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Mario Ruiz
Researcher
Core facilities-
Aging AdipoR2-deficient mice are hyperactive with enlarged brains excessively rich in saturated fatty
acids
Mario Ruiz, Ranjan Devkota, Per-Olof Bergh, Ali Moussavi Nik, Sebastian Sköldheden, Jorge Mondejar-Duran, Maximilian Tufvesson-Alm, Mohammad Bohlooly-Y, Diego Sanchez, Peter Carlsson, Marcus Henricsson, Elisabeth Jerlhag, Jan Borén, Marc Pilon
The FASEB Journal - 2024 -
Regulation of meiotic telomere dynamics through membrane fluidity promoted by
AdipoR2-ELOVL2
Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanovic, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernandez-Hernandez, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya
NATURE COMMUNICATIONS - 2024 -
AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane
fluidity
Mario Ruiz, Ranjan Devkota, Delaney Kaper, Hanna Ruhanen, Kiran Busayavalasa, Uros Radovic, Marcus Henricsson, Reijo Käkelä, Jan Borén, Marc Pilon
Journal of Biological Chemistry - 2023 -
Striking membrane defects in AdipoR-deficient
cells
Mario Ruiz, Dimitra Panagaki, Johanna L Höög, Marc Pilon
Journal of lipid research - 2023 -
PAQR proteins and the evolution of a superpower: Eating all kinds of fats Animals rely on evolutionarily conserved membrane homeostasis proteins to compensate for dietary
variation
Marc Pilon, Mario Ruiz
Bioessays - 2023 -
Elevated Adipocyte Membrane Phospholipid Saturation Does Not Compromise Insulin
Signaling
Henrik Palmgren, Kasparas Petkevicius, Stefano Bartesaghi, Andrea Ahnmark, Mario Ruiz, Ralf Nilsson, Lars Loefgren, Matthew S. Glover, Anne-Christine Andreasson, Liselotte Andersson, Cécile Becquart, Michael Kurczy, Bengt Kull, Simonetta Wallin, Daniel Karlsson, Sonja Hess, Marcello Maresca, Mohammad Bohlooly-Y, Xiao-Rong Peng, Marc Pilon
DIABETES - 2023 -
Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart
function.
Marion Laudette, Malin Lindbom, Muhammad Arif, Mathieu Cinato, Mario Ruiz, Stephen Doran, Azra Miljanovic, Mikael Rutberg, Linda Andersson, Martina Klevstig, Marcus Henricsson, Per-Olof Bergh, Entela Bollano, Nay Aung, J. Gustav Smith, Marc Pilon, Tuulia Hyötyläinen, Matej Orešič, Rosie Perkins, Adil Mardinoglu, Malin Levin, Jan Borén
Cardiovascular research - 2023 -
Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and
embryogenesis.
Mario Ruiz, Ranjan Devkota, Dimitra Panagaki, Per-Olof Bergh, Delaney Kaper, Marcus Henricsson, Ali Nik, Kasparas Petkevicius, Johanna L Höög, Mohammad Bohlooly-Y, Peter Carlsson, Jan Borén, Marc Pilon
Nature communications - 2022 -
A small molecule screen for paqr-2 suppressors identifies Tyloxapol as a membrane fluidizer for C. elegans and mammalian
cells
Mario Ruiz, Emma Svensk, Elinor Einarsson, Erik Podda Grahn, Marc Pilon
Biochimica Et Biophysica Acta-Biomembranes - 2022 -
Treatment with HIV-protease inhibitor nelfinavir identifies membrane lipid composition and fluidity as a therapeutic target in advanced multiple
myeloma
Lenka Besse, Andrej Besse, Sara C. Stolze, Amin Sobh, Esther A. Zaal, Alwin J.Van Der Ham, Mario Ruiz, Santosh Phuyal, Lorina Buchler, Marc Sathianathan, Bogdan I. Florea, Jan Borén, Marcus Ståhlman, Julia Huber, Arnold Bolomsky, Heinz Ludwig, J. Thomas Hannich, Alex Loguinov, Bart Everts, Celia R. Berkers, Marc Pilon, Hesso Farhan, Christopher D. Vulpe, Herman S. Overkleeft, Christoph Driessen
Cancer Research - 2021 -
Palmitic acid causes increased dihydroceramide levels when desaturase expression is directly silenced or indirectly lowered by silencing
AdipoR2
Mario Ruiz, Marcus Henricsson, Jan Borén, Marc Pilon
Lipids in Health and Disease - 2021 -
Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty
acids
Mario Ruiz, H. Palmgren, Marcus Henricsson, Ranjan Devkota, H. Jaiswal, M. Maresca, M. Bohlooly-Y, X. R. Peng, Jan Borén, Marc Pilon
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids - 2021 -
Into the Labyrinth of the Lipocalin alpha 1-Acid
Glycoprotein
Mario Ruiz
Frontiers in Physiology - 2021 -
Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR
proteins
Kiran Busayavalasa, Mario Ruiz, Ranjan Devkota, Marcus Ståhlman, Rakesh Bodhicharla, Emma Svensk, N. O. Hermansson, Jan Borén, Marc Pilon
Plos Genetics - 2020 -
Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and
fluidity
Mario Ruiz, Rakesh Bodhicharla, Marcus Ståhlman, Emma Svensk, Kiran Busayavalasa, H. Palmgren, H. Ruhanen, Jan Borén, Marc Pilon
Elife - 2019 -
AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of
adiponectin
Mario Ruiz, Marcus Ståhlman, Jan Borén, Marc Pilon
Journal of Lipid Research - 2019 -
Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditis elegans PAQR-2 and Its Mammalian Homolog
AdipoR2
Rakesh Bodhicharla, Ranjan Devkota, Mario Ruiz, Marc Pilon
Genetics - 2018 -
Membrane fluidity is regulated by the C-elegans transmembrane protein FLD-1 and its human homologs
TLCD1/2
Mario Ruiz, Rakesh Bodhicharla, Emma Svensk, Ranjan Devkota, Kiran Busayavalasa, Henrik Palmgren, Marcus Ståhlman, Jan Borén, Marc Pilon
eLife - 2018 -
The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty
acids.
Ranjan Devkota, Emma Svensk, Mario Ruiz, Marcus Ståhlman, Jan Borén, Marc Pilon
PLoS genetics - 2017