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Fredrik Bergh Thorén
Professor
Department of Medical Biochemistry and Cell biologyAbout Fredrik Bergh Thorén
Fredrik Bergh Thorén is Professor of Medical Cell Biology at Sahlgrenska Cancer Center and the Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine at the University of Gothenburg. He obtained his PhD in 2007 on studies of cell death pathways in oxidant-exposed lymphocytes. Between 2008 and 2009, he performed postdoctoral studies on the innate crosstalk between NK cells and neutrophils in the labs of Prof Alessandro Moretta and Prof Lorenzo Moretta at the University of Genoa in Italy. Upon his return to Sweden, he established his own lab with a focus on translational studies of NK cell interactions with myeloid cells in leukemia and inflammation (More info at thorenlab.com).
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Single-cell proteo-transcriptomic profiling reveals altered characteristics of stem and progenitor cells in patients receiving cytoreductive hydroxyurea in early-phase chronic myeloid
leukemia.
Hana Komic, Malin S. Nilsson, Lovisa Wennström, Tagore Sanketh Bandaru, Pekka Jaako, Kristoffer Hellstrand, Fredrik Bergh Thorén, Anna Martner
Haematologica - 2024 -
Single-cell sequencing unveils extensive intratumoral heterogeneity of cancer/testis antigen expression in melanoma and lung
cancer
Sofie Traynor, Mie K. Jakobsen, Tina M. Green, Hana Komic, Yaseelan Palarasah, Christina B. Pedersen, Henrik J. Ditzel, Fredrik Bergh Thorén, Per Guldberg, Morten F. Gjerstorff
JOURNAL FOR IMMUNOTHERAPY OF CANCER - 2024 -
Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell
cytotoxicity
Linnea Kristenson, Chiara Badami, Angelica Ljungberg, Erna Islamagic, Yarong Tian, Guojiang Xie, Brwa Ali Hussein, Silvia Pesce, Ka-Wei Tang, Fredrik Bergh Thorén
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA - 2024 -
NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK
cells
Brwa Ali Hussein, Linnea Kristenson, Silvia Pesce, Anne Wöhr, Yarong Tian, Alexander Hallner, Mats Brune, Kristoffer Hellstrand, Ka-Wei Tang, Elin Bernson, Fredrik Bergh Thorén
JOURNAL FOR IMMUNOTHERAPY OF CANCER - 2023 -
ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4
expression
Tzu-Po Chuang, Wei-Yun Lai, Jonatan L. Gabre, Dan E. Lind, Ganesh Umapathy, Abdulmalik Bokhari, Bengt Bergman, Linnea Kristenson, Fredrik Bergh Thorén, Anh Le, Robert C. Doebele, Jimmy Van den Eynden, Ruth H. Palmer, Bengt Hallberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA - 2023 -
Impact of IL-1β and the IL-1R antagonist on relapse risk and survival in AML patients undergoing immunotherapy for remission
maintenance.
Hanna Grauers Wiktorin, Ebru Aydin, Karin Christenson, Nuttida Issdisai, Fredrik Bergh Thorén, Kristoffer Hellstrand, Anna Martner
Oncoimmunology - 2021 -
Idelalisib Rescues Natural Killer Cells from Monocyte-Induced Immunosuppression by Inhibiting NOX2-Derived Reactive Oxygen
Species.
Aliasghar Akhiani, Alexander Hallner, Roberta Kiffin, Ebru Aydin, Olle Werlenius, Johan Aurelius, Anna Martner, Fredrik Bergh Thorén, Kristoffer Hellstrand
Cancer immunology research - 2020 -
Complete remission after the first cycle of induction chemotherapy determines the clinical efficacy of relapse-preventive immunotherapy in acute myeloid
leukaemia.
Malin S. Nilsson, Alexander Hallner, Mats Brune, Staffan Nilsson, Fredrik Bergh Thorén, Anna Martner, Kristoffer Hellstrand
British journal of haematology - 2020 -
miRNAs in NK Cell-Based Immune Responses and Cancer
Immunotherapy
S. Pesce, M. Greppi, E. Ferretti, V. Obino, S. Carlomagno, M. Rutigliani, Fredrik Bergh Thorén, S. Sivori, P. Castagnola, S. Candiani, E. Marcenaro
Frontiers in Cell and Developmental Biology - 2020 -
Immunotherapy with HDC/IL-2 may be clinically efficacious in acute myeloid leukemia of normal
karyotype
Malin S. Nilsson, Alexander Hallner, Mats Brune, Staffan Nilsson, Fredrik Bergh Thorén, Anna Martner, Kristoffer Hellstrand
Human Vaccines & Immunotherapeutics - 2020 -
Downregulation of HLA Class I Renders Inflammatory Neutrophils More Susceptible to NK Cell-Induced
Apoptosis
Elin Bernson, Karin Christenson, Silvia Pesce, Malin Pasanen, E. Marcenaro, S. Sivori, Fredrik Bergh Thorén
Frontiers in Immunology - 2019 -
Anthracycline-based consolidation may determine outcome of post-consolidation immunotherapy in
AML
Johan Aurelius, Lars Möllgård, Roberta Kiffin, Frida Ewald Sander, Staffan Nilsson, Fredrik Bergh Thorén, Kristoffer Hellstrand, Anna Martner
Leukemia & Lymphoma - 2019 -
The HLA-B-21 dimorphism impacts on NK cell education and clinical outcome of immunotherapy in acute myeloid
leukemia
Alexander Hallner, Elin Bernson, Brwa Ali Hussein, Frida Ewald Sander, Mats Brune, Johan Aurelius, Anna Martner, Kristoffer Hellstrand, Fredrik Bergh Thorén
Blood - 2019 -
Anti-Leukemic Properties of Histamine in Monocytic Leukemia: The Role of
NOX2
Roberta Kiffin, Hanna Grauers Wiktorin, Malin S. Nilsson, Johan Aurelius, Ebru Aydin, Brianna Lenox, Jonas A Nilsson, Anders Ståhlberg, Fredrik Bergh Thorén, Kristoffer Hellstrand, Anna Martner
Frontiers in Oncology - 2018 -
Cytomegalovirus Serostatus Affects Autoreactive NK Cells and Outcomes of IL2-Based Immunotherapy in Acute Myeloid
Leukemia
Elin Bernson, Alexander Hallner, Frida Ewald Sander, Malin Nicklasson, Malin S. Nilsson, Karin Christenson, Ebru Aydin, Jan-Åke Liljeqvist, Mats Brune, R. Foa, Johan Aurelius, Anna Martner, Kristoffer Hellstrand, Fredrik Bergh Thorén
Cancer Immunology Research - 2018 -
Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem
Cells.
Anna Wenger, Katja Werlenius, Alexander Hallner, Fredrik Bergh Thorén, Dan Farahmand, Magnus Tisell, Anja Smits, Bertil Rydenhag, Asgeir Store Jakola, Helena Carén
Neoplasia - 2018 -
Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid
leukemia
Elin Bernson, Alexander Hallner, Frida Ewald Sander, O. Wilsson, Olle Werlenius, Anna Rydström, Roberta Kiffin, Mats Brune, R. Foa, Johan Aurelius, Anna Martner, Kristoffer Hellstrand, Fredrik Bergh Thorén
Leukemia - 2017 -
Dynamics of myeloid cell populations during relapse-preventive immunotherapy in acute myeloid
leukemia
Anna Rydström, Alexander Hallner, Johan Aurelius, Frida Ewald Sander, Elin Bernson, Roberta Kiffin, Fredrik Bergh Thorén, Kristoffer Hellstrand, Anna Martner
Journal of Leukocyte Biology - 2017 -
Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive
immunotherapy
Frida Ewald Sander, Stathis Kotsakis, Anna Rydström, Johan Aurelius, Rebecca E Riise, Charlotta Movitz, Elin Bernson, Roberta Kiffin, Anders Ståhlberg, Mats Brune, R. Foa, Kristoffer Hellstrand, Fredrik Bergh Thorén, Anna Martner
Cancer Immunology Immunotherapy - 2017 -
NOX2-dependent immunosuppression in chronic myelomonocytic
leukemia
Johan Aurelius, Alexander Hallner, Olle Werlenius, Rebecca E Riise, L. Mollgard, M. Brune, M. Hansson, Anna Martner, Fredrik Bergh Thorén, Kristoffer Hellstrand
Journal of Leukocyte Biology - 2017 -
The Innate Immune Cross Talk between NK Cells and Eosinophils Is Regulated by the Interaction of Natural Cytotoxicity Receptors with Eosinophil Surface
Ligands
S. Pesce, Fredrik Bergh Thorén, C. Cantoni, C. Prato, L. Moretta, A. Moretta, E. Marcenaro
Frontiers in Immunology - 2017 -
Role of natural killer cell subsets and natural cytotoxicity receptors for the outcome of immunotherapy in acute myeloid
leukemia
Anna Martner, Anna Rydström, Rebecca E Riise, Johan Aurelius, H. Anderson, Mats Brune, R. Foa, Kristoffer Hellstrand, Fredrik Bergh Thorén
Oncoimmunology - 2016 -
Opposing effects of immunotherapy in melanoma using multisubtype interferon-alpha - can tumor immune escape after immunotherapy accelerate disease
progression?
Örjan Strannegård, Fredrik Bergh Thorén
Oncoimmunology - 2016 -
Reactive oxygen species induced by therapeutic CD20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary CLL
cells
Olle Werlenius, Johan Aurelius, Alexander Hallner, Aliasghar Akhiani, Maria Simpanen, Anna Martner, Per-Ola Andersson, Kristoffer Hellstrand, Fredrik Bergh Thorén
Oncotarget - 2016 -
Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid
leukemia
Frida Ewald Sander, Anna Rydström, Elin Bernson, Roberta Kiffin, Rebecca E Riise, Johan Aurelius, H. Anderson, Mats Brune, R. Foa, Kristoffer Hellstrand, Fredrik Bergh Thorén, Anna Martner
Oncotarget - 2016 -
Immunotherapy with histamine dihydrochloride and low-dose interleukin-2 favors sustained lymphocyte recovery in acute myeloid
leukemia.
Alexander Hallner, Johan Aurelius, Fredrik Bergh Thorén, Frida Ewald Sander, Mats Brune, Kristoffer Hellstrand, Anna Martner
European journal of haematology - 2015 -
NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission
maintenance.
Anna Martner, Anna Rydström, Rebecca E Riise, Johan Aurelius, Mats Brune, Robin Foà, Kristoffer Hellstrand, Fredrik Bergh Thorén
Oncotarget - 2015 -
TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell
Responses
Rebecca E Riise, Elin Bernson, Johan Aurelius, Anna Martner, S. Pesce, M. Della Chiesa, E. Marcenaro, Johan Bylund, Kristoffer Hellstrand, L. Moretta, A. Moretta, Fredrik Bergh Thorén
Journal of Immunology - 2015 -
Histamine Promotes the Development of Monocyte-Derived Dendritic Cells and Reduces Tumor Growth by Targeting the Myeloid NADPH
Oxidase
Anna Martner, Hanna Grauers Wiktorin, Brianna Lenox, Frida Ewald Sander, Ebru Aydin, Johan Aurelius, Fredrik Bergh Thorén, Anders Ståhlberg, Svante Hermodsson, Kristoffer Hellstrand
Journal of Immunology - 2015 -
CD20 antibodies induce production and release of reactive oxygen species by
neutrophils.
Olle Werlenius, Rebecca E Riise, Maria Simpanen, Johan Aurelius, Fredrik Bergh Thorén
Blood - 2014 -
Role of the ERK Pathway for Oxidant-Induced Parthanatos in Human
Lymphocytes
Aliasghar Akhiani, Olle Werlenius, Johan Aurelius, Charlotta Movitz, Anna Martner, Kristoffer Hellstrand, Fredrik Bergh Thorén
Plos One - 2014 -
Immunotherapeutic strategies for relapse control in acute myeloid
leukemia
Anna Martner, Fredrik Bergh Thorén, Johan Aurelius, Kristoffer Hellstrand
Blood Reviews - 2013 -
Late divergence of survival curves in cancer immunotherapy trials: interpretation and
implications
Fredrik Bergh Thorén, H. Anderson, Örjan Strannegård
Cancer Immunology Immunotherapy - 2013 -
A simple skin blister technique for the study of in vivo transmigration of human
leukocytes.
Lisa Davidsson, Lena Björkman, Karin Christenson, Mikael Alsterholm, Charlotta Movitz, Fredrik Bergh Thorén, Anna Karlsson, Amanda Welin, Johan Bylund
Journal of immunological methods - 2013 -
Chronic myeloid leukemic cells trigger poly(ADP-ribose) polymerase-dependent inactivation and cell death in
lymphocytes.
Johan Aurelius, Anna Martner, Rebecca E Riise, Ana Romero, Lars Palmqvist, Mats Brune, Kristoffer Hellstrand, Fredrik Bergh Thorén
Journal of leukocyte biology - 2013 -
Human NK Cells induce neutrophil apoptosis via an NKp46- and Fas-dependent
mechanism.
Fredrik Bergh Thorén, Rebecca E Riise, Jenny Ousbäck, Mariella Della Chiesa, Mikael Alsterholm, Emanuela Marcenaro, Silvia Pesce, Carola Prato, Claudia Cantoni, Johan Bylund, Lorenzo Moretta, Alessandro Moretta
Journal of immunology (Baltimore, Md. : 1950) - 2012 -
Remission maintenance in acute myeloid leukemia: impact of functional histamine H2 receptors expressed by leukemic
cells.
Johan Aurelius, Anna Martner, Mats Brune, Lars Palmqvist, Markus Hansson, Kristoffer Hellstrand, Fredrik Bergh Thorén
Haematologica - 2012 -
Analyzing cell death events in cultured
leukocytes.
Karin Christenson, Fredrik Bergh Thorén, Johan Bylund
Methods in molecular biology (Clifton, N.J.) - 2012 -
Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase/gp91(phox) expression and the PARP-1/PAR pathway of
apoptosis.
Johan Aurelius, Fredrik Bergh Thorén, Aliasghar Akhiani, Mats Brune, Lars Palmqvist, Markus Hansson, Kristoffer Hellstrand, Anna Martner
Blood - 2012 -
Redox Remodeling by Dendritic Cells Protects Antigen-Specific T Cells against Oxidative
Stress
Anna Martner, Johan Aurelius, Anna Rydström, Kristoffer Hellstrand, Fredrik Bergh Thorén
Journal of Immunology - 2011 -
Antitumor properties of histamine in
vivo.
Fredrik Bergh Thorén, Johan Aurelius, Anna Martner
Nature medicine - 2011 -
Adjuvant interferon: extended follow-up times
needed?
Fredrik Bergh Thorén, Örjan Strannegård
Lancet Oncol - 2011 -
Age-Related Efficacy of Immunotherapy with Histamine Dihydrochloride and Interleukin-2 for Relapse Prevention in Acute Myeloid
Leukemia
Kristoffer Hellstrand, Fredrik Bergh Thorén, Anna Martner, Jonas Söderholm, W. K. Hofmann, J. M. Rowe, Mats Brune
Annals of Hematology - 2011 -
The anionic amphiphile SDS is an antagonist for the human neutrophil formyl peptide receptor
1.
Fredrik Bergh Thorén, Jennie Karlsson, Claes Dahlgren, Huamei Forsman
Biochemical pharmacology - 2010 -
Immunotherapy with histamine dihydrochloride for the prevention of relapse in acute myeloid
leukemia.
Anna Martner, Fredrik Bergh Thorén, Johan Aurelius, Jonas Söderholm, Mats Brune, Kristoffer Hellstrand
Expert review of hematology - 2010 -
Post-consolidation immunotherapy with histamine dihydrochloride and interleukin-2 in
AML.
Ana Romero, Fredrik Bergh Thorén, Johan Aurelius, Galia Askarieh, Mats Brune, Kristoffer Hellstrand
Scandinavian journal of immunology - 2009 -
Histamine dihydrochloride and low-dose interleukin-2 as post-consolidation immunotherapy in acute myeloid
leukemia.
Fredrik Bergh Thorén, Ana Romero, Mats Brune, Kristoffer Hellstrand
Expert opinion on biological therapy - 2009 -
[Interferon-alpha can improve the prognosis in high-risk melanoma. Combination of surgery, cytostatics and natural IFN-alpha doubled the survival
rate]
Örjan Strannegård, Fredrik Bergh Thorén, Erik Lundgren
Läkartidningen - 2008 -
Cutting edge: Antioxidative properties of myeloid dendritic cells: protection of T cells and NK cells from oxygen radical-induced inactivation and
apoptosis
Fredrik Bergh Thorén, Åsa Betten, Ana Romero, Kristoffer Hellstrand
J Immunol - 2007 -
The CD16-/CD56bright subset of NK cells is resistant to oxidant-induced cell
death
Fredrik Bergh Thorén, Ana Romero, Svante Hermodsson, Kristoffer Hellstrand
J Immunol - 2007 -
Oxidant-induced cell death in lymphocytes: mechanisms of induction and
resistance
Fredrik Bergh Thorén
2007 -
NKp46 and NKG2D receptor expression in NK cells with CD56dim and CD56bright phenotype: regulation by histamine and reactive oxygen
species
Ana Romero, Fredrik Bergh Thorén, Mats Brune, Kristoffer Hellstrand
Br J Haematol - 2006 -
Oxygen radicals induce poly(ADP-ribose) polymerase-dependent cell death in cytotoxic
lymphocytes
Fredrik Bergh Thorén, Ana Romero, Kristoffer Hellstrand
J Immunol - 2006 -
Long-term survival benefit after adjuvant treatment of cutaneous melanoma with dacarbazine and low dose natural interferon alpha: A controlled, randomised multicentre
trial
R. Stadler, T. Luger, T. Bieber, U. Kohler, R. Linse, K. Technau, R. Schubert, K. Schroth, F. Vakilzadeh, M. Volkenandt, H. Gollnick, H. Von Eick, Fredrik Bergh Thorén, O. Strannegard
Acta Oncol - 2006 -
Changes in activation states of murine polymorphonuclear leukocytes (PMN) during inflammation: a comparison of bone marrow and peritoneal exudate
PMN
T. Itou, Vincent Collins, Fredrik Bergh Thorén, Claes Dahlgren, Anna Karlsson
Clinical and vaccine immunology - 2006 -
A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell
functions
Lars Bellner, Fredrik Bergh Thorén, Erik Nygren, Jan-Åke Liljeqvist, Anna Karlsson, Kristina Eriksson
J Immunol - 2005 -
Addition of histamine to interleukin 2 treatment augments type 1 T-cell responses in patients with melanoma in vivo: immunologic results from a randomized clinical trial of interleukin 2 with or without histamine (MP
104)
Anne Marie Asemissen, Carmen Scheibenbogen, Anne Letsch, Kristoffer Hellstrand, Fredrik Bergh Thorén, Kurt Gehlsen, Alexander Schmittel, Eckhard Thiel, Ulrich Keilholz
Clin Cancer Res - 2005 -
A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: role of NADPH oxidase-derived oxygen
radicals
Fredrik Bergh Thorén, Ana Romero, Magnus Lindh, Claes Dahlgren, Kristoffer Hellstrand
Journal of leukocyte biology - 2004 -
Activation of cytotoxic lymphocytes by interferon-alpha: role of oxygen radical-producing mononuclear
phagocytes
Markus Hansson, Ana Romero, Fredrik Bergh Thorén, Svante Hermodsson, Kristoffer Hellstrand
J Leukoc Biol - 2004