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- Marica Ericson
Marica Ericson
Professor
Department of Chemistry & Molecular BiologyHead of Department
Swedish NMR CentreHead of Department
Department of Chemistry & Molecular BiologyAbout Marica Ericson
The interaction between light and matter is central to all life on Earth. We would for example not be able to exist, if it were not for the ability of plants to convert light into chemical energy. Physical chemistry – concerns with concepts and understanding related to the fundamental processes involved in light-matter interaction. But what happens to matter when light is concentrated in time and space, that is, when light from a laser with very short pulses of light is focused in matter? This creates non-linear optical interaction. Although this process is more complex to understand theoretically, it has already found applications.
My research is about how multiphoton microscopy, based on non-linear optical processes, can be applied for three-dimensional imaging of biological tissue. My research focus has been studies of human skin. The tissue is investigated three-dimensionally at microscopic level. In this way, we can investigate tissue, and study processes in a completely new way. I have explored the potential as diagnostic method as well as for drug delivery and toxicology studies. Presently, we are exploring how the technology can be combined with organ mimicking tissue cultures to study living tissue in real time.
I have a MSc in chemical engineering from Royal institute of Technology (1999) and PhD in Physical Chemistry from Chalmers University of Technology (2004). My thesis was about "Spectroscopic measurement for diagnosis and treatment of skin cancer". Since then I have worked with clinical research studies at the Dept. of Dermatology, Sahlgrenska University Hospital, and as a research assistant at the Department of Physics at the University of Gothenburg (GU) where I became associate professor in 2010. During the years 2010-2011 I was a visiting researcher at the University of Texas, Austin, USA. Since 2013 I am a teacher and researcher at the Department of Chemistry and Molecular Biology, and in autumn 2018 I was promoted to professor of physical chemistry.
As a teacher, I mainly teach courses in basic and physical chemistry (KEM011), but also have more specific courses aimed at pharmacy and biotoxicology with a focus on skin uptake (KER260 and KEA270), i.e. two optional courses in the prescription and pharmacy programs. I supervise PhD students, bachelors’ and masters’ students. I see a close connection between research and education, the ambition is that my research will contribute to society from several perspectives, both through the education of students and doctoral students, as well as with new knowledge for sustainable development. I am proud to work at GU and share the university's vision and work for a sustainable and democratic future.
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Molecular Mobility in Keratin-Rich Materials Monitored by Nuclear Magnetic Resonance: A Tool for the Evaluation of Structure-Giving
Properties
M. Gunnarsson, S. Larsson, Monika Malak, Marica B Ericson, D. Topgaard, E. Sparr
Biomacromolecules - 2023 -
Membrane permeability based on mesh
analysis
B. Stenqvist, Marica B Ericson, S. Gregoire, B. Biatry, G. Cassin, M. Jankunec, J. Engblom, E. Sparr
Journal of Colloid and Interface Science - 2023 -
Contribution of autofluorescence from intracellular proteins in multiphoton fluorescence lifetime
imaging.
Monika Malak, Jeemol James, Julie Grantham, Marica B Ericson
Scientific reports - 2022 -
Fluorescence Correlation Spectroscopy Combined with Multiphoton Laser Scanning Microscopy-A Practical
Guideline
Jeemol James, Jonas Enger, Marica B Ericson
Applied Sciences - 2021 -
Can mesoporous nanoparticles promote bioavailability of topical
pharmaceutics?
S. Valetti, H. Thomsen, J. Wankar, P. Falkman, I. Manet, A. Feiler, Marica B Ericson, J. Engblom
International Journal of Pharmaceutics - 2021 -
Cellulose acetate encapsulated upconversion nanoparticles – A novel theranostic
platform
S. D. Topel, S. Balcioglu, B. Ateş, M. Asilturk, Ö Topel, Marica B Ericson
Materials Today Communications - 2021 -
Monitoring calcium-induced epidermal differentiation in vitro using multiphoton
microscopy
Monika Malak, Julie Grantham, Marica B Ericson
Journal of Biomedical Optics - 2020 -
Report on fluorescence lifetime imaging using multiphoton laser scanning microscopy targeting sentinel lymph node
diagnostics.
Jeemol James, Despoina Kantere, Jonas Enger, Ann-Marie Wennberg, Marica B Ericson
Journal of biomedical optics - 2020 -
Increased antibiotic efficacy and noninvasive monitoring of Staphylococcus epidermidis biofilms using per-cysteamine-substituted γ-cyclodextrin - A delivery effect validated by fluorescence
microscopy.
Hanna Thomsen, Marco Agnes, Owens Uwangue, Linnèa Persson, Matilda Mattsson, Fabrice Graf, Eleni-Marina Kasimati, Konstantina Yannakopoulou, Marica B Ericson, Anne Farewell
International journal of pharmaceutics - 2020 -
Self-Assembly of Mechanoplasmonic Bacterial Cellulose-Metal Nanoparticle
Composites
O. Eskilson, S. B. Lindstrom, B. Sepulveda, M. M. Shahjamali, P. Guell-Grau, P. Sivler, M. Skog, C. Aronsson, E. M. Bjork, N. Nyberg, H. Khalaf, T. Bengtsson, Jeemol James, Marica B Ericson, E. Martinsson, R. Selegard, D. Aili
Advanced Functional Materials - 2020 -
Label-free laser scanning microscopy targeting sentinel lymph node diagnostics: A feasibility study ex
vivo
Despoina Kantere, Jan Siarov, Shahin De Lara, Samad Parhizkar, Roger Olofsson Bagge, Ann-Marie Wennberg Larkö, Marica B Ericson
Translational Biophotonics - 2020 -
Optimizing Ti:Sapphire laser for quantitative biomedical
imaging
Jeemol James, Hanna Thomsen, Dag Hanstorp, Felipe Ademir Alemán Hérnandez, Sebastian Rothe, Jonas Enger, Marica B Ericson
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 1049824 - 2018 -
Spatially confined photoinactivation of bacteria: Towards novel tools for detailed mechanistic
studies
Hanna Thomsen, Jeemol James, Anne Farewell, Marica B Ericson
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Multiphoton Microscopy in the Biomedical Sciences XVIII 2018; San Francisco; United States; 28 January 2018 through 30 January 2018. Vol 10498 - 2018 -
Exploring photoinactivation of microbial biofilms using laser scanning microscopy and confined two-photon
excitation.
Hanna Thomsen, Fabrice Graf, Anne Farewell, Marica B Ericson
Journal of biophotonics - 2018 -
Exploring plasmonic coupling as a stimuli responsive contrast mechanism in multiphoton
microscopy
Marica B Ericson, Hanna Thomsen, Jeemol James, Vladimir Kirejev, D. Aili, A. Vargas-Berenguel
Proceedings Volume 10509, Plasmonics in Biology and Medicine XV - 2018 -
Confined photo-release of nitric oxide with simultaneous two-photon fluorescence tracking in a cellular
system
Hanna Thomsen, N. Marino, S. Conoci, S. Sortino, Marica B Ericson
Scientific Reports - 2018 -
Imaging mass spectrometry for novel insights into contact allergy – a proof-of-concept study on
nickel
Per Malmberg, Thomas Guttenberg, Marica B Ericson, Lina Hagvall
Contact Dermatitis - 2018 -
Monitoring the release of a NO photodonor from polymer nanoparticles: Via Förster resonance energy transfer and two-photon fluorescence
imaging
C. Conte, A. Fraix, Hanna Thomsen, F. Ungaro, V. Cardile, A. C. E. Graziano, Marica B Ericson, F. Quaglia, S. Sortino
Journal of Materials Chemistry B - 2018 -
Mesoporous silica particles as a lipophilic drug vehicle investigated by fluorescence lifetime
imaging
S. Valetti, J. Wankar, Marica B Ericson, A. Feiler, I. Manet
Journal of Materials Chemistry B - 2017 -
Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium in Multiphoton
Microscopy
Johan Borglin, R. Selegard, D. Aili, Marica B Ericson
Nano Letters - 2017 -
Delivery of cyclodextrin polymers to bacterial biofilms - An exploratory study using rhodamine labelled cyclodextrins and multiphoton
microscopy
Hanna Thomsen, Gábor Benkovics, Éva Fenyvesi, Anne Farewell, Milo Malanga, Marica B Ericson
International Journal of Pharmaceutics - 2017 -
Imaging of Photosensitizers in
Skin
Marica B Ericson, Danni Wang, Despoina Kantere, John Paoli, Ann-Marie Wennberg
Imaging in Photodynamic Therapy. Eds: Michael R. Hamblin, Yingying Huang - 2017 -
Annular Beam Shaping in Multiphoton Microscopy to Reduce Out-of-Focus
Background
Johan Borglin, Danni Wang, N. J. Durr, Dag Hanstorp, A. Ben-Yakar, Marica B Ericson
International Journal of Spectroscopy - 2017 -
Insights on proximity effect and multiphoton induced luminescence from gold nanospheres in far field optical
microscopy
Johan Borglin, Stina Guldbrand, Hanne Evenbratt, Vladimir Kirejev, Henrik Grönbeck, Marica B Ericson
Applied Physics Letters - 2015 -
Improving multiphoton microscopy using annular beam shaping, focusing on imaging of human
skin
Johan Borglin, N.J. Durr, Stina Guldbrand, O. Ferhanoǧlu, Ann-Marie Wennberg, Dag Hanstorp, A. Ben-Yakar, Marica B Ericson
Multiphoton Microscopy in the Biomedical Sciences XIV: 2-4 February 2014, San Francisco, California, United States. Progress in Biomedical Optics and Imaging - Proceedings of SPIE - 2014 -
Poor correlation between spectrophotometric intracutaneous analysis and histopathology in melanoma and nonmelanoma
lesions.
Karin Terstappen, Mart Suurküla, Håkan Hallberg, Marica B Ericson, Ann-Marie Wennberg
Journal of Biomedical Optics - 2013 -
Errata: Poor correlation between spectrophotometric intracutaneous analysis and histopathology in melanoma and nonmelanoma
lesions.
Karin Terstappen, Mart Suurküla, Håkan Hallberg, Marica B Ericson, Ann-Marie Wennberg
Journal of Biomedical Optics - 2013 -
Anti-Stokes fluorescence from endogenously formed protoporphyrin IX - Implications for clinical multiphoton
diagnostics.
Despoina Kantere, Stina Guldbrand, John Paoli, Mattias Goksör, Dag Hanstorp, Ann-Marie Wennberg, Maria Smedh, Marica B Ericson
Journal of biophotonics - 2013 -
Multiphoton microscopy – a powerful tool in skin research and topical drug delivery
science
Vladimir Kirejev, Stina Guldbrand, Johan Borglin, Carl Simonsson, Marica B Ericson
Journal of Drug Delivery Science and Technology - 2012 -
Modification and expulsion of keratins by human epidermal keratinocytes upon hapten exposure in
vitro.
Brigitte Bauer, Sofia Andersson, Anna-Lena Stenfeldt, Carl Simonsson, Jörgen Bergström, Marica B Ericson, Charlotte A Jonsson, Kerstin S Broo
Chemical research in toxicology - 2011 -
Caged fluorescent haptens reveal the generation of cryptic epitopes in allergic contact
dermatitis.
Carl Simonsson, Sofia Andersson, Anna-Lena Stenfeldt, Jörgen Bergström, Brigitte Bauer, Charlotte A Jonsson, Marica B Ericson, Kerstin S Broo
The Journal of investigative dermatology - 2011 -
Accumulation of FITC near stratum corneum-visualizing epidermal distribution of a strong sensitizer using two-photon
microscopy
Kristin Samuelsson, Carl Simonsson, Charlotte A Jonsson, Gunnar Westman, Marica B Ericson, Ann-Therese Karlberg
Contact Dermatitis - 2009 -
Single Low-dose Red Light is as Efficacious as Methyl-aminolevulinate-Photodynamic Therapy for Treatment of Acne: Clinical Assessment and Fluorescence
Monitoring
Camilla Hörfelt, Bo Stenquist, Christina Halldin, Marica B Ericson, Ann-Marie Wennberg
Acta Dermato-Venereologica - 2009 -
Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic
surgery
Bo Stenquist, Marica B Ericson, C. Strandeberg, Lena Mölne, Arne Rosen, Olle Larkö, Ann-Marie Wennberg
Br J Dermatol - 2006 -
Lipid cubic phases for improved topical drug delivery in photodynamic
therapy.
Johanna Bender, Marica B Ericson, Nadia Merclin, V. Iani, Arne Rosen, Sven Engström, J. Moan
Journal of Controlled Release - 2005