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Erik Smedler
Researcher
Department of Psychiatry and NeurochemistryAbout Erik Smedler
Background
I am a resident physician in psychiatry at Sahlgrenska University Hospital (SU) and research group leader at Gothenburg University (GU) with support from the Wallenberg Centre for Molecular and Translational Medicine and the Swedish Research Council. Prior to that, I did my MD-PhD at Karolinska Institutet and MSc in engineering physics at the Royal Institute of Technology in Stockholm. My thesis was focused on neural networks and calcium signaling. I did my postdoc in the group of Mikael Landén at GU 2017-2019 and medical internship at SU.
Resarch interests
My research is focused on bipolar disorder, with emphasis on neural development. My line of research is on how disturbances in the development of neural networks lead to manifest psychiatric illness, with focus on the calcium channel gene CACNA1C. At the moment, we are developing IPS cell-based models of bipolar patients in conjunction with clinical data from patients.
See my papers on Pubmed using: smedler e OR nilsson es
Read more on smedlerlab.org
Research group
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Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive
disorder
Jie Song, Lina Jonsson, Yi Lu, Sarah E. Bergen, Robert Karlsson, Erik Smedler, Katherine Gordon-Smith, Ian Jones, Lisa Jones, Nick Craddock, Patrick F. Sullivan, Paul Lichtenstein, Arianna Di Florio, Mikael Landén
MOLECULAR PSYCHIATRY - 2024 -
Effect of CYP2C19 polymorphisms on antidepressant prescription patterns and treatment emergent mania in bipolar
disorder.
Erik Joas, Lina Jonsson, Alexander Viktorin, Erik Smedler, Erik Pålsson, Guy M Goodwin, Mikael Landén
The pharmacogenomics journal - 2023 -
Association of premorbid intelligence with level of functioning and illness severity in bipolar
disorder.
Erik Smedler, Timea Sparding, Lina Jonsson, Elin Hörbeck, Mikael Landén
Journal of affective disorders - 2023 -
Cerebrospinal fluid proteomic study of two bipolar disorder
cohorts
Anniella Isgren, Andreas Göteson, Jessica Holmén Larsson, Aurimantas Pelanis, C. Sellgren, Erik Joas, Timea Sparding, Henrik Zetterberg, Erik Smedler, Joel Jakobsson, Mikael Landén
Molecular Psychiatry - 2022 -
Metabolomics analysis of cerebrospinal fluid suggests citric acid cycle aberrations in bipolar
disorder
Erik Smedler, Alireza Salehi, Aurimantas Pelanis, Ana Andreazza, Erik Pålsson, Timea Sparding, Mikael Landén
Neuroscience Applied - 2022 -
Disrupted Cacna1c gene expression perturbs spontaneous Ca2+ activity causing abnormal brain development and increased
anxiety.
Erik Smedler, Lauri Louhivuori, Roman A Romanov, Débora Masini, Ivar Dehnisch Ellström, Chungliang Wang, Martino Caramia, Zoe West, Songbai Zhang, Paola Rebellato, Seth Malmersjö, Irene Brusini, Shigeaki Kanatani, Gilberto Fisone, Tibor Harkany, Per Uhlén
Proceedings of the National Academy of Sciences of the United States of America - 2022 -
Cerebrospinal fluid and serum protein markers in autism: A co-twin
study.
Erik Smedler, Johanna Kleppe, Janina Neufeld, Karl Lundin, Sven Bölte, Mikael Landén
Journal of neurochemistry - 2021 -
Cerebrospinal fluid proteomics targeted for central nervous system processes in bipolar
disorder
Andreas Göteson, Anniella Isgren, Lina Jonsson, Timea Sparding, Erik Smedler, Aurimantas Pelanis, Henrik Zetterberg, Joel Jakobsson, Erik Pålsson, Jessica Holmén Larsson, Mikael Landén
Molecular Psychiatry - 2021 -
Association of CACNA1C polymorphisms with serum BDNF levels in bipolar
disorder.
Erik Smedler, Erik Pålsson, Kenji Hashimoto, Mikael Landén
The British journal of psychiatry : the journal of mental science - 2021 -
Reporting trigger factors for (hypo)manic episodes in bipolar disorder: association with personality and
prognosis.
Erik Smedler, Timea Sparding, Ali Hattab, Carl M Sellgren, Mikael Landén
Acta psychiatrica Scandinavica - 2020 -
CACNA1C polymorphism and brain cortical structure in bipolar
disorder
Erik Smedler, Christoph Abé, Erik Pålsson, Martin Ingvar, Mikael Landén
Journal of psychiatry & neuroscience : JPN - 2019 -
Genes, biomarkers, and clinical features associated with the course of bipolar
disorder.
Erik Smedler, Sarah E Bergen, Jie Song, Mikael Landén
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 2019 -
Mapping genes for calcium signaling and their associated human genetic
disorders.
Matthias Hörtenhuber, Enrique M Toledo, Erik Smedler, Ernest Arenas, Seth Malmersjö, Lauri Louhivuori, Per Uhlén
Bioinformatics (Oxford, England) - 2017 -
The 1p36 Tumor Suppressor KIF 1B beta Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and
Apoptosis
S. J. Li, S. M. Fell, O. Surova, Erik Smedler, K. Wallis, Z. X. Chen, U. Hellman, J. I. Johnsen, Tommy Martinsson, R. S. Kenchappa, P. Uhlen, P. Kogner, S. Schlisio
Developmental Cell - 2016 -
CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic
culture.
David Forsberg, Zachi Horn, Evangelia Tserga, Erik Smedler, Gilad Silberberg, Yuri Shvarev, Kai Kaila, Per Uhlén, Eric Herlenius
eLife - 2016 -
Calcium signaling in neocortical
development.
Per Uhlén, Nicolas Fritz, Erik Smedler, Seth Malmersjö, Shigeaki Kanatani
Developmental neurobiology - 2015 -
Network analysis of time-lapse microscopy
recordings.
Erik Smedler, Seth Malmersjö, Per Uhlén
Frontiers in neural circuits - 2014 -
Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in
vivo.
Min Wan, Oliver Soehnlein, Xiao Tang, Anne M van der Does, Erik Smedler, Per Uhlén, Lennart Lindbom, Birgitta Agerberth, Jesper Z Haeggström
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 2014 -
Frequency decoding of calcium
oscillations.
Erik Smedler, Per Uhlén
Biochimica et biophysica acta - 2014 -
Small-world networks of spontaneous Ca(2+)
activity.
Seth Malmersjö, Paola Rebellato, Erik Smedler, Per Uhlén
Communicative & integrative biology - 2013 -
Neural progenitors organize in small-world networks to promote cell
proliferation.
Seth Malmersjö, Paola Rebellato, Erik Smedler, Henrike Planert, Shigeaki Kanatani, Isabel Liste, Evanthia Nanou, Hampus Sunner, Shaimaa Abdelhady, Songbai Zhang, Michael Andäng, Abdeljabbar El Manira, Gilad Silberberg, Ernest Arenas, Per Uhlén
Proceedings of the National Academy of Sciences of the United States of America - 2013 -
Small molecule screening platform for assessment of cardiovascular toxicity on adult zebrafish
heart.
Satish Srinivas Kitambi, Erik Smedler, Petra Sekyrova, Cristian Ibarra, Gilbert Nyah Tekeoh, Michael Andäng, Patrik Ernfors, Per Uhlén
BMC physiology - 2012