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Sture Lindegren
Researcher
Department of Medical Radiation SciencesAbout Sture Lindegren
Associate Professor/Radiochemist/Institute of Clinical Sciences/Department of Medicinal Radiation Science/Sahlgrenska Academy at Gothenburg University
Working with radiopharmaceutical development for treatment of disseminated cancer.
Develop new strategies for optimal distribution of radiopharmaceuticals.
Has developed efficient methods isolation of Astatine-211 from irradiated bismuth targets and new methods for synthesizing astatine-211 radiopharmaceuticals. It also includes development of automatic procedures for synthesis of astatine-211 radiopharmaceuticals.
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A proposed production method for astatinated (At-211) Trastuzumab for use in a Phase I clinical
trial
Emma Aneheim, Tom Bäck, Holger Jensen, Stig Palm, Sture Lindegren
PLOS ONE - 2024 -
Modified poly-L-lysine for use as a clearing agent in pretargeted
radioimmunotherapy
Chiara Timperanza, Anna Gustafsson-Lutz, Tom Bäck, Damian J. Green, Sture Lindegren, Emma Aneheim
EJNMMI RADIOPHARMACY AND CHEMISTRY - 2024 -
Rapid Electrophilic 211At-Astatination of Trimethylgermyl
Arenes
Marius Mueller, Umberto Maria Battisti, Merlin Zabrocki, Ellinor Hansson, Holger Jensen, Emma Aneheim, Sture Lindegren, Matthias Manfred Herth
CHEMPLUSCHEM - 2024 -
In vitro and in vivo evaluation of a tetrazine-conjugated poly-L-lysine effector molecule labeled with
astatine-211
Chiara Timperanza, Holger Jensen, Ellinor Hansson, Tom Bäck, Sture Lindegren, Emma Aneheim
EJNMMI RADIOPHARMACY AND CHEMISTRY - 2024 -
Behaviour, use and safety aspects of astatine-211 solvated in chloroform after dry distillation
recovery
Emma Aneheim, Ellinor Hansson, Chiara Timperanza, Holger Jensen, Sture Lindegren
SCIENTIFIC REPORTS - 2024 -
A Novel Method for Real-Time Quantification of Radioligand Binding to Living Tumor Cells In
Vitro
Tom Bäck, Per Albertsson, Emma Aneheim, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren, Stig Palm
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS - 2024 -
Astatine-211 based radionuclide therapy: Current clinical trial
landscape
Per Albertsson, Tom Bäck, Karin Bergmark, Andreas Hallqvist, Mia Johansson, Emma Aneheim, Sture Lindegren, Chiara Timperanza, K. Smerud, Stig Palm
Frontiers in Medicine - 2023 -
Improved syntheses of P2X(7) ligands based on substituted benzyl amide of pyroglutamic acid motif labelled with iodine-123 or
iodine-125
A. Maresova, M. Jurasek, T. Zimmermann, P. Drasar, M. Petrik, P. Dzubak, Sture Lindegren, P. Cumming, R. Pichler, A. Popkov
Journal of Radioanalytical and Nuclear Chemistry - 2023 -
Pretargeted Alpha Therapy of Disseminated Cancer Combining Click Chemistry and
Astatine-211
Chiara Timperanza, H. Jensen, Tom Bäck, Sture Lindegren, Emma Aneheim
Pharmaceuticals - 2023 -
Estimating the risk for secondary cancer following targeted alpha therapy with astatine-211 intraperitoneal
radioimmunotherapy.
Erik Leidermark, Andreas Hallqvist, Lars Jacobsson, Per Karlsson, Erik Holmberg, Tom Bäck, Mia Johansson, Sture Lindegren, Stig Palm, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2022 -
Covalent core-radiolabeling of polymeric micelles with125I/211At for theranostic
radiotherapy
E. Sporer, C. B. M. Poulie, Tom Bäck, Sture Lindegren, H. Jensen, P. J. Kempen, A. Kjaer, M. M. Herth, A. I. Jensen
Nanotheranostics - 2022 -
Evaluation of therapeutic efficacy of 211At-labeled farletuzumab in an intraperitoneal mouse model of disseminated ovarian
cancer
Stig Palm, Tom Bäck, Emma Aneheim, Andreas Hallqvist, Ragnar Hultborn, Lars Jacobsson, H. Jensen, Sture Lindegren, Per Albertsson
Translational Oncology - 2021 -
Realizing Clinical Trials with Astatine-211: The Chemistry
Infrastructure
Sture Lindegren, Per Albertsson, Tom Bäck, H. Jensen, Stig Palm, Emma Aneheim
Cancer Biotherapy and Radiopharmaceuticals - 2020 -
Targeted alpha therapy with astatine-211-labeled anti-PSCA A11 minibody shows antitumor efficacy in prostate cancer xenografts and bone
microtumors
Tom Bäck, Karin Jennbacken, Malin Hagberg Thulin, Sture Lindegren, H. Jensen, T. Olafsen, P. J. Yazaki, Stig Palm, Per Albertsson, Jan-Erik Damber, A. M. Wu, Karin Welén
Ejnmmi Research - 2020 -
Labeling of Anti-HER2 Nanobodies with Astatine-211: Optimization and the Effect of Different Coupling Reagents on Their in Vivo
Behavior
Y. Dekempeneer, Tom Bäck, Emma Aneheim, H. Jensen, J. Puttemans, C. Xavier, M. Keyaerts, Stig Palm, Per Albertsson, T. Lahoutte, V. Caveliers, Sture Lindegren, M. D'Huyvetter
Molecular Pharmaceutics - 2019 -
Towards elucidating the radiochemistry of astatine - Behavior in
chloroform
Emma Aneheim, Stig Palm, H. Jensen, C. Ekberg, Per Albertsson, Sture Lindegren
Scientific Reports - 2019 -
Intraperitoneal alpha-Emitting Radioimmunotherapy with At-211 in Relapsed Ovarian Cancer: Long-Term Follow-up with Individual Absorbed Dose
Estimations
Andreas Hallqvist, Karin Bergmark, Tom Bäck, Håkan Andersson, Pernilla Dahm-Kähler, Mia Johansson, Sture Lindegren, H. Jensen, Lars Jacobsson, Ragnar Hultborn, Stig Palm, Per Albertsson
Journal of Nuclear Medicine - 2019 -
Astatine-211: The Chemistry
Infrastructure.
Sture Lindegren, Tom Bäck, Stig Palm, Holger Jensen, Per Albertsson, Emma Aneheim
Journal of Medical Imaging and Radiation Sciences - 2019 -
Intraperitoneal Alpha-emitting Radio Immunotherapy with Astatine-211 in Relapsed Ovarian Cancer; Long-term Follow-up with Individual Absorbed Dose
Estimations.
Andreas Hallqvist, Per Albertsson, Ragnar Hultborn, Stig Palm, Karin Bergmark, Tom Bäck, Håkan Andersson, Pernilla Dahm-Kähler, Mia Johansson, Sture Lindegren, Holger Jensen, Lars Jacobsson
Journal of Medical Imaging and Radiation Sciences - 2019 -
Estimation of Long-term Risks for Cancer Induction following Adjuvant Targeted Alpha Therapy with Curative
Intent.
Stig Palm, Andreas Hallqvist, Emma Aneheim, Tom Bäck, Mia Johansson, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren, Per Albertsson
Journal of Medical Imaging and Radiation Sciences - 2019 -
Quantified Cell Binding of Astatinated Immunoconjugates onOvarian Cancer Cell Spheroids by Alpha Camera
Imaging.
Tom Bäck, M Verhoeven, Emma Aneheim, Per Albertsson, Stig Palm, Sture Lindegren, Holger Jensen
Journal of Medical Imaging and Radiation Sciences - 2019 -
Multifunctional Clickable Reagents for Rapid Bioorthogonal Astatination and
Radio-Crosslinking
C. Denk, M. Wilkovitsch, Emma Aneheim, M. M. Herth, H. Jensen, Sture Lindegren, H. Mikula
ChemPlusChem - 2019 -
Model of Intraperitoneal Targeted α-Particle Therapy Shows That Posttherapy Cold-Antibody Boost Enhances Microtumor Radiation Dose and Treatable Tumor
Sizes.
Stig Palm, Tom Bäck, Sture Lindegren, Ragnar Hultborn, Lars Jacobsson, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2018 -
Cure of Human Ovarian Carcinoma Solid Xenografts by Fractionated alpha-Radioimmunotherapy with At-211-MX35-F(ab')(2): Influence of Absorbed Tumor Dose and Effect on Long-Term
Survival
Tom Bäck, N. Chouin, Sture Lindegren, Helena Kahu, H. Jensen, Per Albertsson, Stig Palm
Journal of Nuclear Medicine - 2017 -
Therapeutic efficacy of alpha-radioimmunotherapy with different activity levels of the Bi-213-labeled monoclonal antibody MX35 in an ovarian cancer
model
Anna Gustafsson-Lutz, Tom Bäck, Emma Aneheim, Ragnar Hultborn, Stig Palm, Lars Jacobsson, A. Morgenstern, F. Bruchertseifer, Per Albertsson, Sture Lindegren
EJNMMI Research - 2017 -
Biokinetic modeling and dosimetry for optimizing intraperitoneal radioimmunotherapy of ovarian cancer
microtumors.
Stig Palm, Tom Bäck, Börje Haraldsson, Lars Jacobsson, Sture Lindegren, Per Albertsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2016 -
17AAG-induced internalisation of HER2-specific Affibody
molecules
L. Göstring, Sture Lindegren, L. Gedda
Oncology Letters - 2016 -
Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide
Immunoconjugates
Emma Aneheim, Anna Gustafsson, Per Albertsson, Tom Bäck, Holger Jensen, Stig Palm, Sofia Svedhem, Sture Lindegren
Bioconjugate chemistry - 2016 -
Absorbed Doses and Risk Estimates of (211)At-MX35 F(ab')2 in Intraperitoneal Therapy of Ovarian Cancer
Patients.
Elin Cederkrantz, Håkan Andersson, Peter Bernhardt, Thomas Backhaus, Ragnar Hultborn, Lars Jacobsson, Holger Jensen, Sture Lindegren, Michael Ljungberg, Tobias Magnander, Stig Palm, Per Albertsson
International journal of radiation oncology, biology, physics - 2015 -
Binding Affinity, Specificity and Comparative Biodistribution of the Parental Murine Monoclonal Antibody MX35 (Anti-NaPi2b) and Its Humanized Version
Rebmab200.
Sture Lindegren, Luciana N S Andrade, Tom Bäck, Camila Maria L Machado, Bruno Brasil Horta, Carlos Buchpiguel, Ana Maria Moro, Oswaldo Keith Okamoto, Lars Jacobsson, Elin Cederkrantz, Kohshin Washiyama, Emma Aneheim, Stig Palm, Holger Jensen, Maria Carolina B Tuma, Roger Chammas, Ragnar Hultborn, Per Albertsson
PloS one - 2015 -
N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and
peptides
Emma Aneheim, Mark Foreman, H. Jensen, Sture Lindegren
Applied Radiation and Isotopes - 2015 -
Automated astatination of biomolecules--a stepping stone towards multicenter clinical
trials.
Emma Aneheim, Per Albertsson, Tom Bäck, Holger Jensen, Stig Palm, Sture Lindegren
Scientific reports - 2015 -
Shelf-Life of e-Lysyl-3-(Trimethylstannyl)Benzamide Immunoconjugates, Precursors for At-211 Labeling of
Antibodies
Emma Aneheim, Jenny Halleröd, Per Albertsson, H. Jensen, Stellan Holgersson, Sture Lindegren
Cancer Biotherapy and Radiopharmaceuticals - 2015 -
Astatine-211 labeling: a study towards automatic production of astatinated
antibodies
Emma Aneheim, Holger Jensen, Per Albertsson, Sture Lindegren
Journal of Radioanalytical and Nuclear Chemistry - 2015 -
Modelling the biokinetics of intra-peritoneally administered targeted alpha therapy on patients for improved
dosimetry.
Stig Palm, Tom Bäck, Sture Lindegren, Holger Jensen, Per Albertsson, Lars Jacobsson
Journal of Nuclear Medicine - 2014 -
Effective dose of intraperitoneal α-radioimmunotherapy with
211At.
Elin Cederkrantz, Tom Bäck, Lars Jacobsson, Holger Jensen, Sture Lindegren, Stig Palm, Per Albertsson
Journal of Nuclear Medicine - 2014 -
Image-based small-scale 3D-dosimetry in targeted alpha therapy using voxel dose-point kernels and alpha camera imaging of serial tissue
sections.
Tom Bäck, Nicolas Chouin, Sture Lindegren, Holger Jensen, Per Albertsson, Stig Palm
Journal of Nuclear Medicine - 2014 -
Polylysine-based Effector Molecules and Clearing Agents for Pretargeting Systems in Therapy and Imaging – Increasing Avidity and Specific Activity and Providing Many Ways to Optimize In Vivo
Distribution.
Anna Gustafsson-Lutz, Tom Bäck, Per Albertsson, Stig Palm, A Morgenstern, F Bruchertseifer, Sture Lindegren
European Journal of Nuclear Medicine and Molecular Imaging - 2014 -
Intra-tumoral dose distributions after experimental targeted alpha therapy by Alpha-Camera
imaging.
Nicolas Chouin, Stig Palm, Sture Lindegren, Holger Jensen, Per Albertsson, Tom Bäck
European Journal of Nuclear Medicine and Molecular Imaging - 2014 -
Alpha particle induced DNA damage and repair in normal cultured thyrocytes of different proliferation
status.
Madeleine Nordén Lyckesvärd, Ulla Delle, Helena Kahu, Sture Lindegren, Holger Jensen, Tom Bäck, John Swanpalmer, Kerstin Elmroth
Mutation research. Fundamental and molecular mechanisms of mutagenesis - 2014 -
Sequential Radioimmunotherapy with (177)Lu- and (211)At-Labeled Monoclonal Antibody BR96 in a Syngeneic Rat Colon Carcinoma
Model.
Sophie E Eriksson, Erika Elgström, Tom Bäck, Tomas Ohlsson, Holger Jensen, Rune Nilsson, Sture Lindegren, Jan Tennvall
Cancer biotherapy & radiopharmaceuticals - 2014 -
A radio-high-performance liquid chromatography dual-flow cell gamma-detection system for on-line radiochemical purity and labeling efficiency
determination.
Sture Lindegren, Holger Jensen, Lars Jacobsson
Journal of chromatography. A - 2014 -
Ex Vivo Activity Quantification in Micrometastases at the Cellular Scale Using the α-Camera
Technique.
Nicolas Chouin, Sture Lindegren, Sofia Frost, Holger Jensen, Per Albertsson, Ragnar Hultborn, Stig Palm, Lars Jacobsson, Tom Bäck
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2013 -
Comparison of (211)At-PRIT and (211)At-RIT of Ovarian Microtumors in a Nude Mouse
Model.
Sofia Frost, Tom Bäck, Nicolas Chouin, Ragnar Hultborn, Lars Jacobsson, Jörgen Elgqvist, Holger Jensen, Per Albertsson, Sture Lindegren
Cancer biotherapy & radiopharmaceuticals - 2013 -
Successful radioimmunotherapy of established syngeneic rat colon carcinoma with
211At-mAb.
Sophie E Eriksson, Tom Bäck, Erika Elgström, Holger Jensen, Rune Nilsson, Sture Lindegren, Jan Tennvall
EJNMMI research - 2013 -
Tumor Growth of Subcutaneous Xenografts after Repeated Alpha-Radioimmunotherapy with Astatine-211: What Absorbed Dose is Required to Treat Solid Tumors with Alpha-particle
Emitters?
Tom Bäck, Nicolas Chouin, Sture Lindegren, Holger Jensen, Stig Palm, Per Albertsson
European Journal of Nuclear Medicine and Molecular Imaging - 2012 -
Quantification of activity by alpha-camera imaging and small-scale dosimetry within ovarian carcinoma micrometastases treated with targeted alpha
therapy.
Nicolas Chouin, Sture Lindegren, Holger Jensen, Per Albertsson, Tom Bäck
Quarterly Journal of Nuclear Medicine and Molecular Imaging - 2012 -
Intraperitoneal Radionuclide Therapy:Clinical and Pre-Clinical
Considerations.
Jörgen Elgqvist, Sture Lindegren, Per Albertsson
Ovarian Cancer- Clinical and Therapeutuc Perspectives. - 2012 -
Comparison of therapeutic efficacy and biodistribution of (213)Bi- and (211)At-labeled monoclonal antibody MX35 in an ovarian cancer
model.
Anna Gustafsson, Tom Bäck, Jörgen Elgqvist, Lars Jacobsson, Ragnar Hultborn, Per Albertsson, Alfred Morgenstern, Frank Bruchertseifer, Holger Jensen, Sture Lindegren
Nuclear medicine and biology - 2012 -
Evaluation of Effects on the Peritoneum After Intraperitoneal α-Radioimmunotherapy with
(211)At.
Elin Cederkrantz, Eva Angenete, Tom Bäck, Peter Falk, Börje Haraldsson, Marie-Louise Ivarsson, Holger Jensen, Sture Lindegren, Ragnar Hultborn, Lars Jacobsson
Cancer biotherapy & radiopharmaceuticals - 2012 -
Statistical and dosimetric analysis of the penetration of antibody fragments F(ab')2 radiolabeled with 211At within subcutaneous
tumors.
Nicolas Chouin, Tom Bäck, M Bardies, Sofia Frost, Sture Lindegren, Stig Palm, O Press, Lars Jacobsson
Journal of Nuclear Medicine - 2011 -
In Vivo Distribution of Avidin-Conjugated MX35 and (211)At-Labeled, Biotinylated Poly-l-Lysine for Pretargeted Intraperitoneal
?-Radioimmunotherapy.
Sofia Frost, Tom Bäck, Nicolas Chouin, Holger Jensen, Ragnar Hultborn, Lars Jacobsson, Sture Lindegren
Cancer biotherapy & radiopharmaceuticals - 2011 -
Pretargeted Radioimmunotherapy with α-Particle Emitting
Radionuclides.
Sture Lindegren, Sofia Frost
Current radiopharmaceuticals - 2011 -
RBE of <sub> α</sub>-particles from <sup>211</sup>At for complex DNA damage and cell survival in relation to cell cycle
positio.
Kristina Claesson, Karin Magnander, Helena Kahu, Sture Lindegren, Ragnar Hultborn, Kerstin Elmroth
International journal of radiation biology - 2011 -
Ovarian cancer: background and clinical
perspectives
Jörgen Elgqvist, Ragnar Hultborn, Sture Lindegren, Stig Palm
Targeted Radionuclide Therapy - 2010 -
Intraperitoneal Alpha-Radioimmunotherapy of Advanced Ovarian Cancer in Nude Mice using Different High Specific
Activities
Jörgen Elgqvist, Daniel Ahlberg, Håkan Andersson, Holger Jensen, Bengt R Johansson, Helena Kahu, Marita Olsson, Sture Lindegren
World Journal of Oncology - 2010 -
Repeated Intraperitoneal alpha-Radioimmunotherapy of Ovarian Cancer in
Mice.
Jörgen Elgqvist, Håkan Andersson, Holger Jensen, Helena Kahu, Sture Lindegren, Elisabet Warnhammar Finnborg, Ragnar Hultborn
Journal of oncology - 2010 -
In vitro evaluation of avidin antibody pretargeting using 211At-labeled and biotinylated poly-L-lysine as effector
molecule.
Sofia Frost, Holger Jensen, Sture Lindegren
Cancer - 2010 -
Intraperitoneal alpha-radioimmunotherapy in mice using different specific
activities.
Jörgen Elgqvist, Håkan Andersson, Elin Haglund, Holger Jensen, Helena Kahu, Sture Lindegren, Elisabet Warnhammar Finnborg, Ragnar Hultborn
Cancer biotherapy & radiopharmaceuticals - 2009 -
Intraperitoneal alpha-particle radioimmunotherapy of ovarian cancer patients: pharmacokinetics and dosimetry of (211)At-MX35 F(ab')2--a phase I
study.
Håkan Andersson, Elin Cederkrantz, Tom Bäck, Chaitanya Divgi, Jörgen Elgqvist, Jakob Himmelman, György Horvath, Lars Jacobsson, Holger Jensen, Sture Lindegren, Stig Palm, Ragnar Hultborn
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2009 -
Glomerular filtration rate after alpha-radioimmunotherapy with 211At-MX35-F(ab')2: a long-term study of renal function in nude
mice.
Tom Bäck, Börje Haraldsson, Ragnar Hultborn, Holger Jensen, Martin E Johansson, Sture Lindegren, Lars Jacobsson
Cancer biotherapy & radiopharmaceuticals - 2009 -
Intraperitoneal alpha-radioimmunotherapy of ovarian cancer – pharmacokinetics and dosimetry of 211At-MX35 F(ab’)2 in a phase I
study.
E Haglund, Håkan Andersson, Tom Bäck, C Divgi, Jörgen Elgqvist, Sofia Frost, Jakob Himmelman, György Horvath, Ragnar Hultborn, Holger Jensen, Sture Lindegren, Stig Palm, Lars Jacobsson
Cancer Biotherapy and Radiopharmaceuticals - 2008 -
Intraperitoneal alpha-radioimmunotherapy of ovarian cancer – pharmacokinetics and dosimetry of 211At-MX35 F(ab’)2 in a phase I
study.
E Haglund, Håkan Andersson, Tom Bäck, C Divgi, Jörgen Elgqvist, Sofia Frost, Jakob Himmelman, György Horvath, Ragnar Hultborn, Holger Jensen, Sture Lindegren, Stig Palm, Lars Jacobsson
Radiotherapy and Oncology - 2008 -
Direct procedure for the production of 211At-labeled antibodies with an epsilon-lysyl-3-(trimethylstannyl)benzamide
immunoconjugate.
Sture Lindegren, Sofia Frost, Tom Bäck, Elin Haglund, Jörgen Elgqvist, Holger Jensen
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2008 -
Therapeutic efficacy of astatine-211-labeled trastuzumab on radioresistant SKOV-3 tumors in nude
mice.
Stig Palm, Tom Bäck, Ingela Claesson, Anna Danielsson, Jörgen Elgqvist, Sofia Frost, Ragnar Hultborn, Holger Jensen, Sture Lindegren, Lars Jacobsson
International journal of radiation oncology, biology, physics - 2007 -
Biodistribution of free 225Ac in nude
mice.
Stig Palm, Tom Bäck, Jörgen Elgqvist, Ragnar Hultborn, Helena Kahu, Sture Lindegren, Elisabet Warnhammar, Lars Jacobsson
Cancer Biotherapy and Radiopharmaceuticals - 2006 -
Pharmacokinetics and dosimetry of 211At-MX35 F(ab')2 in therapy of ovarian cancer - preliminary results from an ongoing phase I
study.
Ragnar Hultborn, Håkan Andersson, Tom Bäck, C Divgi, Jörgen Elgqvist, Jakob Himmelman, György Horvath, Holger Jensen, Sture Lindegren, Stig Palm, Lars Jacobsson
Cancer Biotherapy and Radiopharmaceuticals - 2006 -
Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35
F(ab')2.
Jörgen Elgqvist, Håkan Andersson, Peter Bernhardt, Tom Bäck, Ingela Claesson, Ragnar Hultborn, Holger Jensen, Bengt R Johansson, Sture Lindegren, Marita Olsson, Stig Palm, Elisabet Warnhammar Finnborg, Lars Jacobsson
International journal of radiation oncology, biology, physics - 2006 -
Alpha-radioimmunotherapy of intraperitoneally growing OVCAR-3 tumors of variable dimensions: Outcome related to measured tumor size and mean absorbed
dose.
Jörgen Elgqvist, Håkan Andersson, Tom Bäck, Ingela Claesson, Ragnar Hultborn, Holger Jensen, Bengt R Johansson, Sture Lindegren, Marita Olsson, Stig Palm, Elisabet Warnhammar Finnborg, Lars Jacobsson
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2006 -
Fractionated radioimmunotherapy of intraperitoneally growing ovarian cancer in nude mice with 211At-MX35 F(ab')2: therapeutic efficacy and
myelotoxicity
Jörgen Elgqvist, Håkan Andersson, Tom Bäck, Ingela Claesson, Ragnar Hultborn, H. Jensen, Sture Lindegren, Marita Olsson, Stig Palm, Elisabet Warnhammar Finnborg, Lars Jacobsson
Nucl Med Biol - 2006 -
Alpha-particle emitter [211At] mediated anticancer efficacy of Trastuzumab: Single-dose and fractionated 211At-Herceptin therapy in a nude mouse ovarian carcinoma
model.
Stig Palm, Tom Bäck, Ingela Claesson, Jörgen Elgqvist, Ragnar Hultborn, Börje Karlsson, Sture Lindegren, Lars Jacobsson
Journal of Nuclear Medicine - 2005 -
Therapeutic efficacy and tumor dose estimations in radioimmunotherapy of intraperitoneally growing OVCAR-3 cells in nude mice with (211)At-labeled monoclonal antibody
MX35
Jörgen Elgqvist, Håkan Andersson, Tom Bäck, Ragnar Hultborn, H. Jensen, Börje Karlsson, Sture Lindegren, Stig Palm, Elisabet Warnhammar Finnborg, Lars Jacobsson
J Nucl Med - 2005 -
211At radioimmunotherapy of subcutaneous human ovarian cancer xenografts: evaluation of relative biologic effectiveness of an alpha-emitter in
vivo
Tom Bäck, Håkan Andersson, C. R. Divgi, Ragnar Hultborn, H. Jensen, Sture Lindegren, Stig Palm, Lars Jacobsson
J Nucl Med - 2005 -
Myelotoxicity and RBE of 211At-conjugated monoclonal antibodies compared with 99mTc-conjugated monoclonal antibodies and 60Co irradiation in nude
mice
Jörgen Elgqvist, Peter Bernhardt, Ragnar Hultborn, H. Jensen, Börje Karlsson, Sture Lindegren, Elisabet Warnhammar Finnborg, Lars Jacobsson
J Nucl Med - 2005 -
Antitumor effect of At-211-radioimmunotherapy on subcutaneous human ovarian cancer xenografts: Evaluation of RBE of an alpha emitter in
vivo.
Tom Bäck, Stig Palm, Sture Lindegren, Börje Karlsson, Ragnar Hultborn, Lars Jacobsson
Cancer Biotherapy and Radiopharmaceuticals - 2004 -
Single-cell irradiation from [211At] astatine-labeled C215 monoclonal antibody: improved estimates of radiosensitivity from measurements on cellular uptake and
retention
Stig Palm, Tom Bäck, Ingela Claesson, Ulla Delle, Ragnar Hultborn, Sture Lindegren, Lars Jacobsson
Anticancer Res - 2003 -
Astatine-211-labeled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumor
model
Håkan Andersson, Jörgen Elgqvist, György Horvath, Ragnar Hultborn, Lars Jacobsson, H. Jensen, Börje Karlsson, Sture Lindegren, Stig Palm
Clin Cancer Res - 2003 -
(211)At-labeled and biotinylated effector molecules for pretargeted radioimmunotherapy using poly-L- and poly-D-Lysine as
multicarriers
Sture Lindegren, Börje Karlsson, Lars Jacobsson, Håkan Andersson, Ragnar Hultborn, G. Skarnemark
Clin Cancer Res - 2003 -
At-211 labelled antibodies for treatment of disseminated ovarian cancer: an overview of results in an ovarian tumour
model.
Ragnar Hultborn, Håkan Andersson, Tom Bäck, Ingela Claesson, Ulla Delle, Jörgen Elgqvist, György Horvath, Lars Jacobsson, Holger Jensen, Sture Lindegren, Stig Palm, Elisabet Warnhammar Finnborg
Cancer Biotherapy and Radiopharmaceuticals - 2002 -
Comparison of hematological toxicity of the alpha emitter 211At and the electron emitter 99mTc in nude
mice.
Jörgen Elgqvist, Peter Bernhardt, Ragnar Hultborn, Börje Karlsson, Sture Lindegren, Stig Palm, Lars Jacobsson
Cancer Biotherapy and Radiopharmaceuticals - 2002 -
Astatine-211 and Iodine Conjugates: Radiohalogenation and Preclinical Pharmacokinetics for Targeted and Pretargeted
Radioimmunotherapy
Sture Lindegren
2002 -
Synthesis and biodistribution of 211At-labeled, biotinylated, and charge-modified poly-L-lysine: evaluation for use as an effector molecule in pretargeted intraperitoneal tumor
therapy.
Sture Lindegren, Håkan Andersson, Lars Jacobsson, Tom Bäck, Gunnar Skarnemark, Börje Karlsson
Bioconjugate chemistry - 2002 -
Exploring the anticancer potential of the alpha-particle emitter
astatine-211.
Stig Palm, Håkan Andersson, Tom Bäck, Ingela Claesson, Ulla Delle, György Horvath, Ragnar Hultborn, Lars Jacobsson, Börje Karlsson, Sture Lindegren
Anticancer Research - 2001 -
Comparison of the therapeutic efficacy of 211At- and 131I-labelled monoclonal antibody MOv18 in nude mice with intraperitoneal growth of human ovarian
cancer.
Håkan Andersson, Stig Palm, Sture Lindegren, Tom Bäck, Lars Jacobsson, Gunilla Leser, György Horvath
Anticancer research - 2001 -
In vitro effects and microdosimetry of 211At for tumour
therapy.
Stig Palm, Håkan Andersson, Tom Bäck, Ingela Claesson, Ulla Delle, Ragnar Hultborn, Lars Jacobsson, Istvan Köpf, Sture Lindegren
International Journal of Radiation Oncology, Biology, Physics - 2000 -
In vitro effects of free 211At,211At-albumin and 211At-monoclonal antibody compared to external photon irradiation on two human cancer cell
lines
Stig Palm, Håkan Andersson, Tom Bäck, Ingela Claesson, Ulla Delle, Ragnar Hultborn, Lars Jacobsson, Istvan Köpf, Sture Lindegren
Anticancer Res - 2000 -
Cell growth kinetics of the human cell line Colo-205 irradiated with photons and astatine-211
alpha-particles
Stig Palm, Håkan Andersson, Tom Bäck, Ingela Claesson, Ulla Delle, Ragnar Hultborn, Lars Jacobsson, Istvan Köpf, Sture Lindegren
Anticancer Res - 2000 -
Effects of the alpha-particle emitter At-211 and low-dose-rate gamma-radiation on the human cell line Colo-205 as studied with a growth
assay
Stig Palm, Tom Bäck, Ingela Claesson, Ulla Delle, Ragnar Hultborn, Lars Jacobsson, Istvan Köpf, Sture Lindegren
Anticancer Res - 1998