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- Jikui Guan
Jikui Guan
Researcher
Department of Medical Biochemistry and Cell biology-
ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR
inhibition
Marcus Borenäs, Ganesh Umapathy, Dan E. Lind, Wei-Yun Lai, Jikui Guan, Joel Johansson, Eva Jennische, Alexander Schmidt, Yeshwant Kurhe, Jonatan L. Gabre, Agata Aniszewska, Anneli Strömberg, Mats Bemark, Michael N. Hall, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer
Proceedings of the National Academy of Sciences of the United States of America - 2024 -
ALK F1174S mutation impairs ALK kinase activity in EML4-ALK variant 1 and sensitizes EML4-ALK variant 3 to
crizotinib
Jikui Guan, Tzu-Po Chuang, Anders Vikstrom, Ruth H. Palmer, Bengt Hallberg
FRONTIERS IN ONCOLOGY - 2024 -
IGF1R Contributes to Cell Proliferation in ALK-Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling
Pathway.
Jikui Guan, Marcus Borenäs, Junfeng Xiong, Wei-Yun Lai, Ruth H. Palmer, Bengt Hallberg
Cancers - 2023 -
Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase
Activation
D. Treis, Ganesh Umapathy, Susanne Fransson, Jikui Guan, Patricia Mendoza-García, Joachim T. Siaw, S. Wessman, L. G. Murkes, J. J. E. Stenman, Anna Djos, L. H. M. Elfman, J. I. Johnsen, Bengt Hallberg, Ruth H. Palmer, Tommy Martinsson, P. Kogner
JCO Precision Oncology - 2022 -
Chromosome imbalances in neuroblastoma—recent molecular insight into chromosome 1p-deletion, 2p-gain, and 11q-deletion identifies new friends and foes for the
future
Jikui Guan, Bengt Hallberg, Ruth H. Palmer
Cancers - 2021 -
ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK
mutation.
Marcus Borenäs, Ganesh Umapathy, Wei-Yun Lai, Dan E. Lind, Barbara Witek, Jikui Guan, Patricia Mendoza-García, Tafheem Masudi, Arne Claeys, Tzu-Po Chuang, Abeer El Wakil, Badrul Arefin, Susanne Fransson, Jan Koster, Mathias Johansson, Jennie Gaarder, Jimmy Van den Eynden, Bengt Hallberg, Ruth H. Palmer
The EMBO journal - 2021 -
Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK
Signaling
F. Aboualizadeh, Z. Yao, Jikui Guan, L. Drecun, S. Pathmanathan, J. Snider, Ganesh Umapathy, M. Kotlyar, I. Jurisica, Ruth H. Palmer, I. Stagljar
Journal of Molecular Biology - 2021 -
BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma
Cells
Ezgi Uçkun, Joachim T. Siaw, Jikui Guan, Vimala Anthonydhason, Johannes Fuchs, Georg Wolfstetter, Bengt Hallberg, Ruth H. Palmer
Journal of Molecular Biology - 2021 -
Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell
migration
H. Huang, A. Gont, L. Kee, R. Dries, K. Pfeifer, B. Sharma, D. N. Debruyne, M. Harlow, S. Sengupta, Jikui Guan, C. M. Yeung, W. C. Wang, Bengt Hallberg, Ruth H. Palmer, M. S. Irwin, R. E. George
Cell Reports - 2021 -
Loss of RET Promotes Mesenchymal Identity in Neuroblastoma
Cells
Joachim T. Siaw, Jonatan L. Gabre, Ezgi Uçkun, M. Vigny, W. C. Zhang, J. Van den Eynden, Bengt Hallberg, Ruth H. Palmer, Jikui Guan
Cancers - 2021 -
13P - Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic
pathways
Ganesh Umapathy, Jimmy Van den Eynden, Diana Lizeth Cervantes-Madrid, Joanna Szydzik, Jikui Guan, Ruth H. Palmer, Bengt Hallberg
Annals of oncology : official journal of the European Society for Medical Oncology. Vol. 30, Suppl. 1, p. i6 - 2019 -
Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor
ceritinib.
Jikui Guan, Susanne Fransson, Joachim T. Siaw, Diana Treis, Jimmy Van den Eynden, Damini Chand, Ganesh Umapathy, Kristina Ruuth, Alia Shamikh, Hans Jacobsson, Lena Gordon, Par-Johan Svensson, Magnus Hansson, Tommy Martinsson, Per Kogner, Ruth H. Palmer, Bengt Hallberg
Cold Spring Harbor molecular case studies - 2018 -
Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic
pathways.
Jimmy Van den Eynden, Ganesh Umapathy, Arghavan Ashouri, Diana Lizeth Cervantes-Madrid, Joanna Szydzik, Kristina Ruuth, Jan Koster, Erik Larsson, Jikui Guan, Ruth H. Palmer, Bengt Hallberg
Science signaling - 2018 -
ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived
cells.
Andrey Fadeev, Patricia Mendoza-García, Uwe Irion, Jikui Guan, Kathrin Pfeifer, Stephanie Wiessner, Fabrizio Serluca, Ajeet Pratap Singh, Christiane Nüsslein-Volhard, Ruth H. Palmer
Proceedings of the National Academy of Sciences of the United States of America - 2018 -
Novel Mechanisms of ALK Activation Revealed by Analysis of the Y1278S Neuroblastoma
Mutation.
Jikui Guan, Yasuo Yamazaki, Damini Chand, Jesper R van Dijk, Kristina Ruuth, Ruth H. Palmer, Bengt Hallberg
Cancers - 2017 -
MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted
neuroblastomas.
Ganesh Umapathy, Jikui Guan, Dan Gustafsson, Niloufar Javanmardi, Diana Lizeth Cervantes-Madrid, Anna Djos, Tommy Martinsson, Ruth H. Palmer, Bengt Hallberg
Science signaling - 2017 -
Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not
ligand-independent.
Jikui Guan, Georg Wolfstetter, Joachim T. Siaw, Damini Chand, Fredrik Hugosson, Ruth H. Palmer, Bengt Hallberg
Oncotarget - 2017 -
The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and
MYCN
Jikui Guan, E. R. Tucker, Haiying Wang, Damini Chand, L. S. Danielson, Kristina Ruuth, Abeer El Wakil, Barbara Witek, Y. Jamin, Ganesh Umapathy, S. P. Robinson, T. W. Johnson, T. Smeal, Tommy Martinsson, L. Chesler, Ruth H. Palmer, Bengt Hallberg
DMM Disease Models and Mechanisms - 2016 -
Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and
mice
Joachim T. Siaw, Haiying Wang, Kathrin Pfeifer, V. M. Rivera, Jikui Guan, Ruth H. Palmer, Bengt Hallberg
Oncotarget - 2016 -
FAM150A and FAM150B are activating ligands for Anaplastic Lymphoma
Kinase.
Jikui Guan, Ganesh Umapathy, Yasuo Yamazaki, Georg Wolfstetter, Patricia Mendoza, Kathrin Pfeifer, Ateequrrahman Mohammed, Fredrik Hugosson, Hongbing Zhang, Amy W Hsu, Robert Halenbeck, Bengt Hallberg, Ruth H. Palmer
eLife - 2015