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Ranjan Devkota
Researcher
Core facilities-
Aging AdipoR2-deficient mice are hyperactive with enlarged brains excessively rich in saturated fatty
acids
Mario Ruiz, Ranjan Devkota, Per-Olof Bergh, Ali Moussavi Nik, Sebastian Sköldheden, Jorge Mondejar-Duran, Maximilian Tufvesson-Alm, Mohammad Bohlooly-Y, Diego Sanchez, Peter Carlsson, Marcus Henricsson, Elisabeth Jerlhag, Jan Borén, Marc Pilon
The FASEB Journal - 2024 -
Regulation of meiotic telomere dynamics through membrane fluidity promoted by
AdipoR2-ELOVL2
Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanovic, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernandez-Hernandez, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya
NATURE COMMUNICATIONS - 2024 -
AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane
fluidity
Mario Ruiz, Ranjan Devkota, Delaney Kaper, Hanna Ruhanen, Kiran Busayavalasa, Uros Radovic, Marcus Henricsson, Reijo Käkelä, Jan Borén, Marc Pilon
Journal of Biological Chemistry - 2023 -
Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and
embryogenesis.
Mario Ruiz, Ranjan Devkota, Dimitra Panagaki, Per-Olof Bergh, Delaney Kaper, Marcus Henricsson, Ali Nik, Kasparas Petkevicius, Johanna L Höög, Mohammad Bohlooly-Y, Peter Carlsson, Jan Borén, Marc Pilon
Nature communications - 2022 -
A genetic titration of membrane composition in Caenorhabditis elegans reveals its importance for multiple cellular and physiological
traits
Ranjan Devkota, Delaney Kaper, Rakesh Bodhicharla, Marcus Henricsson, Jan Borén, Marc Pilon
Genetics - 2021 -
The C. elegans PAQR-2 and IGLR-2 membrane homeostasis proteins are uniquely essential for tolerating dietary saturated
fats
Ranjan Devkota, Marcus Henricsson, Jan Borén, Marc Pilon
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids - 2021 -
Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty
acids
Mario Ruiz, H. Palmgren, Marcus Henricsson, Ranjan Devkota, H. Jaiswal, M. Maresca, M. Bohlooly-Y, X. R. Peng, Jan Borén, Marc Pilon
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids - 2021 -
Leveraging a gain-of-function allele of Caenorhabditis elegans paqr-1 to elucidate membrane homeostasis by PAQR
proteins
Kiran Busayavalasa, Mario Ruiz, Ranjan Devkota, Marcus Ståhlman, Rakesh Bodhicharla, Emma Svensk, N. O. Hermansson, Jan Borén, Marc Pilon
Plos Genetics - 2020 -
The Caenorhabditis elegans homolog of human copper chaperone Atox1, CUC-1, aids in distal tip cell
migration
X. L. Zhang, S. Blockhuys, Ranjan Devkota, Marc Pilon, P. Wittung-Stafshede
Biometals - 2020 -
Membrane Fluidity Regulation: From C. elegans to mammalian
cells
Ranjan Devkota
2020 -
Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditis elegans PAQR-2 and Its Mammalian Homolog
AdipoR2
Rakesh Bodhicharla, Ranjan Devkota, Mario Ruiz, Marc Pilon
Genetics - 2018 -
Membrane fluidity is regulated by the C-elegans transmembrane protein FLD-1 and its human homologs
TLCD1/2
Mario Ruiz, Rakesh Bodhicharla, Emma Svensk, Ranjan Devkota, Kiran Busayavalasa, Henrik Palmgren, Marcus Ståhlman, Jan Borén, Marc Pilon
eLife - 2018 -
FRAP: A Powerful Method to Evaluate Membrane Fluidity in Caenorhabditis
elegans
Ranjan Devkota, Marc Pilon
Bio-Protocol - 2018 -
The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty
acids.
Ranjan Devkota, Emma Svensk, Mario Ruiz, Marcus Ståhlman, Jan Borén, Marc Pilon
PLoS genetics - 2017 -
Regulation of Axon Guidance by the Wnt Receptor Ror/CAM-1 in the PVT Guidepost Cell in Caenorhabditis
elegans
Jason Chien, Ranjan Devkota, N. Yosef, Catarina Mörck
Genetics - 2017 -
Caenorhabditis elegans PAQR-2 and IGLR-2 protect against glucose toxicity by modulating membrane lipid
composition
Emma Svensk, Ranjan Devkota, Marcus Ståhlman, Parmida Ranji, Manish Rauthan, Fredrik Magnusson, Sofia Hammarsten, Maja Johansson, Jan Borén, Marc Pilon
PLoS Genetics - 2016