Malin Johansson

• The structure of FCGBP is formed as a disulfide-mediated homodimer between its C-terminal domains

  Erik Ehrencrona, Pablo Gallego, Sergio Trillo-Muyo, Maria-Jose Garcia-Bonete, Christian V Recktenwald, Gunnar C. Hansson, Malin E V Johansson
  FEBS JOURNAL - 2025
• Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.

  Paola Paone, Dimitris Latousakis, Romano Terrasi, Didier Vertommen, Ching Jian, Valentina Borlandelli, Francesco Suriano, Malin E V Johansson, Anthony Puel, Caroline Bouzin, Nathalie M. Delzenne, Anne Salonen, Nathalie Juge, Bogdan I. Florea, Giulio G. Muccioli, Herman Overkleeft, Matthias Van Hul, Patrice D. Cani
  Gut - 2024
• GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota

  Thomas U. Greiner, Ara Koh, Eduard Peris, Mattias Bergentall, Malin E V Johansson, Gunnar C. Hansson, Daniel J. Drucker, Fredrik Bäckhed
  MOLECULAR METABOLISM - 2024
• The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based cross-linking

  Christian V Recktenwald, Göran Karlsson, Maria-Jose Garcia-Bonete, Gergely Katona, Maja Jensen, Richard Lymer, Malin Bäckström, Malin E V Johansson, Gunnar C. Hansson, Sergio Trillo-Muyo
  Cell Reports - 2024
• Low-grade intestinal inflammation two decades after pelvic radiotherapy.

  Sravani Devarakonda, Annika Thorsell, Per Hedenström, Azar Rezapour, Lisen Heden, Sanghita Banerjee, Malin E V Johansson, George M. H. Birchenough, Amelie Toft Morén, Karin Gustavsson, Viktor Skokic, Victor Pettersson, F. Sjöberg, Marie Kalm, Mohammad Al Masri, Michaela Ekh, Henrik Fagman, Mats Wolving, Rosie Perkins, Rodrigo A Morales, Francisca Castillo, Eduardo J Villablanca, Ulf Yrlid, Karin Bergmark, Gunnar Steineck, Cecilia Bull
  EBioMedicine - 2023
• The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins

  Pablo Gallego, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Christian V Recktenwald, Malin E V Johansson, Gunnar C. Hansson
  Nature communications - 2023
• The role of goblet cells and mucus in intestinal homeostasis

  Jenny K Gustafsson, Malin E V Johansson
  Nature Reviews Gastroenterology & Hepatology - 2022
• Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection

  D. P. Yang, A. Jacobson, K. A. Meerschaert, J. J. Sifakis, M. Wu, X. Chen, T. D. Yang, Y. L. Zhou, P. V. Anekal, R. A. Rucker, D. Sharma, A. Sontheimer-Phelps, G. S. Wu, L. W. Deng, M. D. Anderson, S. Choi, D. Neel, N. C. L. Lee, D. L. Kasper, B. Jabri, J. R. Huh, Malin E V Johansson, J. R. Thiagarajah, S. J. Riesenfeld, I. M. Chiu
  Cell - 2022
• Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport

  Brendan Dolan, Anna Ermund, Beatriz Martinez Abad, M Johansson, Gunnar C. Hansson
  Science Signaling - 2022
• Human intelectin-2 (ITLN2) is selectively expressed by secretory Paneth cells

  E. B. Nonnecke, P. A. Castillo, Malin E V Johansson, E. J. Hollox, B. Shen, B. Lönnerdal, C. L. Bevins
  FASEB Journal - 2022
• A fiber-rich diet and radiation-induced injury in the murine intestinal mucosa

  Dilip Malipatlolla, Sravani Devarakonda, Piyush Patel, Fei Sjöberg, A. Rascón, Rita Grandér, Viktor Skokic, Marie Kalm, Jolie Danial, Eva Mehdin, Malin Warholm, Henrietta Norling, A. Stringer, Malin E V Johansson, M. Nyman, Gunnar Steineck, Cecilia Bull
  International Journal of Molecular Sciences - 2022
• Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer

  Jack D. A. Sharpen, Brendan Dolan, Elisabeth E. L. Nyström, George M. H. Birchenough, Liisa Arike, Beatriz Martinez Abad, Malin E V Johansson, Gunnar C. Hansson, Christian V Recktenwald
  Nature Communications - 2022
• Human intelectin-1 (ITLN1) genetic variation and intestinal expression

  E. B. Nonnecke, P. A. Castillo, A. E. Dugan, F. Almalki, M. A. Underwood, C. A. De La Motte, W. Yuan, W. Lu, B. Shen, Malin E V Johansson, L. L. Kiessling, E. J. Hollox, B. Lonnerdal, C. L. Bevins
  Scientific Reports - 2021
• The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds

  Erik Ehrencrona, Sjoerd van der Post, Pablo Gallego, Christian V Recktenwald, Ana Rodriguez-Piñeiro, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Malin Bäckström, Gunnar C. Hansson, Malin E V Johansson
  Journal of Biological Chemistry - 2021
• An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

  Elisabeth E. L. Nyström, Beatriz Martinez Abad, Liisa Arike, George M. H. Birchenough, E. B. Nonnecke, P. A. Castillo, Frida Svensson, C. L. Bevins, Gunnar C. Hansson, Malin E V Johansson
  Science - 2021
• Forming a mucus barrier along the colon

  George M. H. Birchenough, Malin E V Johansson
  Science - 2020
• Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota

  Liisa Arike, A. Seiman, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E V Johansson, Gunnar C. Hansson
  Cell Reports - 2020
• The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

  Joana K. Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz Martinez Abad, Björn O. Schröder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E V Johansson, Gunnar C. Hansson, George M. H. Birchenough
  Journal of Experimental Medicine - 2019
• Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells

  Sinan Sharba, Nazanin Navabi, Médea Padra, Macarena P Quintana-Hayashi, Jenny K Gustafsson, Louis Szeponik, Vignesh Venkatakrishnan, A. Sjoling, Staffan Nilsson, Marianne Quiding-Järbrink, Malin E V Johansson, Sara K. Lindén
  Virulence - 2019
• Normal calcium-activated anion secretion in a mouse selectively lacking TMEM16A in intestinal epithelium

  Génesis Vega, Anita Guequén, Malin E V Johansson, Liisa Arike, Beatriz Martinez Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
  Frontiers in Physiology - 2019
• Potential roles of gut microbiome and metabolites in modulating ALS in mice

  E. Blacher, S. Bashiardes, H. Shapiro, D. Rothschild, U. Mor, M. Dori-Bachash, C. Kleimeyer, C. Moresi, Y. Harnik, M. Zur, M. Zabari, R. B. Z. Brik, D. Kviatcovsky, N. Zmora, Y. Cohen, N. Bar, I. Levi, N. Amar, T. Mehlman, A. Brandis, I. Biton, Y. Kuperman, M. Tsoory, L. Alfahel, A. Harmelin, M. Schwartz, A. Israelson, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, M. Gotkine, E. Segal, E. Elinav
  Nature - 2019
• Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

  Sjoerd van der Post, Karolina S. Jabbar, George M. H. Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjövall, Malin E V Johansson, Gunnar C. Hansson
  Gut - 2019
• Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties

  Elisabeth E. L. Nyström, Liisa Arike, Erik Ehrencrona, Gunnar C. Hansson, Malin E V Johansson
  Journal of Biological Chemistry - 2019
• Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

  Björn O. Schröder, George M. H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, Fredrik Bäckhed
  Cell Host & Microbe - 2018
• The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals

  Frida Svensson, T. G. Lang, Malin E V Johansson, Gunnar C. Hansson
  Scientific Reports - 2018
• Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity

  Elisabeth E. L. Nyström, George M. H. Birchenough, Sjoerd van der Post, Liisa Arike, A. D. Gruber, Gunnar C. Hansson, Malin E V Johansson
  Ebiomedicine - 2018
• Study of mucin turnover in the small intestine by in vivo labeling

  Hannah Schneider, Thaher Pelaseyed, Frida Svensson, Malin E V Johansson
  Scientific Reports - 2018
• Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice.

  K Bergstrom, J Fu, Malin E V Johansson, X Liu, N Gao, Q Wu, J Song, J M McDaniel, S McGee, W Chen, J Braun, Gunnar C. Hansson, L Xia
  Mucosal immunology - 2017
• Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection

  George M. H. Birchenough, F. Dalgakiran, L. A. Witcomb, Malin E V Johansson, A. J. McCarthy, Gunnar C. Hansson, P. W. Taylor
  Scientific Reports - 2017
• Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16.

  Joakim H. Bergström, George M. H. Birchenough, Gergely Katona, Björn O. Schröder, André Schütte, Anna Ermund, Malin E V Johansson, Gunnar C. Hansson
  Proceedings of the National Academy of Sciences of the United States of America - 2016
• Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and FCGBP

  Tiange Lang, Sofia Klasson, Erik Larsson, Malin E V Johansson, Gunnar C. Hansson, Tore Samuelsson
  Molecular Biology and Evolution - 2016
• A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

  George M. H. Birchenough, Elisabeth E. L. Nyström, Malin E V Johansson, Gunnar C. Hansson
  Science - 2016
• The Mucins

  Malin E V Johansson, Gunnar C. Hansson
  Encyclopedia of Immunobiology - 2016
• Immunological aspects of intestinal mucus and mucins

  Malin E V Johansson, Gunnar C. Hansson
  Nature Reviews Immunology - 2016
• The composition of the gut microbiota shapes the colon mucus barrier.

  Hedvig E Jakobsson, Ana María Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, Felix Sommer, Fredrik Bäckhed, Gunnar C. Hansson, Malin E V Johansson
  EMBO reports - 2015
• Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

  Malin E V Johansson, Hedvig E Jakobsson, Jessica Holmén Larsson, André Schütte, Anna Ermund, Ana María Rodríguez-Piñeiro, Liisa Arike, Catharina Wising, Frida Svensson, Fredrik Bäckhed, Gunnar C. Hansson
  Cell Host & Microbe - 2015
• Loss of NHE8 expression impairs intestinal mucosal integrity

  Aiping Wang, Jing Li, Yang Zhao, Malin E V Johansson, Hua Xu, Fayez K. Ghishan
  American Journal of Physiology - Gastrointestinal and Liver Physiology - 2015
• The colonic mucus protection depends on the microbiota

  Ana María Rodríguez-Piñeiro, Malin E V Johansson
  Gut microbes - 2015
• The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice

  N. A. Erickson, Elisabeth E. L. Nyström, L. Mundhenk, Liisa Arike, R. Glauben, M. M. Heimesaat, A. Fischer, S. Bereswill, George M. H. Birchenough, A. D. Gruber, Malin E V Johansson
  Plos One - 2015
• New developments in goblet cell mucus secretion and function

  George M. H. Birchenough, Malin E V Johansson, Jenny K Gustafsson, Joakim H. Bergström, Gunnar C. Hansson
  Mucosal Immunology - 2015
• Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis.

  Malin E V Johansson, Jenny K Gustafsson, Jessica Holmén Larsson, Karolina S. Jabbar, Lijun Xia, Hua Xu, Fayez K Ghishan, Frederic A Carvalho, Andrew T Gewirtz, Henrik Sjövall, Gunnar C. Hansson
  Gut - 2014
• The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

  Thaher Pelaseyed, Joakim H. Bergström, Jenny K Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana María Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E V Johansson, Gunnar C. Hansson
  Immunological Reviews - 2014
• Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture.

  Felix Sommer, Nina Adam, Malin E V Johansson, Lijun Xia, Gunnar C. Hansson, Fredrik Bäckhed
  PloS one - 2014
• Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis.

  Ulf Alexander Wenzel, Maria K Magnusson, Anna Rydström, Caroline Jonstrand, Julia Hengst, Malin E V Johansson, Anna Velcich, Lena Öhman, Hans Strid, Henrik Sjövall, Gunnar C. Hansson, Mary Jo Wick
  PloS one - 2014
• Is the intestinal goblet cell a major immune cell?

  Malin E V Johansson, Gunnar C. Hansson
  Cell host & microbe - 2014
• AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus.

  Joakim H. Bergström, Katarina A Berg, Ana María Rodríguez-Piñeiro, Bärbel Stecher, Malin E V Johansson, Gunnar C. Hansson
  PloS one - 2014
• Mucus Layers in Inflammatory Bowel Disease

  Malin E V Johansson
  Inflammatory Bowel Diseases - 2014
• Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

  André Schütte, Anna Ermund, C. Becker-Pauly, Malin E V Johansson, Ana María Rodríguez-Piñeiro, Fredrik Bäckhed, S.C. Müller, D. Lottaz, J.S. Bond, Gunnar C. Hansson
  Proceedings of the National Academy of Sciences of the United States of America - 2014
• Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer, and barrier impairment in mice.

  Fang Xiao, Qin Yu, Junhua Li, Malin E V Johansson, Anurag Kumar Singh, Weiliang Xia, Brigitte Riederer, Regina Engelhardt, Marshall Montrose, Manoocher Soleimani, De-An Tian, Gang Xu, Gunnar C. Hansson, Ursula Seidler
  Acta physiologica (Oxford, England) - 2014
• Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB).

  Sjoerd van der Post, Durai B Subramani, Malin Bäckström, Malin E V Johansson, Malene B Vester-Christensen, Ulla Mandel, Eric P Bennett, Henrik Clausen, Gunnar Dahlén, Aneta Sroka, Jan Potempa, Gunnar C. Hansson
  The Journal of biological chemistry - 2013

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