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Kristina Eriksson
Professor
Department of Rheumatology and Inflammation ResearchAbout Kristina Eriksson
Kristina Eriksson was born in Stockholm and graduated from Gothenburg University in 1989. She defended her thesis "HIV and mucosal immunity: Implications for vaccine development" in 1995 and then spent the next two years as a post-doc at Cambridge University. She became Associate Professor of Immunology in 2000 and was in 2006 awarded a Research Fellowship in Microbial Pathogenesis by the Swedish Research Council.
From April 1, 2009, she is professor of viral immune pathology at the Department of Rheumatology and Inflammation Research, Institute of Medicine.
Research
My research project deals with the interplay between virus and the host´s immune system during infection. My working hypothesis is that herpesviruses and their human host have co-evolved during evolution leading to a symbiosis between the virus and the host’s immune system.
The aim of my research is therefore to investigate the interactions between virus and host during chronic herpesvirus infection. In addition, I am interested in identifying novel anti-viral treatments. For these purposes, I study:
- The neuroimmune regulation of herpes simplex virus type 2 (HSV-2) infection, with special emphasis on the establishment of viral latency in the CNS. These studies are performed in mice, and involve the characterization of immune responses within the CNS and its role in controlling viral replication.
- Host genetic factors that contribute to HSV-2 disease development. These studies are performed in HSV-2 infected humans who do, or do not, display symptoms of disease.
- If herpesvirus infections can influence the development of allergy in young children. The relationship between herpesvirus infections and allergic sensitization is characterized in 18 month old children and we concomitantly assess the impact of these viruses on the developing immune system. An animal model has been established to further these studies on a mechanistic lever.
- The use of endogenous and synthetic substances as anti-viral agents. The main goal is to be able to eradicate an already established chronic viral infection.
-
Fas/FasL-Mediated Apoptosis and Inflammation Contribute to Recovery from HSV-2-Mediated Spinal Cord
Infection
Malgorzata Krzyzowska, Magdalena Patrycy, Marcin Chodkowski, Martyna Janicka, Andrzej Kowalczyk, Katarzyna Skulska, Karolina Thörn, Kristina Eriksson
VIRUSES-BASEL - 2024 -
Human Antibodies against Herpes Simplex Virus 2 Glycoprotein G Do Not Neutralize but Mediate Antibody-Dependent Cellular
Cytotoxicity
Jan-Åke Liljeqvist, Karin Önnheim, Petra Tunbäck, Kristina Eriksson, Staffan Görander, Malin Bäckström, Tomas Bergström
ANTIBODIES - 2024 -
The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from
COVID-19.
Viktoria Hennings, Karolina Thörn, Sofie Albinsson, Christine Lingblom, Kerstin Andersson, Christer Andersson, Katarina Järbur, Rille Pullerits, Manja Idorn, Sören R Paludan, Kristina Eriksson, Christine Wennerås
European journal of immunology - 2022 -
Tofacitinib treatment in primary herpes simplex encephalitis interferes with anti-viral
response.
Malgorzata Krzyzowska, Anders Jarneborn, Karolina Thörn, Kristina Eriksson, Tao Jin
The Journal of infectious diseases - 2022 -
Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with
plasmapheresis
Andri Lemarquis, Tessa Campbell, Maribel Aranda-Guillén, Viktoria Hennings, Petter Brodin, Olle Kämpe, Kaj Blennow, Henrik Zetterberg, Christine Wennerås, Kristina Eriksson, Nils Landegren, Yenan Bryceson, Stefan Berg, Olov Ekwall
Journal of Allergy and Clinical Immunology - 2021 -
Fas/FasL Contributes to HSV-1 Brain Infection and
Neuroinflammation
Malgorzata Krzyzowska, A. Kowalczyk, K. Skulska, Karolina Thörn, Kristina Eriksson
Frontiers in Immunology - 2021 -
Cerebrospinal fluid biomarkers of brain injury, inflammation and synaptic autoimmunity predict long-term neurocognitive outcome in herpes simplex
encephalitis.
Gabriel Westman, Elisabeth Aurelius, Clas Ahlm, Kaj Blennow, Kristina Eriksson, Lisa Lind, Silvia Schliamser, Fredrik Sund, Henrik Zetterberg, Marie Studahl
Clinical microbiology and infection - 2021 -
CD8(+) T cells in the central nervous system of mice with herpes simplex infection are highly activated and express high levels of CCR5 and
CXCR3
Liza Lind, Alexandra Svensson, Karolina Thörn, Malgorzata Krzyzowska, Kristina Eriksson
Journal of Neurovirology - 2021 -
Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in
humans
A. S. Hait, D. Olagnier, V. Sancho-Shimizu, K. A. Skipper, M. Helleberg, S. M. Larsen, C. Bodda, L. I. Moldovan, F. H. Ren, N. S. B. Andersen, M. M. Thomsen, M. R. Freytag, S. Darmalinggam, I. Parkes, D. D. Kadekar, S. H. Rahbek, D. van der Horst, L. S. Kristensen, Kristina Eriksson, J. Kjems, S. Mostowy, M. Christiansen, J. G. Mikkelsen, C. T. Brandt, Sören R Paludan, T. H. Mogensen
Science Immunology - 2020 -
Prevalence of viral sexually transmitted infections and HPV high-risk genotypes in women in rural communities in the Department of la Paz,
Bolivia
Marianela Patzi Churqui, Katty Terrazas-Aranda, Jan-Åke Liljeqvist, Magnus Lindh, Kristina Eriksson
BMC Infectious Diseases - 2020 -
Chemokines and matrix metalloproteinases in cerebrospinal fluid of patients with central nervous system complications caused by varicella-zoster
virus
Liza Lind, Kristina Eriksson, Anna Grahn
Journal of Neuroinflammation - 2019 -
HSV-2 Cellular Programming Enables Productive HIV Infection in Dendritic
Cells
E. Crisci, C. Svanberg, R. Ellegard, M. Khalid, J. Hellblom, K. Okuyama, P. Bhattacharya, S. Nystrom, E. M. Shankar, Kristina Eriksson, M. Larsson
Frontiers in Immunology - 2019 -
Antiviral activity of tannic acid modified silver nanoparticles: Potential to activate immune response in herpes
genitalis
P. Orłowski, A. Kowalczyk, E. Tomaszewska, K. Ranoszek-Soliwoda, A. Węgrzyn, J. Grzesiak, G. Celichowski, J. Grobelny, Kristina Eriksson, M. Krzyzowska
Viruses - 2018 -
Extracts of Equisetum giganteum L and Copaifera reticulate Ducke show strong antiviral activity against the sexually transmitted pathogen herpes simplex virus type
2
Marianela Patzi Churqui, Liza Lind, Karolina Thörn, Alexandra Svensson, O. Savolainen, K. T. Aranda, Kristina Eriksson
Journal of Ethnopharmacology - 2018 -
Maturation-dependent expression of AIM2 in human
B-cells
Alexandra Svensson, Marianela Patzi Churqui, Kerstin Schlüter, Liza Lind, Kristina Eriksson
Plos One - 2017 -
Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β
Expression.
Kristina Eriksson, Alexandra Svensson, Alon S Hait, Kerstin Schlüter, Petra Tunbäck, Inger Nordström, Leonid Padyukov, Jan-Åke Liljeqvist, Trine H Mogensen, Søren R Paludan
Journal of immunology (Baltimore, Md. : 1950) - 2017 -
CXCL11 production in cerebrospinal fluid distinguishes herpes simplex meningitis from herpes simplex
encephalitis
Liza Lind, Marie Studahl, Linn Persson Berg, Kristina Eriksson
Journal of Neuroinflammation - 2017 -
Complement Opsonization Promotes Herpes Simplex Virus 2 Infection of Human Dendritic
Cells
E. Crisci, R. Ellegard, S. Nystrom, E. Rondahl, L. Serrander, Tomas Bergström, C. Sjowall, Kristina Eriksson, M. Larsson
Journal of Virology - 2016 -
An innate antiviral pathway acting before interferons at epithelial
surfaces
M. B. Iversen, L. S. Reinert, M. K. Thomsen, I. Bagdonaite, R. Nandakumar, N. Cheshenko, T. Prabakaran, S. Y. Vakhrushev, M. Krzyzowska, S. K. Kratholm, F. Ruiz-Perez, S. V. Petersen, S. Goriely, B. M. Bibby, Kristina Eriksson, J. Rulandl, A. R. Thomsen, B. C. Herold, H. H. Wandall, S. Frischel, C. K. Hom, S. R. Paludan
Nature Immunology - 2016 -
HSV-2 regulates monocyte inflammatory response via the Fas/FasL
pathway.
Malgorzata Krzyzowska, Piotr Baska, Piotr Orlowski, Robert Zdanowski, Anna Winnicka, Kristina Eriksson, Wanda Stankiewicz
PloS one - 2013 -
Synthetic analogues of bovine bactenecin dodecapeptide reduce herpes simplex virus type 2 infectivity in
mice.
Andrey Shestakov, Håvard Jenssen, Robert E W Hancock, Inger Nordström, Kristina Eriksson
Antiviral research - 2013 -
TLR3 impairment in human
newborns.
Lucija Slavica, Inger Nordström, Merja Nurkkala Karlsson, Hadi Valadi, Marian Kacerovsky, Bo Jacobsson, Kristina Eriksson
Journal of leukocyte biology - 2013 -
Enveloped virus but not bacteria block IL-13 responses in human cord blood T cells in
vitro.
Alexandra Svensson, Inger Nordström, Anna Rudin, Tomas Bergström, Kristina Eriksson
Scandinavian journal of immunology - 2012 -
Lactoferricin but not lactoferrin inhibit herpes simplex virus type 2 infection in
mice.
Andrey Shestakov, Håvard Jenssen, Inger Nordström, Kristina Eriksson
Antiviral research - 2012 -
STAT4 Regulates Antiviral Gamma Interferon Responses and Recurrent Disease during Herpes Simplex Virus 2
Infection.
Alexandra Svensson, Petra Tunbäck, Inger Nordström, Andrey Shestakov, Leonid Padyukov, Kristina Eriksson
Journal of virology - 2012 -
Polymorphisms in Toll-like receptor 3 confer natural resistance to human herpes simplex virus type 2
infection.
Alexandra Svensson, Petra Tunbäck, Inger Nordström, Leonid Padyukov, Kristina Eriksson
The Journal of general virology - 2012 -
Indoleamine 2,3-dioxygenase Expression and Functional Activity in Dendritic Cells Exposed to Cholera
Toxin
Lucija Slavica, Merja Nurkkala Karlsson, Tanya (De L.) Karlson, Madeleine Ingelsten, Jenny Nyström, Kristina Eriksson
Scandinavian Journal of Immunology - 2012 -
HHV-6B Induces IFN-Lambda1 Responses in Cord Plasmacytoid Dendritic Cells through
TLR9
Inger Nordström, Kristina Eriksson
Plos One - 2012 -
Role of Fas/FasL in regulation of inflammation in vaginal tissue during HSV-2
infection.
M Krzyzowska, Andrey Shestakov, Kristina Eriksson, F Chiodi
Cell death & disease - 2011 -
Characterization of natural killer cell phenotype and function during recurrent human HSV-2
infection.
Niklas K Björkström, Alexandra Svensson, Karl-Johan Malmberg, Kristina Eriksson, Hans-Gustaf Ljunggren
PloS one - 2011 -
Conjugation of HPV16 E7 to cholera toxin enhances the HPV-specific T-cell recall responses to pulsed dendritic cells in vitro in women with cervical
dysplasia.
Merja Nurkkala, Lotta Wassén, Inger Nordström, Inger Gustavsson, Lucija Slavica, Agnetha Josefsson, Kristina Eriksson
Vaccine - 2010 -
Inhibition of γ-secretase cleavage in the notch signaling pathway blocks HSV-2-induced type I and type II interferon
production.
Alexandra Svensson, Emely Jäkärä, Andrey Shestakov, Kristina Eriksson
Viral immunology - 2010 -
Exposure to Human Herpes Virus type 6 protects against allergic asthma in
mice
Alexandra Svensson, Nina Almqvist, Annie George-Chandy, Inger Nordström, Kristina Eriksson
Journal of Allergy & Therapy - 2010 -
Infection of infants with human herpesvirus type 6 may be associated with reduced allergic sensitization and T-helper type 2
development.
Inger Nordström, Anna Rudin, Ingegerd Adlerberth, Agnes E Wold, Robert Saalman, Bill Hesselmar, Nils Åberg, Jan-Åke Liljeqvist, Kristina Eriksson
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 2010 -
Lipopolysaccharide Sensitizes Neonatal Hypoxic-Ischemic Brain Injury in a MyD88-Dependent
Manner
Xiaoyang Wang, Linnea Stridh, Wenli Li, J. Dean, A. Elmgren, L. Gan, Kristina Eriksson, Henrik Hagberg, Carina Mallard
Journal of Immunology - 2009 -
Svårt att avgöra när ögonsjukdom leder till funktionshinder. Patientskattning av synfunktionen bra stöd för läkarens
bedömning.
Kristina Eriksson, Johan Sjöstrand, Ulla Kroksmark
Läkartidningen - 2008 -
A 3'-untranslated region polymorphism in the TBX21 gene encoding T-bet is a risk factor for genital herpes simplex virus type 2 infection in
humans.
Alexandra Svensson, Ann-Marie H Bergin, Gun-Britt Löwhagen, Petra Tunbäck, Lars Bellner, Leonid Padyukov, Kristina Eriksson
The Journal of general virology - 2008 -
Th17 development and autoimmune arthritis in the absence of reactive oxygen
species.
Annie George-Chandy, Inger Nordström, Erik Nygren, Ing-Marie Jonsson, Jorge Postigo, Vincent Collins, Kristina Eriksson
European journal of immunology - 2008 -
Raised intrathecal levels of APRIL and BAFF in patients with systemic lupus erythematosus: relationship to neuropsychiatric
symptoms.
Annie George-Chandy, Estelle Trysberg, Kristina Eriksson
Arthritis research & therapy - 2008 -
Role of IFN-alpha/beta signaling in the prevention of genital herpes virus type 2
infection.
Alexandra Svensson, Lars Bellner, Mattias Magnusson, Kristina Eriksson
Journal of reproductive immunology - 2007 -
Ability of monocyte-derived dendritic cells to secrete oxygen radicals in response to formyl peptide receptor family agonists compared to that of myeloid and plasmacytoid dendritic
cells
Anna Karlsson, Erik Nygren, Jenny Karlsson, Inger Nordström, Claes Dahlgren, Kristina Eriksson
Clin Vaccine Immunol - 2007 -
A Monocyte-Specific Peptide from Herpes Simplex Virus Type 2 Glycoprotein G Activates the NADPH-Oxidase but Not Chemotaxis through a G-Protein-Coupled Receptor Distinct from the Members of the Formyl Peptide Receptor
Family.
Lars Bellner, Jennie Karlsson, Huamei Fu, François Boulay, Claes Dahlgren, Kristina Eriksson, Anna Karlsson
Journal of immunology (Baltimore, Md. : 1950) - 2007 -
Therapeutic dendritic cell vaccination with Ag coupled to cholera toxin in combination with intratumoural CpG injection leads to complete tumour eradication in mice bearing HPV 16 expressing
tumours.
Annie George Chandy, Merja Nurkkala, Agnetha Josefsson, Kristina Eriksson
Vaccine - 2007 -
MHC expression and chemokine production in the murine vagina following intra-vaginal administration of ligands to toll-like receptors 3, 7 and
9
Merja Nurkkala, Inger Nordström, Esbjörn Telemo, Kristina Eriksson
J Reprod Immunol - 2007 -
Longterm visual prognosis in Usher syndrome types 1 and
2
André M. Sadeghi, Kristina Eriksson, William J. Kimberling, Anders Sjöström, Claes Möller
Acta Ophthalmologica - 2006 -
Disruption of interleukin-18, but not interleukin-1, increases vulnerability to preterm delivery and fetal mortality after intrauterine
inflammation
Xiaoyang Wang, Henrik Hagberg, Carina Mallard, Changlian Zhu, Maj Hedtjärn, Carl Fredrik Tiger, Kristina Eriksson, Åsa Rosen, Bo Jacobsson
Am J Pathol - 2006 -
Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in
vivo.
Nina Ank, Hans West, Christina Bartholdy, Kristina Eriksson, Allan R Thomsen, Søren R Paludan
Journal of virology - 2006 -
Neurokinin 1 receptor signaling affects the local innate immune defense against genital herpes virus
infection.
Alexandra Svensson, Joanna Kaim, Carina Mallard, Annika Olsson, Ernst Brodin, Tomas Hökfelt, Kristina Eriksson
Journal of immunology (Baltimore, Md. : 1950) - 2005 -
Protective immunity to genital herpes simplex [correction of simpex] virus type 2 infection is mediated by
T-bet.
Alexandra Svensson, Inger Nordström, Jia-Bin Sun, Kristina Eriksson
Journal of immunology (Baltimore, Md. : 1950) - 2005 -
Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG
DNA
Jan Holmgren, Jenni Adamsson, F. Anjuere, J. Clemens, C. Czerkinsky, Kristina Eriksson, Carl-Fredrik Flach, Annie George-Chandy, Ali M Harandi, Michael Lebens, T. Lehner, Marianne Lindblad, Erik Nygren, Sukanya Raghavan, Joaquin Sanchez, M. Stanford, Jia-Bin Sun, Ann-Mari Svennerholm, Sara Tengvall
Immunol Lett - 2005 -
A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell
functions
Lars Bellner, Fredrik Bergh Thorén, Erik Nygren, Jan-Åke Liljeqvist, Anna Karlsson, Kristina Eriksson
J Immunol - 2005 -
Characterization of T-cell reactive epitopes in glycoprotein G of herpes simplex virus type 2 using synthetic
peptides.
Lars Bellner, Gun-Britt Löwhagen, Petra Tunbäck, Inger Nordström, Jan-Åke Liljeqvist, Kristina Eriksson
Archives of virology - 2005 -
Role of substance P in the local immune defence against genital herpes
infection
A Svensson, Joanna Kaim, Carina Mallard, A Olsson, E Brodin, T Hokfelt, Kristina Eriksson
J Immunolgy - 2005 -
CD8+ T-cells suppress antigen-specific and allogeneic CD4+ T-cell responses to herpes simplex virus type 2-infected human dendritic
cells.
Inger Nordström, Merja Nurkkala, Vincent Collins, Kristina Eriksson
Viral immunology - 2005 -
The arthritogenic and immunostimulatory properties of phosphorothioate oligodeoxynucleotides rely on synergy between the activities of the nuclease-resistant backbone and CpG
motifs
Jan Bjersing, Kristina Eriksson, Andrej Tarkowski, Vincent Collins
Inflammation - 2004 -
Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of dendritic
cells.
Jia-Bin Sun, Kristina Eriksson, Bin-Ling Li, Marianne Lindblad, Josef Azem, Jan Holmgren
Clinical immunology (Orlando, Fla.) - 2004 -
Coupling of antigen to cholera toxin for dendritic cell vaccination promotes the induction of MHC class I-restricted cytotoxic T cells and the rejection of a cognate antigen-expressing model
tumor.
Kristina Eriksson, Jia-Bin Sun, Inger Nordström, Margareta Fredriksson, Marianne Lindblad, Bin-Ling Li, Jan Holmgren
European journal of immunology - 2004 -
Mannan-binding lectin modulates the response to HSV-2
infection.
M Gadjeva, S R Paludan, S Thiel, V Slavov, M Ruseva, Kristina Eriksson, Gun-Britt Löwhagen, L Shi, K Takahashi, A Ezekowitz, J C Jensenius
Clinical and experimental immunology - 2004 -
Interactions of Haemophilus ducreyi and purified cytolethal distending toxin with human monocyte-derived dendritic cells, macrophages and CD4+ T
cells.
Tingting Xu, Annika Lundqvist, Hinda J Ahmed, Kristina Eriksson, Yonghong Yang, Teresa Lagergård
Microbes and infection / Institut Pasteur - 2004 -
Increased mortality in COPD among construction workers exposed to inorganic
dust
IA Bergdahl, Kjell Torén, Kristina Eriksson, U Hedlund, T Nilsson, R Flodin, B Järvholm
Eur Respir J - 2004 -
CD4(+) T-cell responses to herpes simplex virus type 2 (HSV-2) glycoprotein G are type specific and differ in symptomatic and asymptomatic HSV-2-infected
individuals
Kristina Eriksson, Lars Bellner, Staffan Görander, Gun-Britt Löwhagen, Petra Tunbäck, K. Rydberg, Jan-Åke Liljeqvist
J Gen Virol - 2004 -
The nontoxic tripeptide glycyl-prolyl-glycine amide inhibits the replication of human immunodeficiency virus type
1.
J Su, Elin Andersson, Peter Horal, M H Naghavi, A Palm, Y P Wu, Kristina Eriksson, M Jansson, H Wigzell, Bo Svennerholm, A Vahlne
Journal of human virology - 2001