– I have a background in molecular biology and began my journey into bioinformatics and genomics during my PhD with Professor Ann-Mari Svennerholm and Professor Gordon Dougan (Wellcome Sanger Institute). My combined expertise in molecular biology and bioinformatics allows me to study antibiotic resistance at both molecular and genomic levels. Antibiotic resistance has been a central focus of our genome analysis, examining how resistance patterns evolve over time and across regions, providing valuable insights into the spread and evolution of resistance, says von Mentzer.
Exploring bacterial spread and genetic diversity through genomics and AI
– My research focuses on the transmission of pathogenic bacteria between hosts, both directly and indirectly via the environment. This involves not only bacterial spread but also the transfer of genetic material, such as plasmids and mobile elements. So far, I’ve focused on large-scale genomic analyses, including phylogenetics, comparative genomics, and machine learning.
– We use machine learning to analyse bacterial genome clusters, applying advanced algorithms to study both core and accessory genomes, helping us to better understand bacterial diversity and evolution. In my new role, I’ll focus more on using AI to predict virulence factors and identify new E. coli variants. We’ll also study the genomic traits that determine whether a bacterium can colonise a single host or multiple hosts, such as humans and pigs.
Global collaborations and mentorship
– My extensive international collaborations with Kenya, Zambia, India, and Bangladesh bring a unique network to CARe, along with valuable samples and sequence data. These partnerships enable studies on antibiotic resistance across various geographical and socio-economic contexts, which is crucial for understanding the global spread of resistance. I also collaborate with the Wellcome Sanger Institute in Cambridge, a world-leading genomics centre, where I am a visiting researcher.
– To make the most of these data, I am currently building a searchable E. coli database that includes all the sequence data I have contributed to or analysed. This database will be a valuable resource for CARe, offering quick access to comprehensive genomic data related to antibiotic resistance. More details on this database and its integration into CARe’s research infrastructure will be shared soon.
Embracing collaboration and innovation through the DDLS Programme
– I’m excited to join a close-knit network of young researchers, navigating similar challenges in academia. After attending a DDLS retreat, I was impressed by the supportive atmosphere within the group. Specifically, I look forward to:
• Interdisciplinary collaborations: I’ve already identified potential projects with DDLS fellows.
• Skill development: DDLS offers specialised courses in data-driven life sciences, which my group will benefit from.
• Mentorship and networking: The programme provides access to experienced mentors and a broad life sciences network, crucial for my career.
• Resources and infrastructure: DDLS offers access to advanced technical infrastructure, which will accelerate our research.
– For PhD students and postdocs joining the von Mentzer Lab, I hope am confident they’ll benefit from the DDLS community, accessing courses and participating in valuable exchanges. This will strengthen our group and foster a dynamic research environment.
Two PhD positions and one postdoctoral position will be announced shortly. Interested candidates are welcome to contact Astrid von Mentzer directly.
