for endodontics, treatment of root-filled teeth occupies approximately 50% of the clinical time. Treatment is associated with costs in the order of 5000-20000 kronor. The patients who have subjective problems from their root-filled tooth obviously need to have the condition cured or remedied. For those who are asymptomatic, however, the necessity of treatment is questioned.

The purpose of this project is to systematically and prospectively investigate whether asymptomatic root-filled teeth with signs of apical periodontitis can be left without action without significant risk of symptoms or deterioration (increasing part of the surrounding tissues involved) and to identify risk factors for such adverse events. The results can possibly lead to that the number of time-consuming and costly root canal retreatments or tooth extractions can be reduced.

Project Facts

Project Manager
Thomas Kvist

Funding
+ Folktandvården
+ TUA-medel (VGR)