- Home
- About
- Find staff
- Davide Angeletti
Davide Angeletti
Senior Lecturer
Department of Microbiology andAbout Davide Angeletti
Seasonal influenza causes significant morbidity and mortality every year, with the possibility of global pandemic outbreaks. Current vaccines provide reasonable protection against circulating viruses but require yearly reformulation. Therefore, there is an urgent need to develop a vaccine that could provide long term immunity to the virus.
Our work aims at defining the basic immunological mechanisms of antibody and B cell responses as an essential step towards an effective universal vaccination.
Read more about our work here
-
Applying valency-based immuno-selection to generate broadly cross-reactive antibodies against influenza
hemagglutinins
Daniela Maria Hinke, Ane Marie Anderson, Kirankumar Katta, Marlene Fyrstenberg Laursen, Demo Yemane Tesfaye, Ina Charlotta Werninghaus, Davide Angeletti, Gunnveig Grodeland, Bjarne Bogen, Ranveig Braathen
NATURE COMMUNICATIONS - 2024 -
Pre-existing CD4 T cell help boosts antibody responses but has limited impact on germinal center, antigen-specific B cell frequencies after influenza
infection.
Danica F Besavilla, Laura Reusch, Josue Enriquez, Karin Schön, Davide Angeletti
Frontiers in immunology - 2023 -
Longitudinal single-cell analysis of SARS-CoV-2-reactive B cells uncovers persistence of early-formed, antigen specific
clones.
Lydia Scharf, Hannes Axelsson, Aikaterini Emmanouilidi , Nimitha Rose Mathew, Daniel J Sheward, Susannah Leach, Pauline Isakson, Ilya Smirnov, Emelie Marklund, Nicolae Miron, Lars-Magnus Andersson, Magnus Gisslén, Ben Murrell, Anna Lundgren, Mats Bemark, Davide Angeletti
JCI insight - 2023 -
Monoclonal antibodies lock down SARS-CoV-2
spike.
Hsiang-Chi Huang, Davide Angeletti
Trends in immunology - 2023 -
Plasmablasts in previously immunologically naive COVID-19 patients express markers indicating mucosal homing and secrete antibodies cross-reacting with SARS-CoV-2 variants and other
beta-coronaviruses
Anna Lundgren, Susannah Leach, Hannes Axelsson, Pauline Isakson, Kristina Nyström, Lydia Scharf, Bengt A. Andersson, Nicolae Miron, Emelie Marklund, Lars-Magnus Andersson, Magnus Gisslén, Davide Angeletti, Mats Bemark
Clinical and Experimental Immunology - 2023 -
Memory B cell diversity: from early generation to tissue residency and
reactivation.
Laura Reusch, Davide Angeletti
European journal of immunology - 2023 -
Tr1 cell-mediated protection against autoimmune disease by intranasal administration of a fusion protein targeting cDC1
cells.
Charlotta Hansson, Cristina Lebrero-Fernandez, Karin Schön, Davide Angeletti, Nils Y Lycke
Mucosal immunology - 2023 -
Profiling of innate and adaptive immune cells during influenza virus infection reveals sex bias in invariant natural killer T (iNKT)
cells
Piotr Humeniuk, Aidan Barrett, Hannes Axelsson, Carmen Corciulo, Christina Drevinge, Alicia M. del Carpio Pons, Davide Angeletti, Julia M. Scheffler, Ulrika Islander
Immunity, Inflammation and Disease - 2023 -
ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus
infection
Mohammad Arabpour, Cristina Lebrero-Fernandez, Karin Schön, Anneli Strömberg, Vanja Börjesson , K. Lahl, M. Ballegeer, X. Saelens, Davide Angeletti, W. Agace, Nils Y Lycke
Mucosal Immunology - 2022 -
Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal
centers.
Wenzhi Song, Olivia Q Antao, Emily Condiff, Gina M Sanchez, Irene Chernova, Krzysztof Zembrzuski, Holly Steach, Kira Rubtsova, Davide Angeletti, Alexander Lemenze, Brian J Laidlaw, Joe Craft, Jason S Weinstein
Immunity - 2022 -
Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus
infection
W. T. Yewdell, R. M. Smolkin, K. T. Belcheva, A. Mendoza, A. J. Michaels, M. Cols, Davide Angeletti, J. W. Yewdell, J. Chaudhuri
Cell Reports - 2021 -
CD4(+) follicular regulatory T cells optimize the influenza virus-specific B cell
response
Y. S. Lu, R. Jiang, A. W. Freyn, J. W. Wang, S. Strohmeier, K. Lederer, M. Locci, H. Y. Zhao, Davide Angeletti, K. C. O'Connor, S. H. Kleinstein, R. Nachbagauer, J. Craft
Journal of Experimental Medicine - 2021 -
Know your enemy or find your friend?-Induction of IgA at mucosal
surfaces.
Mats Bemark, Davide Angeletti
Immunological reviews - 2021 -
Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B
cells.
Nimitha Rose Mathew, Jayalal Jayanthan, Ilya Smirnov, Jonathan L Robinson, Hannes Axelsson, Sravya Sowdamini Nakka, Aikaterini Emmanouilidi , Paulo Czarnewski, William T Yewdell, Karin Schön, Cristina Lebrero-Fernandez, Valentina Bernasconi, William Rodin, Ali M Harandi, Nils Y Lycke, Nicholas Borcherding, Jonathan W Yewdell, Victor Greiff, Mats Bemark, Davide Angeletti
Cell reports - 2021 -
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast
response.
Vassilis Glaros, René Rauschmeier, Artem V Artemov, Annika Reinhardt, Sebastian Ols, Aikaterini Emmanouilidi , Charlotte Gustafsson, Yuanyuan You, Claudio Mirabello, Åsa K Björklund, Laurent Perez, Neil P King, Robert Månsson, Davide Angeletti, Karin Loré, Igor Adameyko, Meinrad Busslinger, Taras Kreslavsky
Immunity - 2021 -
Recombinant Influenza Vaccines: Saviors to Overcome
Immunodominance
Nimitha Rose Mathew, Davide Angeletti
Frontiers in Immunology - 2020 -
Influenza-infected newborn and adult monkeys exhibit a strong primary antibody response to hemagglutinin
stem
E. Clemens, Davide Angeletti, B. C. Holbrook, M. Kanekiyo, M. J. Jorgensen, B. S. Graham, J. Yewdell, M. A. Alexander-Miller
Jci Insight - 2020 -
A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin
Localization.
William T Yewdell, Youngjun Kim, Priyanka Chowdhury, Colleen M Lau, Ryan M Smolkin, Kalina T Belcheva, Keith C Fernandez, Montserrat Cols, Wei-Feng Yen, Bharat Vaidyanathan, Davide Angeletti, Adrian B McDermott, Jonathan W Yewdell, Joseph C Sun, Jayanta Chaudhuri
Immunity - 2020 -
Serum-IgG responses to SARS-CoV-2 after mild and severe COVID-19 infection and analysis of IgG
non-responders.
Emelie Marklund, Susannah Leach, Hannes Axelsson, Kristina Nyström, Helene Norder, Mats Bemark, Davide Angeletti, Anna Lundgren, Staffan Nilsson, Lars-Magnus Andersson, Aylin Yilmaz, Magnus Lindh, Jan-Åke Liljeqvist, Magnus Gisslén
PloS one - 2020 -
Outflanking immunodominance to target subdominant broadly neutralizing
epitopes
Davide Angeletti, I. Kosik, J. J. S. Santos, W. T. Yewdell, C. M. Boudreau, V. V. A. Mallajosyula, M. C. Mankowski, M. Chambers, M. Prabhakaran, H. D. Hickman, A. B. McDermott, G. Alter, J. Chaudhuri, J. W. Yewdell
Proceedings of the National Academy of Sciences of the United States of America - 2019 -
Understanding and Manipulating Viral Immunity: Antibody Immunodominance Enters Center
Stage.
Davide Angeletti, Jonathan W Yewdell
Trends in immunology - 2018 -
Antibody Immunodominance: The Key to Understanding Influenza Virus Antigenic
Drift.
Meghan O Altman, Davide Angeletti, Jonathan W Yewdell
Viral immunology - 2018 -
Is It Possible to Develop a "Universal" Influenza Virus Vaccine? Outflanking Antibody Immunodominance on the Road to Universal Influenza
Vaccination.
Davide Angeletti, Jonathan W Yewdell
Cold Spring Harbor perspectives in biology - 2018 -
Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease
Resistance.
Stephan P Rosshart, Brian G Vassallo, Davide Angeletti, Diane S Hutchinson, Andrew P Morgan, Kazuyo Takeda, Heather D Hickman, John A McCulloch, Jonathan H Badger, Nadim J Ajami, Giorgio Trinchieri, Fernando Pardo-Manuel de Villena, Jonathan W Yewdell, Barbara Rehermann
Cell - 2017 -
Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin
Avidity.
Davide Angeletti, Gregory M Frank, Jonathan W Yewdell
Methods in molecular biology (Clifton, N.J.) - 2017 -
Defining B cell immunodominance to
viruses.
Davide Angeletti, James S Gibbs, Matthew Angel, Ivan Kosik, Heather D Hickman, Gregory M Frank, Suman R Das, Adam K Wheatley, Madhu Prabhakaran, David J Leggat, Adrian B McDermott, Jonathan W Yewdell
Nature immunology - 2017 -
The aryl hydrocarbon receptor controls cell-fate decisions in B
cells.
Bharat Vaidyanathan, Ashutosh Chaudhry, William T Yewdell, Davide Angeletti, Wei-Feng Yen, Adam K Wheatley, Christopher A Bradfield, Adrian B McDermott, Jonathan W Yewdell, Alexander Y Rudensky, Jayanta Chaudhuri
The Journal of experimental medicine - 2017 -
Phagocytosis-inducing antibodies to Plasmodium falciparum upon immunization with a recombinant PfEMP1 NTS-DBL1α
domain.
Maria Del Pilar Quintana, Davide Angeletti, Kirsten Moll, Qijun Chen, Mats Wahlgren
Malaria journal - 2016 -
A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A
Virus.
Gregory M Frank, Davide Angeletti, William L Ince, James S Gibbs, Surender Khurana, Adam K Wheatley, Edward E Max, Adrian B McDermott, Hana Golding, James Stevens, Jack R Bennink, Jonathan W Yewdell
mBio - 2015 -
RIFINs are adhesins implicated in severe Plasmodium falciparum
malaria.
Suchi Goel, Mia Palmkvist, Kirsten Moll, Nicolas Joannin, Patricia Lara, Reetesh R Akhouri, Nasim Moradi, Karin Öjemalm, Mattias Westman, Davide Angeletti, Hanna Kjellin, Janne Lehtiö, Ola Blixt, Lars Ideström, Carl G Gahmberg, Jill R Storry, Annika K Hult, Martin L Olsson, Gunnar von Heijne, IngMarie Nilsson, Mats Wahlgren
Nature medicine - 2015