University of Gothenburg
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John Fletcher

Professor

Department of Chemistry & Molecular Biology
Telephone
+46 31-786 91 05
+46 766-22 91 05
Mail
john.fletcher@chem.gu.se
Visiting address
Medicinaregatan 7 B
413 90 Göteborg
Room number
7454
Postal address
Box 462
405 30 Göteborg

About John Fletcher

My groups research is focused on the development and application of imaging mass spectrometry for biological analysis. Mass spectrometry provides molecular specific chemical information without the need to incorporate exogenous labels. When used in an imaging modality this chemical precision is combined with precise spatial distribution. Secondary ion mass spectrometry (SIMS) uses a focused ion beam to probe the surface of a sample and the nature of the ion beam fired at the sample can ultimately determine what chemical species are detected in the mass spectrometer. As there is a constant demand for more signal at higher resolution and so ion beam development is an active area of research particularly using new gas cluster ion beam technology. For biological sample analysis ensuring that the data generated is representative of the "live" sample means that methods to prepare and analyse biological specimen in the vacuum environment required for imaging SIMS are critical. Combining the new ion beams with optimal sample preperation provides a route to identifying lipidomic changes on a sub-cellular scale, potentially in 3D, in order elucidate the underlying chemical processes involved in disease progression and treatment.

Current group members

Alfred Fransson

Simon Uzoni

Teaching and Departmental Responsibilities

KEM070 - Basic Analytical Chemistry

KEM082 - Advanced Bioanalytical Chemistry

KEA310 - Introduction to Analytical Chemistry

GOOGLE SCHOLAR