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- Carmen Corciulo
Carmen Corciulo
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Sektionen för farmakologiOm Carmen Corciulo
The research group is led by Dr. Carmen Corciulo. She graduated from the University of Ferrara with an MSc degree in Molecular Biology, and in 2014 she received a PhD in Molecular Pharmacology from the same university. After her PhD, she took on a postdoctoral position at New York University – Division of Translational Medicine (New York, USA). In 2019 she started a new post-doc position at the Department of Rheumatology and in 2021-2022 she was a Marie-Curie's postdoctoral fellow.
In 2023 she established her laboratory at the Department of Pharmacology at the Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg.
Sex differences in osteoarthritis pain: exploring the pain perception in male and female subjects
Alterations of articular cartilage function and tissues surrounding the joint can lead to osteoarthritis, in which mild inflammation plays a key role by activating and sustaining the production of catabolic factors responsible for cartilage degradation. OA is characterized by inflammation of the synovial membrane, loss of articular cartilage and trabecular subchondral bone, and thickening of the cortical subchondral bone with the formation of bony outgrowths called osteophytes.
OA is one of the most common causes of chronic pain in Europe. Pain in OA is a complex phenomenon, attributable to different independent mechanisms that interact with each other. These include the following: (1) local processes around the joint involving the thickness of the synovial membrane and alteration of the subchondral bone, localized under the articular cartilage; (2) neuronal mechanisms, such as major innervation of the joint tissues and reduction of the pain threshold, which lead to increased responsiveness of the peripheral nerve to non-noxious stimuli; and (3) genetic components and co-morbidities such as obesity and diabetes, which contribute to the pain sensitivities. Pain also has a strong social and emotional component.
The research activities in Carmen’s group aim to uncover the biological differences behind the different pain sensitivity in male and female patients with OA.
Why our research is important?
- Chronic pain and reduced mobility are associated with anxiety, depression, and a general poor life quality. Currently, the therapeutic strategies available are not able to block or revert the progression of the disease and pain relievers come with important side effects and work for a limited time.
- Women with musculoskeletal diseases, OA among them, take more sick leave than men creating differences in career opportunities and gender inequity.
- Data about pain in OA will pave the way for understanding pain mechanisms in other diseases involving the bone, like osteoporosis and bone cancer.
Research strategies
1 – Define the role of ovarian hormones in the physiologic mechanisms that, if disrupted, will lead to bone damage, joint inflammation, and triggering of pain in pre-clinical models;
2- Test the efficacy of a new therapeutic approach in preventing joint damage in an OA mouse model;
3- Identify sex differences in osteoarthritis patients and their link to the pain intensity.
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Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG
Sialylation.
Priti Gupta, Tibor Sághy, Miriam Bollmann, Tao Jin, Claes Ohlsson, Hans Carlsten, Carmen Corciulo, Cecilia Engdahl
Vaccines - 2024 -
Role of estrogen signaling in fibroblastic reticular cells for innate and adaptive immune responses in antigen-induced
arthritis
Aidan Barrett, Karin Horkeby, Carmen Corciulo, Hans Carlsten, Marie K Lagerquist, Julia Scheffler, Ulrika Islander
IMMUNOLOGY AND CELL BIOLOGY - 2024 -
Physiological estrogen levels are dispensable for the sex difference in immune responses during allergen-induced airway
inflammation
Aidan Barrett, Piotr Humeniuk, Christina Drevinge, Carmen Corciulo, Julie Weidner, Madeleine Rådinger, Hans Carlsten, Julia M. Scheffler, Ulrika Islander
Immunobiology - 2023 -
Profiling of innate and adaptive immune cells during influenza virus infection reveals sex bias in invariant natural killer T (iNKT)
cells
Piotr Humeniuk, Aidan Barrett, Hannes Axelsson, Carmen Corciulo, Christina Drevinge, Alicia M. del Carpio Pons, Davide Angeletti, Julia M. Scheffler, Ulrika Islander
Immunity, Inflammation and Disease - 2023 -
Physiological levels of estradiol limit murine osteoarthritis
progression
Carmen Corciulo, Julia M. Scheffler, Piotr Humeniuk, Alicia M. del Carpio Pons, Alexandra Stubelius, U. Von Mentzer, Christina Drevinge, Aidan Barrett, Sofia Wüstenhagen, Matti Poutanen, Claes Ohlsson, Marie K Lagerquist, Ulrika Islander
Journal of Endocrinology - 2022 -
Reduction of Mature B Cells and Immunoglobulins Results in Increased Trabecular
Bone
Marie K Lagerquist, P. Gupta, E. Sehic, Karin L Horkeby, Julia M. Scheffler, Jauqueline Nordqvist, Lina Lawenius, Ulrika Islander, Carmen Corciulo, Petra Henning, Hans Carlsten, Cecilia Engdahl
Jbmr Plus - 2022 -
ER alpha Signaling in a Subset of CXCL12-Abundant Reticular Cells Regulates Trabecular Bone in
Mice
Julia M. Scheffler, Karin L. Gustafsson, Aidan Barrett, Carmen Corciulo, Christina Drevinge, Alicia M. del Carpio Pons, Piotr Humeniuk, Cecilia Engdahl, J. A. Gustafsson, Claes Ohlsson, Hans Carlsten, Marie K Lagerquist, Ulrika Islander
JBMR Plus - 2022 -
Biomaterial Integration in the Joint: Pathological Considerations, Immunomodulation, and the Extracellular
Matrix.
Ula von Mentzer, Carmen Corciulo, Alexandra Stubelius
Macromolecular bioscience - 2022 -
Rapamycin Dampens Inflammatory Properties of Bone Marrow ILC2s in IL-33-Induced Eosinophilic Airway
Inflammation
Emma Boberg, Julie Weidner, Carina Malmhäll, Jenny Calvén , Carmen Corciulo, Madeleine Rådinger
Frontiers in Immunology - 2022 -
Adenosine A2A receptor null chondrocyte transcriptome resembles that of human osteoarthritic
chondrocytes
C. M. Castro, Carmen Corciulo, B. Friedman, Z. Li, S. Jacob, D. Fenyo, B. N. Cronstein
Purinergic Signalling - 2021 -
Pulsed administration for physiological estrogen replacement in
mice
Carmen Corciulo, Julia M. Scheffler, Karin L. Gustafsson, Christina Drevinge, Piotr Humeniuk, Alicia M. del Carpio Pons, Matti Poutanen, Claes Ohlsson, Marie K Lagerquist, Ulrika Islander
F1000Research - 2021 -
Signaling of the Purinergic System in the
Joint
Carmen Corciulo, B. N. Cronstein
Frontiers in Pharmacology - 2020 -
Interleukin 17A: a Janus-faced regulator of
osteoporosis
Julia M. Scheffler, Louise Grahnemo, Cecilia Engdahl, Christina Drevinge, Karin L. Gustafsson, Carmen Corciulo, Lina Lawenius, Y. Iwakura, Klara Sjögren, Marie Lagerquist, Hans Carlsten, Claes Ohlsson, Ulrika Islander
Scientific Reports - 2020