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- Gunnar Brinkmalm
Gunnar Brinkmalm
Researcher
Institute of Neuroscience and PhysiologyAvd-/Sektionschef, bitr, inst
Department of Psychiatry and Neurochemistry-
Alzheimer's Disease Biomarker Analysis Using Targeted Mass
Spectrometry.
Johan Gobom, Ann Brinkmalm-Westman, Gunnar Brinkmalm, Kaj Blennow, Henrik Zetterberg
Molecular & cellular proteomics : MCP - 2024 -
Tau protein profiling in tauopathies: a human brain
study
Juan Lantero Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko-Burmann, Bruno Becker, Ann Brinkmalm, Björn Marcus Burmann, Michael Perkinton, Nicholas J. Ashton, Nick C. Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmalm
MOLECULAR NEURODEGENERATION - 2024 -
Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer's disease with APPdup and Down
syndrome
Amal Kasri, Elena Camporesi, Eleni Gkanatsiou, Susana Boluda, Gunnar Brinkmalm, Lev Stimmer, Junyue Ge, Jörg Hanrieder, Nicolas Villain, Charles Duyckaerts, Yannick Vermeiren, Sarah E. Pape, Gael Nicolas, Annie Laquerriere, Peter Paul De Deyn, David Wallon, Kaj Blennow, Andre Strydom, Henrik Zetterberg, Marie-Claude Potier
ACTA NEUROPATHOLOGICA - 2024 -
Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease
neuropathology.
Przemyslaw R. Kac, Fernando Gonzalez-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas Karikari
Nature communications - 2024 -
Profiling amyloid-β peptides as biomarkers for cerebral amyloid
angiopathy
Emma van den Berg, Iris Kersten, Gunnar Brinkmalm, Kjell Johansson, Anna M. de Kort, Catharina J. M. Klijn, Floris H. B. M. Schreuder, Johan Gobom, Erik Stoops, Erik Portelius, Eleni Gkanatsiou, Henrik Zetterberg, Kaj Blennow, Hinke B. Kuiperij, Marcel M. Verbeek
JOURNAL OF NEUROCHEMISTRY - 2024 -
Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy
study.
Laia Montoliu-Gaya, Michael L Alosco, Eukyung Yhang, Yorghos Tripodis, Daniel Sconzo, Madeline Ally, Lana Grötschel, Nicholas J. Ashton, Juan Lantero Rodriguez, Mathias Sauer, Bárbara Fernandes Gomes, Johanna Nilsson, Gunnar Brinkmalm, Michael A Sugarman, Hugo J Aparicio, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkin, Katherine W Turk, Andrew E Budson, Rhoda Au, Lindsay Farrer, Gyungah R Jun, Neil W Kowall, Robert A Stern, Lee E Goldstein, Wei Qiao Qiu, Jesse Mez, Bertrand Russell Huber, Victor E Alvarez, Ann C McKee, Henrik Zetterberg, Johan Gobom, Thor D Stein, Kaj Blennow
Acta neuropathologica - 2024 -
CSF p-tau205: a biomarker of tau pathology in Alzheimer's
disease.
Juan Lantero Rodriguez, Laia Montoliu-Gaya, Andréa Lessa Benedet, Agathe Vrillon, Julien Dumurgier, Emmanuel Cognat, Wagner Scheeren Brum, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Bruno Becker, Gunnar Brinkmalm, Anniina Snellman, Hanna Huber, Hlin Kvartsberg, Nicholas J. Ashton, Henrik Zetterberg, Claire Paquet, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2024 -
SCRN1: A cerebrospinal fluid biomarker correlating with tau in Alzheimer's
disease
Sophia Weiner, Mathias Sauer, Gunnar Brinkmalm, Julius Constantinescu, Radu Constantinescu, Bárbara Fernandes Gomes, Bruno Becker, Bengt Nellgård, Keti Dalla, Douglas Galasko, Henrik Zetterberg, Kaj Blennow, Johan Gobom
Alzheimer's and Dementia - 2023 -
Cerebrospinal Fluid Panel of Synaptic Proteins in Cerebral Amyloid Angiopathy and Alzheimer's
Disease
E. van den Berg, Johanna Nilsson, I. Kersten, Gunnar Brinkmalm, A. M. de Kort, C. J. M. Klijn, Fhbm Schreuder, L. Jakel, Johan Gobom, E. Portelius, Henrik Zetterberg, Ann Brinkmalm, Kaj Blennow, H. B. Kuiperij, M. M. Verbeek
Journal of Alzheimers Disease - 2023 -
Decreased Cerebrospinal Fluid Amyloid beta 38, 40, 42, and 43 Levels in Sporadic and Hereditary Cerebral Amyloid
Angiopathy
A. M. De Kort, H. B. Kuiperij, T. M. Marques, L. Jakel, E. van den Berg, I. Kersten, H. E. P. van Berckel-Smit, M. Duering, E. Stoops, W. F. Abdo, I. Rasing, S. Voigt, E. A. Koemans, K. Kaushik, A. D. Warren, S. M. Greenberg, Gunnar Brinkmalm, G. M. Terwindt, M. J. H. Wermer, Fhbm Schreuder, C. J. M. Klijn, M. M. Verbeek
Annals of neurology - 2023 -
Plasma p-tau212: antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease
neuropathology.
Przemyslaw R. Kac, Fernándo González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas Karikari
medRxiv : the preprint server for health sciences - 2023 -
Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau
pathologies
Laia Montoliu-Gaya, Andréa Lessa Benedet, C. Tissot, A. Vrillon, Nicholas J. Ashton, Wagner Scheeren Brum, Juan Lantero Rodriguez, J. Stevenson, Johanna Nilsson, Mathias Sauer, N. Rahmouni, Gunnar Brinkmalm, F. Z. Lussier, T. A. Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, C. Paquet, Johan Gobom, P. Rosa-Neto, Kaj Blennow
Nature Aging - 2023 -
Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic
activity
S. Schilling, Ajay Pradhan, A. Heesch, A. Helbig, Kaj Blennow, C. Koch, L. Bertgen, E. H. Koo, Gunnar Brinkmalm, Henrik Zetterberg, S. Kins, S. Eggert
Acta Neuropathologica Communications - 2023 -
Antibody-free measurement of cerebrospinal fluid tau phosphorylation across the Alzheimer's disease
continuum.
Johan Gobom, Andréa Lessa Benedet, Niklas Mattsson-Carlgren, Laia Montoliu-Gaya, Nina Schultz, Nicholas J. Ashton, Shorena Janelidze, Stijn Servaes, Mathias Sauer, Tharick A Pascoal, Thomas Karikari, Juan Lantero Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
Molecular neurodegeneration - 2022 -
Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy
21.
Paige Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou, Gloria Lau, Sue Noy, Karen Cleverley, Takashi Saito, Takaomi C Saido, Eugene Yu, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Henrik Zetterberg, Victor Tybulewicz, Elizabeth M C Fisher, Frances K Wiseman
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2022 -
Chemical traits of cerebral amyloid angiopathy in familial British-, Danish-, and non-Alzheimer 's
dementias
Wojciech Michno, Srinivas Koutarapu, Rafael Camacho, C. Toomey, Katie Stringer, Karolina Minta, Junyue Ge, Durga Jha, Julia Fernandez-Rodriguez, Gunnar Brinkmalm, Henrik Zetterberg, Kaj Blennow, N. S. Ryan, T. Lashley, Jörg Hanrieder
Journal of Neurochemistry - 2022 -
Specific Mutations in the Cholesterol-Binding Site of APP Alter Its Processing and Favor the Production of Shorter, Less Toxic A beta
Peptides
L. Hanbouch, B. Schaack, A. Kasri, G. Fontaine, Eleni Gkanatsiou, Gunnar Brinkmalm, Elena Camporesi, Erik Portelius, Kaj Blennow, G. Mourier, N. Gilles, M. J. Millan, C. Marquer, Henrik Zetterberg, L. Boussicault, M. C. Potier
Molecular Neurobiology - 2022 -
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical
utility
Thomas Karikari, Nicholas J. Ashton, Gunnar Brinkmalm, Wagner Scheeren Brum, Andréa Lessa Benedet, Laia Montoliu-Gaya, Juan Lantero Rodriguez, T. A. Pascoal, M. Suarez-Calvet, P. Rosa-Neto, Kaj Blennow, Henrik Zetterberg
Nature Reviews Neurology - 2022 -
Cerebrospinal fluid amyloid precursor protein as a potential biomarker of fatigue in multiple sclerosis: A pilot
study
Kalle Johansson, Pontus Wasling, Lenka Novakova, S. Sjodin, Ann Brinkmalm, Gunnar Brinkmalm, Kaj Blennow, Henrik Zetterberg, Markus Axelsson
Multiple Sclerosis and Related Disorders - 2022 -
Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer's disease
patients
M. P. Lennol, I. Sanchez-Dominguez, I. Cuchillo-Ibanez, Elena Camporesi, Gunnar Brinkmalm, D. Alcolea, J. Fortea, A. Lleo, G. Soria, F. Aguado, Henrik Zetterberg, Kaj Blennow, J. Saez-Valero
Alzheimers Research & Therapy - 2022 -
Quantification of the trans-synaptic partners neurexin-neuroligin in CSF of neurodegenerative diseases by parallel reaction monitoring mass
spectrometry
Elena Camporesi, Johanna Nilsson, A. Vrillon, E. Cognat, C. Hourregue, Henrik Zetterberg, Kaj Blennow, Bruno Becker, Ann Brinkmalm, C. Paquet, Gunnar Brinkmalm
Ebiomedicine - 2022 -
γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane
processing.
Tobias A Weber, Johan Lundkvist, Johanna Wanngren, Hlin Kvartsberg, ShaoBo Jin, Pia Larssen, Dan Wu, Daniel V Oliveira, Karolina Minta, Gunnar Brinkmalm, Henrik Zetterberg, Kaj Blennow, Gunnar Nordvall, Bengt Winblad, Erik Portelius, Helena Karlström
Journal of cellular and molecular medicine - 2022 -
Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimer's disease
diagnosis.
Thomas Karikari, Agathe Vrillon, Juan Lantero Rodriguez, Nicholas J. Ashton, Milica Gregorič Kramberger, Julien Dumurgier, Claire Hourregue, Saša Čučnik, Gunnar Brinkmalm, Uroš Rot, Henrik Zetterberg, Claire Paquet, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2021 -
Refining the amyloid beta peptide and oligomer fingerprint ambiguities in Alzheimer's disease: Mass spectrometric molecular characterization in brain, cerebrospinal fluid, blood, and
plasma
Wojciech Michno, Kaj Blennow, Henrik Zetterberg, Gunnar Brinkmalm
Journal of Neurochemistry - 2021 -
Brevican and Neurocan Peptides as Potential Cerebrospinal Fluid Biomarkers for Differentiation Between Vascular Dementia and Alzheimer's
Disease.
Karolina Minta, Gunnar Brinkmalm, Erik Portelius, Per Johansson, Johan Svensson, Petronella Kettunen, Anders Wallin, Henrik Zetterberg, Kaj Blennow, Ulf Andreasson
Journal of Alzheimer's disease : JAD - 2021 -
Molecular forms of neurogranin in cerebrospinal
fluid.
Faisal Hayat Nazir, Elena Camporesi, Gunnar Brinkmalm, Tammaryn Lashley, Christina E Toomey, Hlin Kvartsberg, Henrik Zetterberg, Kaj Blennow, Bruno Becker
Journal of neurochemistry - 2021 -
P-tau235: a novel biomarker for staging preclinical Alzheimer's
disease.
Juan Lantero Rodriguez, Anniina Snellman, Andréa Lessa Benedet, Marta Milà-Alomà, Elena Camporesi, Laia Montoliu-Gaya, Nicholas J. Ashton, Agathe Vrillon, Thomas Karikari, Juan Domingo Gispert, Gemma Salvadó, Mahnaz Shekari, Christina E Toomey, Tammaryn L Lashley, Henrik Zetterberg, Marc Suárez-Calvet, Gunnar Brinkmalm, Pedro Rosa Neto, Kaj Blennow
EMBO molecular medicine - 2021 -
Amyloid pathology and synaptic loss in pathological
aging
Eleni Gkanatsiou, Johanna Nilsson, C. E. Toomey, A. Vrillon, Hlin Kvartsberg, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm, T. Lashley, Gunnar Brinkmalm
Journal of Neurochemistry - 2021 -
Plasma ACE2 species are differentially altered in COVID-19
patients
M. S. Garcia-Ayllon, O. Moreno-Perez, J. Garcia-Arriaza, J. M. Ramos-Rincon, M. A. Cortes-Gomez, Gunnar Brinkmalm, M. Andres, J. M. Leon-Ramirez, V. Boix, J. Gil, Henrik Zetterberg, M. Esteban, E. Merino, J. Saez-Valero
FASEB Journal - 2021 -
Characterization of monomeric and soluble aggregated Aβ in Down's syndrome and Alzheimer's disease
brains.
Eleni Gkanatsiou, Charlotte Sahlin, Erik Portelius, Malin Johannesson, Linda Söderberg, Johanna Fälting, Hans Basun, Christer Möller, Tomas Odergren, Henrik Zetterberg, Kaj Blennow, Lars Lannfeldt, Gunnar Brinkmalm
Neuroscience letters - 2021 -
Plasma p-tau231: a new biomarker for incipient Alzheimer's disease
pathology.
Nicholas J. Ashton, Tharick A Pascoal, Thomas Karikari, Andréa Lessa Benedet, Juan Lantero Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blennow
Acta neuropathologica - 2021 -
Cerebrospinal fluid brevican and neurocan fragment patterns in human traumatic brain
injury.
Karolina Minta, Gunnar Brinkmalm, Eric P Thelin, Faiez Al Nimer, Fredrik Piehl, Mats Tullberg, Anna Jeppsson, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Ulf Andreasson
Clinica chimica acta; international journal of clinical chemistry - 2021 -
Cerebrospinal fluid biomarker panel for synaptic dysfunction in Alzheimer's
disease
Johanna Nilsson, Johan Gobom, Simon Sjödin, Gunnar Brinkmalm, Nicholas J. Ashton, Johan Svensson, Per Johansson, E. Portelius, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring - 2021 -
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human
brain
I. Alic, P. A. Goh, A. Murray, Erik Portelius, Eleni Gkanatsiou, G. Gough, K. Y. Mok, D. Koschut, R. Brunmeir, Y. J. Yeap, N. L. O'Brien, J. Groet, X. W. Shao, S. Havlicek, N. R. Dunn, Hlin Kvartsberg, Gunnar Brinkmalm, R. Hithersay, C. Startin, S. Hamburg, M. Phillips, K. Pervushin, M. Turmaine, D. Wallon, A. Rovelet-Lecrux, H. Soininen, E. Volpi, J. E. Martin, J. N. Foo, D. L. Becker, A. Rostagno, J. Ghiso, Z. Krsnik, G. Simic, I. Kostovi, D. Mitrecic, P. T. Francis, Kaj Blennow, A. Strydom, J. Hardy, Henrik Zetterberg, D. Nizetic
Molecular Psychiatry - 2021 -
Lumbar and ventricular CSF concentrations of extracellular matrix proteins before and after shunt surgery in idiopathic normal pressure
hydrocephalus
Karolina Minta, Anna Jeppsson, Gunnar Brinkmalm, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Mats Tullberg, Ulf Andreasson
Fluids and Barriers of the CNS - 2021 -
Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human
brain.
Ivan Alić, Pollyanna A Goh, Aoife Murray, Erik Portelius, Eleni Gkanatsiou, Gillian Gough, Kin Y Mok, David Koschut, Reinhard Brunmeir, Yee Jie Yeap, Niamh L O'Brien, Jürgen Groet, Xiaowei Shao, Steven Havlicek, N Ray Dunn, Hlin Kvartsberg, Gunnar Brinkmalm, Rosalyn Hithersay, Carla Startin, Sarah Hamburg, Margaret Phillips, Konstantin Pervushin, Mark Turmaine, David Wallon, Anne Rovelet-Lecrux, Hilkka Soininen, Emanuela Volpi, Joanne E Martin, Jia Nee Foo, David L Becker, Agueda Rostagno, Jorge Ghiso, Željka Krsnik, Goran Šimić, Ivica Kostović, Dinko Mitrečić, Paul T Francis, Kaj Blennow, Andre Strydom, John Hardy, Henrik Zetterberg, Dean Nižetić
Molecular psychiatry - 2021 -
Dynamics of cerebrospinal fluid levels of matrix metalloproteinases in human traumatic brain
injury.
Karolina Minta, Gunnar Brinkmalm, Faiez Al Nimer, Eric Thelin, Fredrik Piehl, Mats Tullberg, Anna Jeppsson, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Ulf Andreasson
Scientific reports - 2020 -
Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle
pathology.
Kaj Blennow, Chun Chen, Claudia Cicognola, Kristin R Wildsmith, Paul T Manser, Sandra M Sanabria Bohorquez, Zhentao Zhang, Boer Xie, Junmin Peng, Oskar Hansson, Hlin Kvartsberg, Erik Portelius, Henrik Zetterberg, Tammaryn Lashley, Gunnar Brinkmalm, Geoffrey A Kerchner, Robby M Weimer, Keqiang Ye, Kina Höglund
Brain : a journal of neurology - 2020 -
Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic
degeneration.
Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow
Neurobiology of disease - 2020 -
Tauopathy-Associated Tau Fragment Ending at Amino Acid 224 Is Generated by Calpain-2
Cleavage.
Claudia Cicognola, Tugce Munise Satir, Gunnar Brinkmalm, Irena Matečko-Burmann, Lotta Agholme, Petra Bergström, Bruno Becker, Henrik Zetterberg, Kaj Blennow, Kina Höglund
Journal of Alzheimer's disease : JAD - 2020 -
Quantification of total apolipoprotein E and its isoforms in cerebrospinal fluid from patients with neurodegenerative
diseases
Karolina Minta, Gunnar Brinkmalm, S. Janelidze, Simon Sjödin, Erik Portelius, E. Stomrud, Henrik Zetterberg, Kaj Blennow, O. Hansson, Ulf Andreasson
Alzheimer's Research & Therapy - 2020 -
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective
cohorts.
Thomas Karikari, Tharick A Pascoal, Nicholas J. Ashton, Shorena Janelidze, Andréa Lessa Benedet, Juan Lantero Rodriguez, Mira Chamoun, Melissa Savard, Min Su Kang, Joseph Therriault, Michael Schöll, Gassan Massarweh, Jean-Paul Soucy, Kina Höglund, Gunnar Brinkmalm, Niklas Mattsson, Sebastian Palmqvist, Serge Gauthier, Erik Stomrud, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Kaj Blennow
The Lancet. Neurology - 2020 -
Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer's and Parkinson's
disease
Simon Sjödin, Gunnar Brinkmalm, Annika Öhrfelt, L. Parnetti, S. Paciotti, O. Hansson, J. Hardy, Kaj Blennow, Henrik Zetterberg, Ann Brinkmalm
Alzheimer's Research & Therapy - 2019 -
Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral
sclerosis.
Inmaculada Lopez-Font, Aitana Sogorb-Esteve, Míriam Javier-Torrent, Gunnar Brinkmalm, Mireia Herrando-Grabulosa, Belen García-Lareu, Janina Turon-Sans, Ricardo Rojas-García, Alberto Lleó, Carlos A Saura, Henrik Zetterberg, Kaj Blennow, Assumpció Bosch, Xavier Navarro, Javier Sáez-Valero
Neurobiology of disease - 2019 -
Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1-40 deposition underlies plaque polymorphism in progressing Alzheimer's disease
pathology.
Wojciech Michno, Sofie Nyström, Patrick M. Wehrli, Tammaryn Lashley, Gunnar Brinkmalm, Laurent Guerard, Stina Syvänen, Dag Sehlin, Ibrahim Kaya, Dimitri Brinet, K Peter R Nilsson, Per Hammarström, Kaj Blennow, Henrik Zetterberg, Jörg Hanrieder
Journal of Biological Chemistry - 2019 -
Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein
fragments.
Marianne K O Grant, Maureen Handoko, Malgorzata Rozga, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Karen H Ashe, Kathleen R Zahs, Peng Liu
PloS one - 2019 -
Synthetic standard aided quantification and structural characterization of amyloid-beta glycopeptides enriched from cerebrospinal fluid of Alzheimer's disease
patients
Jonas Nilsson, Gunnar Brinkmalm, S. Ramadan, L. Gilborne, Fredrik Noborn, Kaj Blennow, Anders Wallin, Johan Svensson, M. A. Abo-Riyas, X. F. Huang, Göran Larson
Scientific Reports - 2019 -
A distinct brain beta amyloid signature in cerebral amyloid angiopathy compared to Alzheimer's
disease.
Eleni Gkanatsiou, Erik Portelius, Christina E Toomey, Kaj Blennow, Henrik Zetterberg, Tammaryn Lashley, Gunnar Brinkmalm
Neuroscience letters - 2019 -
Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's
disease.
Claudia Cicognola, Gunnar Brinkmalm, Johan Gobom, Jessica Wahlgren, Nicholas C Cullen, Lucilla Parnetti, Radu Constantinescu, Kristin Wildsmith, Hsu-Hsin Chen, Thomas G Beach, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Kina Höglund
Acta neuropathologica - 2019 -
Fluid-based proteomics targeted on pathophysiological processes and pathologies in neurodegenerative
diseases.
Ann Brinkmalm-Westman, Erik Portelius, Gunnar Brinkmalm, Josef Pannee, Rahil Dahlén, Johan Gobom, Kaj Blennow, Henrik Zetterberg
Journal of neurochemistry - 2019 -
Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's
brain
Gunnar Brinkmalm, W. Hong, Z. Wang, W. Liu, T. T. O'Malley, X. Sun, M. P. Frosch, D. J. Selkoe, Erik Portelius, Henrik Zetterberg, Kaj Blennow, D. M. Walsh
Brain - 2019 -
The intact postsynaptic protein neurogranin is reduced in brain tissue from patients with familial and sporadic Alzheimer's
disease.
Hlin Kvartsberg, Tammaryn Lashley, Christina E Murray, Gunnar Brinkmalm, Nicholas C Cullen, Kina Höglund, Henrik Zetterberg, Kaj Blennow, Erik Portelius
Acta neuropathologica - 2019 -
Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl
endopeptidase
Bruno Becker, Faisal Hayat Nazir, Gunnar Brinkmalm, Elena Camporesi, Hlin Kvartsberg, Erik Portelius, Martina Boström, Marie Kalm, Kina Höglund, Maria Olsson, Henrik Zetterberg, Kaj Blennow
Molecular Neurodegeneration - 2018 -
The presubiculum is preserved from neurodegenerative changes in Alzheimer's
disease
C. E. Murray, P. Gami-Patel, Eleni Gkanatsiou, Gunnar Brinkmalm, Erik Portelius, O. Wirths, W. Heywood, Kaj Blennow, J. Ghiso, J. L. Holton, K. Mills, Henrik Zetterberg, T. Revesz, T. Lashley
Acta Neuropathologica Communications - 2018 -
A Parallel Reaction Monitoring Mass Spectrometric Method for Analysis of Potential CSF Biomarkers for Alzheimer's
Disease.
Gunnar Brinkmalm, Simon Sjödin, Anja Hviid Simonsen, Steen Gregers Hasselbalch, Henrik Zetterberg, Ann Brinkmalm-Westman, Kaj Blennow
Proteomics. Clinical applications - 2018 -
Update on biomarkers for amyloid pathology in Alzheimer's
disease
Nicholas J. Ashton, Michael Schöll, Kerstin Heurling, Eleni Gkanatsiou, Erik Portelius, Kina Höglund, Gunnar Brinkmalm, A Hye, Kaj Blennow, Henrik Zetterberg
Biomarkers in medicine - 2018 -
Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer's
disease
F. H. Duits, Gunnar Brinkmalm, C. E. Teunissen, Ann Brinkmalm-Westman, P. Scheltens, W. M. Van der Flier, Henrik Zetterberg, Kaj Blennow
Alzheimers Research & Therapy - 2018 -
Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal
Fluid
Karl Hansson, Tobias Skillbäck, Elin Pernevik, Jessica Holmén Larsson, Gunnar Brinkmalm, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Jove-Journal of Visualized Experiments - 2017 -
Expanding the cerebrospinal fluid
endopeptidome
Karl Hansson, Tobias Skillbäck, Elin Pernevik, Silke Kern, Erik Portelius, Kina Höglund, Gunnar Brinkmalm, Jessica Holmén Larsson, Kaj Blennow, Henrik Zetterberg, Johan Gobom
Proteomics - 2017 -
Mass Spectrometric Analysis of Cerebrospinal Fluid Ubiquitin in Alzheimer's Disease and Parkinsonian
Disorders.
Simon Sjödin, Oskar Hansson, Annika Öhrfelt Olsson, Gunnar Brinkmalm, Henrik Zetterberg, Ann Brinkmalm-Westman, Kaj Blennow
Proteomics. Clinical applications - 2017 -
Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer's disease: an
update.
Erik Portelius, Gunnar Brinkmalm, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Rahil Dahlén, Ann Brinkmalm-Westman, Johan Gobom
Expert review of proteomics - 2017 -
Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric
Aβ.
Lotta Agholme, Marcus Clarin, Eleni Gkanatsiou, Petronella Kettunen, Jasmine Chebli, Gunnar Brinkmalm, Kaj Blennow, Petra Bergström, Erik Portelius, Henrik Zetterberg
Molecular and cellular neurosciences - 2017 -
The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's
disease
Annika Öhrfelt, Ann Brinkmalm-Westman, J. Dumurgier, Gunnar Brinkmalm, O. Hansson, Henrik Zetterberg, E. Bouaziz-Amar, J. Hugon, C. Paquet, Kaj Blennow
Alzheimers Research & Therapy - 2016 -
Targeting LAMP2 in human cerebrospinal fluid with a combination of immunopurification and high resolution parallel reaction monitoring mass
spectrometry.
Simon Sjödin, Annika Öhrfelt, Gunnar Brinkmalm, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm-Westman
Clinical proteomics - 2016 -
Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's
disease.
Hlin Kvartsberg, Flora H Duits, Martin Ingelsson, Niels Andreasen, Annika Öhrfelt, Kerstin Andersson, Gunnar Brinkmalm, Lars Lannfelt, Lennart Minthon, Oskar Hansson, Ulf Andreasson, Charlotte E Teunissen, Philip Scheltens, Wiesje M van der Flier, Henrik Zetterberg, Erik Portelius, Kaj Blennow
Alzheimer's & dementia : the journal of the Alzheimer's Association - 2015 -
The aqueous phase of Alzheimer's disease brain contains assemblies built from similar to 4 and similar to 7 kDa A beta
species
J. M. Mc Donald, T. T. O'Malley, W. Liu, A. J. Mably, Gunnar Brinkmalm, Erik Portelius, W. M. Wittbold, M. P. Frosch, D. M. Walsh
Alzheimers & Dementia - 2015 -
Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer's disease patients and healthy
controls
Hlin Kvartsberg, Erik Portelius, Ulf Andreasson, Gunnar Brinkmalm, K. Hellwig, N. Lelental, J. Kornhuber, O. Hansson, L. Minthon, P. Spitzer, J. M. Maler, Henrik Zetterberg, Kaj Blennow, P. Lewczuk
Alzheimers Research & Therapy - 2015 -
Explorative and targeted neuroproteomics in Alzheimer's
disease.
Ann Brinkmalm-Westman, Erik Portelius, Annika Öhrfelt, Gunnar Brinkmalm, Ulf Andreasson, Johan Gobom, Kaj Blennow, Henrik Zetterberg
Biochimica et biophysica acta - 2015 -
Heteromers of amyloid precursor protein in cerebrospinal
fluid.
Inmaculada Cuchillo-Ibañez, Inmaculada Lopez-Font, Alba Boix-Amorós, Gunnar Brinkmalm, Kaj Blennow, Jose-Luis Molinuevo, Javier Sáez-Valero
Molecular neurodegeneration - 2015 -
Assignment of Saccharide Identities through Analysis of Oxonium Ion Fragmentation Profiles in LC-MS/MS of
Glycopeptides.
Adnan Halim, Ulrika Westerlind, Christian Pett, Manuel Schorlemer, Ulla Rüetschi, Gunnar Brinkmalm, Carina Sihlbom, Johan Lengqvist, Göran Larson, Jonas Nilsson
Journal of proteome research - 2014 -
SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's
disease.
Ann Brinkmalm-Westman, Gunnar Brinkmalm, William G Honer, Lutz Frölich, Lucrezia Hausner, Lennart Minthon, Oskar Hansson, Anders Wallin, Henrik Zetterberg, Kaj Blennow, Annika Öhrfelt
Molecular neurodegeneration - 2014 -
Synthesis aided structural determination of amyloid-beta(1-15) glycopeptides, new biomarkers for Alzheimer's
disease
P. Wang, Jonas Nilsson, Gunnar Brinkmalm, Göran Larson, X. F. Huang
Chemical Communications - 2014 -
Targeting synaptic pathology with a novel affinity mass spectrometry
approach.
Ann Brinkmalm-Westman, Gunnar Brinkmalm, William G Honer, Julie A Moreno, Joel Jakobsson, Giovanna R Mallucci, Henrik Zetterberg, Kaj Blennow, Annika Öhrfelt
Molecular & cellular proteomics : MCP - 2014 -
The amyloid-β degradation pattern in plasma-A possible tool for clinical trials in Alzheimer's
disease
Josef Pannee, Ulrika Törnqvist, Annie Westerlund, M. Ingelsson, L. Lannfelt, Gunnar Brinkmalm, Rita Persson, Johan Gobom, Johan Svensson, Per Johansson, Henrik Zetterberg, Kaj Blennow, Erik Portelius
Neuroscience Letters - 2014 -
Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's
disease.
Erik Portelius, Maria Olsson, Gunnar Brinkmalm, Ulla Rüetschi, Niklas Mattsson, Ulf Andreasson, Johan Gobom, Ann Brinkmalm-Westman, Mikko Hölttä, Kaj Blennow, Henrik Zetterberg
Journal of Alzheimer's disease : JAD - 2013 -
CSF Presenilin-1 complexes are increased in Alzheimer's
disease.
María-Salud García-Ayllón, María-Letizia Campanari, Gunnar Brinkmalm, Alberto Rábano, Jordi Alom, Carlos A Saura, Niels Andreasen, Kaj Blennow, Javier Sáez-Valero
Acta neuropathologica communications - 2013 -
Cerebrospinal fluid biomarkers of β-amyloid metabolism in multiple
sclerosis.
Kristin Augutis, Markus Axelsson, Erik Portelius, Gunnar Brinkmalm, Ulf Andreasson, Mikael K Gustavsson, Clas Malmeström, Jan Lycke, Kaj Blennow, Henrik Zetterberg, Niklas Mattsson
Multiple sclerosis (Houndmills, Basingstoke, England) - 2013 -
Soluble amyloid precursor protein α and β in CSF in Alzheimer's
disease.
Gunnar Brinkmalm, Ann Brinkmalm-Westman, Philippe Bourgeois, Rita Persson, Oskar Hansson, Erik Portelius, Marc Mercken, Ulf Andreasson, Stéphane Parent, Francesco Lipari, Annika Öhrfelt, Maria Bjerke, Lennart Minthon, Henrik Zetterberg, Kaj Blennow, Magdalena Nutu
Brain research - 2013 -
Amyloid-β metabolism in Niemann-Pick C disease models and
patients.
Niklas Mattsson, Maria Olsson, Mikael K Gustavsson, Marko Kosicek, Martina Malnar, Jan-Eric Månsson, Maria K. Blomqvist, Johan Gobom, Ulf Andreasson, Gunnar Brinkmalm, Charles Vite, Silva Hecimovic, Caroline Hastings, Kaj Blennow, Henrik Zetterberg, Erik Portelius
Metabolic brain disease - 2012 -
BACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous
system.
Niklas Mattsson, Lawrence Rajendran, Henrik Zetterberg, Mikael K Gustavsson, Ulf Andreasson, Maria Olsson, Gunnar Brinkmalm, Johan Lundkvist, Laura H Jacobson, Ludovic Perrot, Ulf Neumann, Herman Borghys, Marc Mercken, Deborah Dhuyvetter, Fredrik Jeppsson, Kaj Blennow, Erik Portelius
PloS one - 2012 -
An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal
fluid.
Gunnar Brinkmalm, Erik Portelius, Annika Öhrfelt, Niklas Mattsson, Rita Persson, Mikael K Gustavsson, Charles H Vite, Johan Gobom, Jan-Eric Månsson, Jonas Nilsson, Adnan Halim, Göran Larson, Ulla Rüetschi, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm-Westman
Journal of mass spectrometry : JMS - 2012 -
Identification of Novel α-Synuclein Isoforms in Human Brain Tissue by using an Online NanoLC-ESI-FTICR-MS
Method.
Annika Öhrfelt Olsson, Henrik Zetterberg, Rita Persson, Dzemila Secic, Gunnar Brinkmalm, Anders Wallin, Ezra Mulugeta, Paul T Francis, Eugeen Vanmechelen, Dag Aarsland, Clive Ballard, Kaj Blennow, Ann Brinkmalm-Westman
Neurochemical research - 2011 -
A novel pathway for amyloid precursor protein
processing.
Erik Portelius, Erik Price, Gunnar Brinkmalm, Mark Stiteler, Maria Olsson, Rita Persson, Henrik Zetterberg, Ann Brinkmalm-Westman, Adam J Simon, Kaj Blennow
Neurobiology of aging - 2011 -
SILAC zebrafish for quantitative analysis of protein turnover and tissue
regeneration.
Ann Brinkmalm-Westman, Alexandra Abramsson, Josef Pannee, Chen Gang, Mikael K Gustavsson, Malin von Otter, Kaj Blennow, Gunnar Brinkmalm, Hermann Heumann, Henrik Zetterberg
Journal of proteomics - 2011 -
Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid {beta}-peptides in human cerebrospinal
fluid.
Adnan Halim, Gunnar Brinkmalm, Ulla Rüetschi, Ann Brinkmalm-Westman, Erik Portelius, Henrik Zetterberg, Kaj Blennow, Göran Larson, Jonas Nilsson
Proceedings of the National Academy of Sciences of the United States of America - 2011 -
Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal
fluid.
Erik Portelius, Gunnar Brinkmalm, Ai Jun Tran, Ulf Andreasson, Henrik Zetterberg, Ann Brinkmalm-Westman, Kaj Blennow, Annika Öhrfelt Olsson
Experimental neurology - 2010 -
Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's
disease.
Erik Portelius, Nenad Bogdanovic, Mikael K Gustavsson, Inga Volkmann, Gunnar Brinkmalm, Henrik Zetterberg, Bengt Winblad, Kaj Blennow
Acta neuropathologica - 2010 -
Proteomics Profiling of Single Organs from Individual Adult
Zebrafish.
Alexandra Abramsson, Ann Brinkmalm-Westman, Josef Pannee, Mikael K Gustavsson, Malin von Otter, Kaj Blennow, Gunnar Brinkmalm, Petronella Kettunen, Henrik Zetterberg
Zebrafish - 2010 -
Effects of gamma-Secretase Inhibition on the Amyloid beta Isoform Pattern in a Mouse Model of Alzheimer's
Disease.
Erik Portelius, Bin Zhang, Mikael K Gustavsson, Gunnar Brinkmalm, Ann Brinkmalm-Westman, Henrik Zetterberg, Virginia M-Y Lee, John Q Trojanowski, Kaj Blennow
Neuro-degenerative diseases - 2009 -
Enrichment of glycopeptides for glycan structure and attachment site
identification.
Jonas Nilsson, Ulla Rüetschi, Adnan Halim, Camilla Hesse, Elisabet Carlsohn, Gunnar Brinkmalm, Göran Larson
Nature methods - 2009 -
Proteomics/peptidomics tools to find CSF biomarkers for neurodegenerative
diseases.
Ann Brinkmalm-Westman, Ulla Rüetschi, Erik Portelius, Ulf Andreasson, Gunnar Brinkmalm, Gösta Karlsson, Sarah Hansson, Henrik Zetterberg, Kaj Blennow
Frontiers in bioscience : a journal and virtual library - 2009 -
Separation
Methods
Ann Brinkmalm-Westman, Jerzy Silberring, Gunnar Brinkmalm
Mass Spectrometry: Instrumentation, Interpretation, and Applications. Eds. Rolf Ekman, Jerzy Silberring, Ann Westman-Brinkmalm, Agnieszka Kraj - 2009 -
Tandem Mass
Spectrometry
Ann Brinkmalm-Westman, Gunnar Brinkmalm
Mass Spectrometry: Instrumentation, Interpretation, and Applications. Eds. Rolf Ekman, Jerzy Silberring, Ann Westman-Brinkmalm, Agnieszka Kraj - 2009 -
A Mass Spectrometer´s Building
Blocks
Ann Brinkmalm-Westman, Gunnar Brinkmalm
Mass Spectrometry: Instrumentation, Interpretation, and Applications. Eds. Rolf Ekman, Jerzy Silberring, Ann Westman-Brinkmalm, Agnieszka Kraj - 2009 -
Definitions and
Explanations
Ann Brinkmalm-Westman, Gunnar Brinkmalm
Mass Spectrometry: Instrumentation, Interpretation, and Applications. Eds. Rolf Ekman, Jerzy Silberring, Ann Westman-Brinkmalm, Agnieszka Kraj - 2009 -
Identification of novel APP/Abeta isoforms in human cerebrospinal
fluid.
Erik Portelius, Gunnar Brinkmalm, Ai Jun Tran, Henrik Zetterberg, Ann Brinkmalm-Westman, Kaj Blennow
Neuro-degenerative diseases - 2009 -
The applicability of enzymes in celluose ether
analysis
R Adden, C Melander, Gunnar Brinkmalm, M Knarr, P Engelhardt, P Mischnick
Macromolecular Symposia - 2008 -
Characterization of tau in cerebrospinal fluid using mass
spectrometry.
Erik Portelius, Sara Folkesson Hansson, Ai Jun Tran, Henrik Zetterberg, Pierre Grognet, Eugeen Vanmechelen, Kina Höglund, Gunnar Brinkmalm, Ann Brinkmalm-Westman, Eckhard Nordhoff, Kaj Blennow, Johan Gobom
Journal of proteome research - 2008 -
Clinical proteomics in neurodegenerative
disorders.
Henrik Zetterberg, Ulla Rüetschi, Erik Portelius, Gunnar Brinkmalm, Ulf Andreasson, Kaj Blennow, Ann Brinkmalm-Westman
Acta neurologica Scandinavica - 2008 -
Characterization of amyloid β peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass
spectrometry
Erik Portelius, Ai Jun Tran, Ulf Andreasson, Rita Persson, Gunnar Brinkmalm, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm-Westman
Journal of proteome research - 2007 -
Endoglucanase sensitivity for substituents in methyl cellulose hydrolysis studied using MALDI-TOFMS for oligosaccharide analysis and structural analysis of enzyme active
sites.
U Schagerlöf, H Schagerlöf, D Momcilovic, Gunnar Brinkmalm, F Tjerneld
Biomacromolecules - 2007 -
An Alzheimer's disease-specific beta-amyloid fragment signature in cerebrospinal
fluid.
Erik Portelius, Henrik Zetterberg, Ulf Andreasson, Gunnar Brinkmalm, Niels Andreasen, Anders Wallin, Ann Brinkmalm-Westman, Kaj Blennow
Neuroscience letters - 2006 -
Substituent distribution and clouding behavior of hydroxypropyl methyl cellulose analyzed using enzymatic
degradation.
Herje Schagerlöf, Marika Johansson, Sara Richardson, Gunnar Brinkmalm, Bengt Wittgren, Folke Tjerneld
Biomacromolecules - 2006