Giovanni Solinas

Professor

Department of Molecular and Clinical Medicine

Mail

giovanni.solinas@gu.se

Visiting address

Bruna stråket 16 Wallenberglaboratoriet, Sahlgrenska Universitetssjukhuset

41345 Göteborg

Postal address

Wallenberglaboratoriet, Sahlgrenska Universitetssjukhuset

41345 Göteborg

Professor

Department of Molecular and Clinical Medicine

Mail

giovanni.solinas@gu.se

Visiting address

Blå stråket 16, Wallenberglaboratoriet, Sahlgrenska Universitetssjukhuset

41345 Göteborg

Postal address

Wallenberglaboratoriet, Sahlgrenska Universitetssjukhuset

41345 Göteborg

About Giovanni Solinas

Professor, Principal Investigator
Giovanni Solinas moved to the Wallenberg Laboratory from the University of Fribourg, Switzerland, in 2014. He is currently professor of molecular medicine in the Department of Molecular and Clinical Medicine. His team investigates the molecular mechanisms underlying the metabolic stress associated with obesity and the role of these mechanisms in the pathogenesis of obesity and obesity-induced type 2 diabetes and tumor promotion.

Honors

2013 European Foundation for the Study of Diabetes (EFSD). Diabetes and Cancer Research Programme Award.
2012 Prix de la Fondation Endocrinologie Geneve.
2010 European Foundation for the Study of Diabetes (EFSD). Diabetes and Cancer Research Programme Award.
2009 European Foundation for the Study of Diabetes, EFSD/Lilly Research Fellowship Award.
2008 Novartis Research Foundation Research Grant.
2007 Roche Research Foundation Startup Fellowship.
2004 American Diabetes Association (ADA) Mentor Based Post-Doctoral Fellowship.
2003 Swiss National Science Foundation (SNSF) Post-Doctoral Fellowship for Prospective Investigators.
1996 University of Milan “Summa cum Laude”.

Background

1996 MSc University of Milan (Italy).
2002 PhD in Biochemistry at the University of Fribourg (Switzerland).
2002-2003 Post-doctoral research associate, Division of Physiology, University of Fribourg.
2003-2007 Post-doctoral fellow, Department of Pharmacology, University of California, San Diego (USA).
2007-2014 Assistant Professor in Molecular Physiology, Department of Medicine, University of Fribourg (Switzerland).
2014 Professor of Molecular Medicine, The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg (Sweden).

Group members

Barbara Becattini, PhD, Senior Scientist
Arianna Mazzoli, PhD Student
Angela Molinaro, PhD Student

Key Publications

Molinaro Angela; Becattini B.; Mazzoli A.; Bleve A.; Radici L.; Maxvall I.; Rotter Sopasakis V.; Molinaro Antonio; Bäckhed F.; Solinas G.* Insulin-Driven PI3K-AKT Signaling in the Hepatocyte is Mediated by Redundant PI3Ka and PI3Kb Activities and is Promoted by RAS. Cell Metabolism 2019 June 4;29(6):1400-1409.
Bousquenaud M.; Fico F.; Solinas G; Rüegg C.; and Santamaria-Martínez A. Obesity promotes the expansion of metastasis-initiating cells. 2018 Breast Cancer Research 2018 Sep 4;20(1):104.
Giovanni Solinas and Barbara Becattini The role of PI3Kγ in metabolism and macrophage activation Oncotarget, 2017, Vol. 8, (No. 63), pp: 106145-106146 Breasson L, Sardi C, Becattini B, Zani F, Solinas G. PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis. FASEB J. 2017 Sep 13. pii: fj.201700372RR. doi:
Breasson L, Becattini B, Sardi C, Molinaro A, Zani F, Marone R, Botindari F, Bousquenaud M, Ruegg C, Wymann MP, Solinas G. PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity. Sci Signal. 2017 Jul 18;10(488). pii: eaaf2969. doi: 10.1126/scisignal.aaf2969.
Solinas G, Becattini B. JNK at the crossroad of obesity, insulin resistance, and cell stress response. Mol Metab. 2016 Dec 8;6(2):174-184. doi: 10.1016/j.molmet.2016.12.001. eCollection 2017 Feb. Review.
Becattini B, Zani F, Breasson L, Sardi C, D'Agostino VG, Choo MK, Provenzani A, Park JM, Solinas G. JNK1 ablation in mice confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidative damage. FASEB J. 2016 Sep;30(9):3124-32. doi: 10.1096/fj.201600393R. Epub 2016 May 26.
Solinas G, Borén J, Dulloo AG. De novo lipogenesis in metabolic homeostasis: More friend than foe? Mol Metab. 2015 Mar 20;4(5):367-77. doi: 10.1016/j.molmet.2015.03.004. eCollection 2015 May. Review.
Zani F, Breasson L, Becattini B, Vukolic A, Montani JP, Albrecht U, Provenzani A, Ripperger JA, Solinas G. PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression. Mol Metab. 2013 Jul 1;2(3):292-305. doi: 10.1016/j.molmet.2013.06.006. eCollection 2013. Wymann M, Solinas G. Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors. Ann NY Acad Sci 1280:44-47 (2013)
Zani F, Breasson L, Becattini B, Montani JP, Provenzani A, Albrecht U, Ripperger JA, Solinas G. PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression. Mol Metab 2:292-395 (2013)
Marcelino H, Veyrat-Durebex C, Summermatter S, Sarafian D, Miles-Chan J, Arsenijevic D, Zani F, Montani JP, Seydoux J, Solinas G, Rohner-Jeanrenaud F, Dulloo AG. A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth: a Randle cycle favoring fat storage. Diabetes 62:362-372 (2013)
Solinas G. Molecular pathways linking metabolic inflammation and thermogenesis. Obes Rev 13 (Suppl 2):69-82 (2012)
Becattini B, Marone R, Zani F, Arsenijevic D, Seydoux J, Montani JP, Dulloo AG, Thorens B, Preintner F, Wymann MP, Solinas G. PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Proc Natl Acad Sci USA 108:E854-E863 (2011)
Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147:173-184 (2011)
Solinas G, Karin M. JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction. FASEB J 24: 2596-2611 (2010)
Summermatter S, Marcelino H, Arsenijevic D, Buchala A, Aprikian O, Assimacopoulos-Jeannet F, Seydoux J, Montani JP, Solinas G, Dulloo AG. Adipose tissue plasticity during catch-up fat driven by thrifty metabolism: relevance for muscle-adipose glucose redistribution during catch-up growth. Diabetes 58:2228-2237 (2009)