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Helen Lindqvist
Senior Lecturer
Department of Internal Medicine and Clinical NutritionAbout Helen Lindqvist
Associate Professor Helen Lindqvist's research focuses on biomarkers from food (metabolomics) and how diet influence disease acitivity and inflammation in patients with Rheumatoid Arthritis.
She defended her dissertation in 2008 at Chalmers University of Technology, and the thesis focused on high quality dietary interventions and risk factors for cardiovascular disease, already then reflecting an interest in biomarkers that could be used as markers for dietary compliance. Her work within metabolomics started together with Anna Winkvist and co-workers at the Swedish NMR Center in 2011. Today her work within dietary metabolite patterns covers post-prandial studies, dietary cross-over intervention studies, and cohort studies. Focus has been on finding patterns of metabolites in both serum and urine samples that separate different diet regimens such as high and low intake of food from animal sources.
Since many years she has also focused on how diet influences patients with rheumatoid arthritis. She has been the PI for the clinical intervention studies: MIRA-Mussels, Inflammation och Rheumatoid Arthritis, ADIRA- Anti-inflammatory Diet, Inflammation and Rheumatoid Arthritis and PIRA- Postprandial Inflammation in Rheumatoid Arthritis. Also, in this field metabolomics has been used as a tool to find metabolites that could both reflect dietary compliance but also discriminate between responders and non-responders.
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A randomized controlled cross-over trial investigating the acute inflammatory and metabolic response after meals based on red meat, fatty fish, or soy protein: the postprandial inflammation in rheumatoid arthritis (PIRA)
trial.
Erik Hulander, Linnea Bärebring, Anna Winkvist, Inger Gjertsson, Helen Lindqvist
European Journal of Nutrition - 2024 -
Towards objective measurements of habitual dietary intake patterns: comparing NMR metabolomics and food frequency questionnaire data in a population-based
cohort
Anna Winkvist, Ingegerd Johansson, Lars Ellegård, Helen Lindqvist
NUTRITION JOURNAL - 2024 -
Blending Samples to Increase Accuracy and Precision of 1H NMR Urine
Metabolomics
Anders Bay Nord, Helen Lindqvist, Millie Rådjursöga, Anna Winkvist, B Göran Karlsson, Daniel Malmodin
ANALYTICAL CHEMISTRY - 2024 -
Exploring the differences in serum metabolite profiles after intake of red meat in women with rheumatoid arthritis and a matched control
group
Helen Lindqvist, Inger Gjertsson, Erik Hulander, Linnea Bärebring, Anna Winkvist
European Journal of Nutrition - 2024 -
Dietary biomarkers and food records indicate compliance to study diets in the ADIRA (Anti-inflammatory Diet In Rheumatoid Arthritis)
trial
Anna Turesson Wadell, Linnea Bärebring, Erik Hulander, Inger Gjertsson, R. Landberg, Helen Lindqvist, Anna Winkvist
FRONTIERS IN NUTRITION - 2023 -
Influence of Dietary n-3 Long Chain Polyunsaturated Fatty Acid Intake on Oxylipins in Erythrocytes of Women with Rheumatoid
Arthritis
Helen Lindqvist, Anna Winkvist, Inger Gjertsson, P. C. Calder, A. M. Armando, O. Quehenberger, R. Coras, M. Guma
Molecules - 2023 -
Orthorexia Nervosa Practices in Rheumatoid Arthritis: The DORA
Study
M. Sifakaki, K. Gkiouras, Helen Lindqvist, G. Marakis, A. Petropoulou, L. M. Donini, D. P. Bogdanos, M. G. Grammatikopoulou
Nutrients - 2023 -
Ceramides in Autoimmune Rheumatic Diseases: Existing Evidence and Therapeutic Considerations for Diet as an Anticeramide
Treatment
I. Alexandropoulou, M. G. Grammatikopoulou, K. K. Gkouskou, A. A. Pritsa, T. Vassilakou, E. Rigopoulou, Helen Lindqvist, D. P. Bogdanos
Nutrients - 2023 -
Identification of Single and Combined Serum Metabolites Associated with Food
Intake
Therese Karlsson, Anna Winkvist, Millie Rådjursöga, Lars Ellegård, Anders Pedersen, Helen Lindqvist
Metabolites - 2022 -
Inadequate Dietary Nutrient Intake in Patients With Rheumatoid Arthritis in Southwestern Sweden: A Cross-Sectional
Study
Anna Turesson Wadell, Linnea Bärebring, Erik Hulander, Inger Gjertsson, Helen Lindqvist, Anna Winkvist
Frontiers in Nutrition - 2022 -
Improvements in Body Composition after a Proposed Anti-Inflammatory Diet Are Modified by Employment Status in Weight-Stable Patients with Rheumatoid Arthritis, a Randomized Controlled Crossover
Trial
Erik Hulander, Helen Lindqvist, Anna Turesson Wadell, Inger Gjertsson, Anna Winkvist, Linnea Bärebring
Nutrients - 2022 -
Validity of bioimpedance for assessment of fat-free mass in women with Rheumatoid Arthritis compared to non-rheumatic
controls
Helen Lindqvist, O. Wallengren, Anders Eriksson, Erik Hulander, Anna Winkvist, Linnea Bärebring
Clinical Nutrition Espen - 2022 -
Proposed Anti-Inflammatory Diet Reduces Inflammation in Compliant, Weight-Stable Patients with Rheumatoid Arthritis in a Randomized Controlled Crossover
Trial
Erik Hulander, Linnea Bärebring, Anna Turesson Wadell, Inger Gjertsson, P. C. Calder, Anna Winkvist, Helen Lindqvist
Journal of Nutrition - 2021 -
A Randomized Controlled Dietary Intervention Improved the Serum Lipid Signature towards a Less Atherogenic Profile in Patients with Rheumatoid
Arthritis
Helen Lindqvist, Linnea Bärebring, Inger Gjertsson, A. Jylha, R. Laaksonen, Anna Winkvist, M. Hilvo
Metabolites - 2021 -
Effects on health-related quality of life in the randomized, controlled crossover trial ADIRA (Anti-inflammatory Diet In Rheumatoid
Arthritis).
Anna Turesson Wadell, Linnea Bärebring, Erik Hulander, Inger Gjertsson, Lars Hagberg, Helen Lindqvist, Anna Winkvist
PloS one - 2021 -
Changes in serum and urinary metabolomic profile after a dietary intervention in patients with irritable bowel
syndrome
Sanna Nybacka, Magnus Simrén, Stine Störsrud, Hans Törnblom, Anna Winkvist, Helen Lindqvist
PLoS ONE - 2021 -
Habitual FODMAP Intake in Relation to Symptom Severity and Pattern in Patients with Irritable Bowel
Syndrome
Sanna Nybacka, Stine Störsrud, Helen Lindqvist, Hans Törnblom, Magnus Simrén, Anna Winkvist
Nutrients - 2021 -
Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and
Omnivores
Helen Lindqvist, Millie Rådjursöga, Terese Torstensson, Linda Jansson, Lars Ellegård, Anna Winkvist
Journal of Nutrition - 2021 -
Diet intervention improves cardiovascular profile in patients with rheumatoid arthritis: results from the randomized controlled cross-over trial
ADIRA.
Erik Hulander, Linnea Bärebring, Anna Turesson Wadell, Inger Gjertsson, Philip C Calder, Anna Winkvist, Helen Lindqvist
Nutrition journal - 2021 -
Anti-inflammatory Diet In Rheumatoid Arthritis (ADIRA) - a randomized, controlled crossover trial indicating effects on disease
activity
Anna K. E. Vadell, Linnea Bärebring, Erik Hulander, Inger Gjertsson, Helen Lindqvist, Anna Winkvist
American Journal of Clinical Nutrition - 2020 -
Do Interventions with Diet or Dietary Supplements Reduce the Disease Activity Score in Rheumatoid Arthritis? A Systematic Review of Randomized Controlled
Trials.
Josefine Nelson, Helen Sjöblom, Inger Gjertsson, Stine M Ulven, Helen Lindqvist, Linnea Bärebring
Nutrients - 2020 -
Distinguishing vegan-, vegetarian-, and omnivorous diets by hair isotopic
analysis.
Lars Ellegård, Torgny Alstad, Tobias Rütting, Petra Hammarström Johansson, Helen Lindqvist, Anna Winkvist
Clinical nutrition - 2019 -
Serum metabolite profiles of habitual diet: evaluation by 1H-nuclear magnetic resonance
analysis
Helen Lindqvist, Millie Rådjursöga, Daniel Malmodin, Anna Winkvist, L. Ellegard
American Journal of Clinical Nutrition - 2019 -
The 1H NMR serum metabolomics response to a two meal challenge: a cross-over dietary intervention study in healthy human
volunteers.
Millie Rådjursöga, Helen Lindqvist, Anders Pedersen, B Göran Karlsson, Daniel Malmodin, Carl Brunius, Lars Ellegård, Anna Winkvist
Nutrition journal - 2019 -
Dietary Habits of Women with Rheumatoid Arthritis Differ from that of Women without the Disease: Results from a Population-Based
Study.
K Nypelius Standley, Inger Gjertsson, Anna Winkvist, Helen Lindqvist
J Rheum Dis Treat J - 2019 -
Influence of blue mussel (Mytilus edulis) intake on fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in women with rheumatoid
arthritis
Helen Lindqvist, Inger Gjertsson, Sofia E M Andersson, P. C. Calder, Linnea Bärebring
Prostaglandins Leukotrienes and Essential Fatty Acids - 2019 -
A randomized controlled cross-over trial investigating the effect of anti-inflammatory diet on disease activity and quality of life in rheumatoid arthritis: the Anti-inflammatory Diet In Rheumatoid Arthritis (ADIRA) study
protocol
Anna Winkvist, Linnea Bärebring, Inger Gjertsson, Lars Ellegård, Helen Lindqvist
Nutrition Journal - 2018 -
Influence of Blue Mussel (Mytilus edulis) Intake on Disease Activity in Female Patients with Rheumatoid Arthritis: The MIRA Randomized Cross-Over Dietary
Intervention.
Helen Lindqvist, Inger Gjertsson, Tove Eneljung, Anna Winkvist
Nutrients - 2018 -
Poor dietary quality is associated with increased inflammation in Swedish patients with rheumatoid
arthritis
Linnea Bärebring, Anna Winkvist, Inger Gjertsson, Helen Lindqvist
Nutrients - 2018 -
Nutritional metabolomics: Postprandial response of meals relating to vegan, lacto-ovo vegetarian, and omnivore
diets
Millie Rådjursöga, Helen Lindqvist, Anders Pedersen, B Göran Karlsson, Daniel Malmodin, Lars Ellegård, Anna Winkvist
Nutrients - 2018 -
Metabolic profiles from two different breakfast meals characterized by H-1 NMR-based
metabolomics
Millie Rådjursöga, B Göran Karlsson, Helen Lindqvist, Anders Pedersen, Cecilia Persson, R. C. Pinto, Lars Ellegård, Anna Winkvist
Food Chemistry - 2017 -
Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and
women
A. Vincent, O. I. Savolainen, P. Sen, N. G. Carlsson, A. Almgren, Helen Lindqvist, M. V. Lind, I. Undeland, A. S. Sandberg, A. B. Ross
Molecular Nutrition & Food Research - 2017 -
Efficacy of fish intake on vitamin D status: a meta-analysis of randomized controlled
trials
U. Lehmann, H. R. Gjessing, F. Hirche, A. Mueller-Belecke, O. A. Gudbrandsen, P. M. Ueland, G. Mellgren, L. Lauritzen, Helen Lindqvist, A. L. Hansen, A. T. Erkkila, G. K. Pot, G. I. Stangl, J. Dierkes
American Journal of Clinical Nutrition - 2015 -
Vitamin B12 as a potential compliance marker for fish
intake
Nathalie Scheers, Helen Lindqvist, Anna Maria Langkilde, Ingrid Undeland, Ann-Sofie Sandberg
European Journal of Nutrition - 2014 -
Herring (Clupea harengus) intake influences lipoproteins but not inflammatory and oxidation markers in overweight
men
Helen Lindqvist, Anna Maria Langkilde, Ingrid Undeland, Ann-Sofie Sandberg
British Journal of Nutrition - 2009 -
Plasma phospholipid EPA and DHA in relation to atherosclerosis in 61-year-old
men
Helen Lindqvist, Ann-Sofie Sandberg, Björn Fagerberg, Johannes Hulthe
Atherosclerosis - 2009 -
Influence of herring (Clupea harengus) and herring fractions on metabolic status in rats fed a high energy
diet.
Helen Lindqvist, Ann-Sofie Sandberg, Ingrid Undeland, Elisabet Stener-Victorin, Britt-Mari Larsson, Thippeswamy Sannaveerappa, Malin Lönn, Agneta Holmäng
Acta physiologica (Oxford, England) - 2009 -
Seafood and health-the full
story
Ingrid Undeland, Helen Lindqvist, Yun Chen, Eva Falch, Alfons Ramel, Marie Cooper, Asbjörn Gildberg, Joop Luten, Even Stenberg, Henrik Hauch Nielsen, Edel Elvevoll
Marine Functional Foods - 2009 -
Protein profiling of low-density lipoprotein from obese
subjects
H. Karlsson, H. Mortstedt, Helen Lindqvist, C. Tagesson, M. Lindahl
Proteomics Clinical Applications - 2009 -
Influence of Herring (Clupea harengus) Intake on Risk Factors for Cardiovascular
Disease
Helen Lindqvist
2008 -
Herring (Clupea harengus) supplemented diet influence risk factors for CVD in overweight
subjects
Helen Lindqvist, Anna-Maria Langkilde, Ingrid Undeland, Therese Rådendal, Ann-Sofie Sandberg
European Journal of Clinical Nutrition - 2007 -
Characterization of Apolipoprotein M Isoforms in Low-Density
Lipoprotein
Helen Karlsson, Helen Lindqvist, Christer Tagesson, Mats Lindahl
Journal of Proteome Research - 2006