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Beidong Liu
Professor
Department of Chemistry & Molecular BiologyAbout Beidong Liu
Current position • Full professor (part-time), from 2023-09-01 • Full professor, from 2023-01-01 • Director of the Center for Large-scale cell-based screening (cmb.gu.se/english/research/microbiology/center-for-large-scale-cell-based-screening), from 2015-09-01
Research My present research interest is focused on deciphering mechanisms underlying the formation of membraneless originals and their roles in aging and aging-related diseases by developing and applying novel high-content screening techniques using yeast (Saccharomyces cerevisiae) as a model system. The powerful high throughput screening approach, developed in my group, enables me to study all the possible combinations between a phenotypic reporter of choice and a collection of gene mutants throughout the yeast genome in a few months (while a conventional manual test would take more than several decades). This approach makes it possible to pull out almost all components being part of any specific biological machinery and allows for an unbiased, genome-wide, identification of components and networks involved in, for example, stress granule regulation, protein phase separation condensate formation, protein quality control machinery, protein aggregate formation and inheritance and epigenetic silencing.
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Unveiling the Longevity Potential of Natural Phytochemicals: A Comprehensive Review of Active Ingredients in Dietary Plants and
Herbs
Yu Wang, Xiuling Cao, Jin Ma, Shenkui Liu, Xuejiao Jin, Beidong Liu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY - 2024 -
Genome-wide identification of resistance genes and response mechanism analysis of key gene knockout strain to catechol in Saccharomyces
cerevisiae
Hong Liao, Qian Li, Yulei Chen, Jiaye Tang, Borui Mou, Fujia Lu, Peng Feng, Wei Li, Jialian Li, Chun Fu, Wencong Long, Ximeng Xiao, Xuebing Han, Wenli Xin, Fengxuan Yang, Menggen Ma, Beidong Liu, Yaojun Yang, Hanyu Wang
FRONTIERS IN MICROBIOLOGY - 2024 -
Truncating the spliceosomal 'rope protein' Prp45 results in Htz1 dependent
phenotypes.
Kateřina Abrhámová, Martina Groušlová, Anna Valentová, Xinxin Hao, Beidong Liu, Martin Převorovský, Ondřej Gahura, František Půta, Per Sunnerhagen, Petr Folk
RNA Biology - 2024 -
Discovery of new strains for furfural degradation using adaptive laboratory evolution in Saccharomyces
cerevisiae
Q. Li, Z. Y. Zhang, E. Ayepa, Q. J. Xiang, X. M. Yu, K. Zhao, L. K. Zou, Y. F. Gu, X. Li, Q. Chen, X. P. Zhang, Y. J. Yang, X. J. Jin, H. D. Yin, Z. W. Liu, T. L. Tang, Beidong Liu, M. G. Ma
Journal of Hazardous Materials - 2023 -
Genome-wide identification of resistance genes and cellular analysis of key gene knockout strain under 5-hydroxymethylfurfural stress in Saccharomyces
cerevisiae
Qian Li, Peng Feng, Hao Tang, Fujia Lu, Borui Mou, Lan Zhao, Nan Li, Yaojun Yang, Chun Fu, Wencong Long, Ximeng Xiao, Chaohao Li, Wei Wu, Gang Wang, Beidong Liu, Tianle Tang, Menggen Ma, Hanyu Wang
BMC Microbiology - 2023 -
Calmodulin regulates protease versus co-chaperone activity of a
metacaspase
Anna Maria Eisele-Bürger, Frederik Eisele, Sandra Malmgren Hill, Xinxin Hao, Kara Schneider, Rahmi Imamoglu, David Balchin, Beidong Liu, F. Ulrich Hartl, Peter V. Bozhkov, Thomas Nyström
Cell Reports - 2023 -
Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative
Diseases
L. Z. Xiang, Y. A. Wang, S. K. Liu, Beidong Liu, X. J. Jin, X. L. Cao
International Journal of Molecular Sciences - 2023 -
The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces
cerevisiae
Rebecca Josefson, Navinder Kumar, Xinxin Hao, Beidong Liu, Thomas Nyström
Scientific Reports - 2023 -
A comprehensive review of pancreatic cancer and its therapeutic
challenges
Shan Jiang, Johan Bourghardt Fagman, Yunyun Ma, Jian Liu, C. Vihav, Cecilia Engström, Beidong Liu, Changyan Chen
Aging - 2022 -
Lsm7 phase-separated condensates trigger stress granule
formation
Michelle Lindström, Lihua Chen, Shan Jiang, Dan Zhang, Yuan Gao, J. Zheng, Xinxin Hao, Xiaoxue Yang, Arpitha Kabbinale, Johannes Thoma, Lisa Metzger, D. Y. Zhang, Xuefeng Zhu, H. S. Liu, Claes M Gustafsson, Björn Marcus Burmann, J. Winderickx, Per Sunnerhagen, Beidong Liu
Nature Communications - 2022 -
The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing
Regulator
X. D. Hu, X. J. Jin, X. L. Cao, Beidong Liu
International Journal of Molecular Sciences - 2022 -
Effects of pH alterations on stress- and aging-induced protein phase
separation
X. Jin, M. Zhou, S. Chen, D. Li, X. Cao, Beidong Liu
Cellular and Molecular Life Sciences - 2022 -
Genome-wide identification of resistance genes and transcriptome regulation in yeast to accommodate ammonium
toxicity
W. H. Fu, X. L. Cao, T. T. An, H. H. Zhao, J. Zhang, D. Q. Li, X. J. Jin, Beidong Liu
BMC Genomics - 2022 -
Genome-Wide Identification of Cellular Pathways and Key Genes That Respond to Sodium Bicarbonate Stress in Saccharomyces
cerevisiae
X. L. Cao, T. T. An, W. H. Fu, J. Zhang, H. H. Zhao, D. Q. Li, X. J. Jin, Beidong Liu
Frontiers in Microbiology - 2022 -
Retromer Complex and PI3K Complex II-Related Genes Mediate the Yeast (Saccharomyces cerevisiae) Sodium Metabisulfite Resistance
Response
X. J. Jin, H. H. Zhao, M. Zhou, J. Zhang, T. T. An, W. H. Fu, D. Q. Li, X. L. Cao, Beidong Liu
Cells - 2021 -
A Genome-Wide Screen in Saccharomyces cerevisiae Reveals a Critical Role for Oxidative Phosphorylation in Cellular Tolerance to Lithium
Hexafluorophosphate
X. J. Jin, J. Zhang, T. T. An, H. H. Zhao, W. H. Fu, D. Q. Li, S. K. Liu, X. L. Cao, Beidong Liu
Cells - 2021 -
An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality
control
Frederik Eisele, Anna Maria Eisele-Bürger, Xinxin Hao, Lisa Larsson Berglund, Johanna L Höög, Beidong Liu, Thomas Nyström
Cell Reports - 2021 -
Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and
toxicity.
Stefanie Andersson, Antonia Romero, Joana Isabel Rodrigues, Sansan Hua, Xinxin Hao, Therese Jacobson, Vivien Karl, Nathalie Becker, Arghavan Ashouri, Sebastien Rauch, Thomas Nyström, Beidong Liu, Markus J. Tamás
Journal of cell science - 2021 -
Functional Roles of Poly(ADP-Ribose) in Stress Granule Formation and
Dynamics
X. J. Jin, X. L. Cao, S. K. Liu, Beidong Liu
Frontiers in Cell and Developmental Biology - 2021 -
Isolation of aged yeast cells using biotin-streptavidin affinity
purification
X. Jin, X. Cao, Beidong Liu
Yeast Protocols - 2021 -
Genome-wide imaging-based phenomic screening using yeast (saccharomyces cerevisiae) strain
collections
X. Cao, X. Jin, Beidong Liu
Yeast Protocols. Methods in Molecular Biology, vol 2196. Xiao W. (red.) - 2021 -
Protein phase separation and its role in
tumorigenesis
Shan Jiang, Johan Bourghardt Fagman, Changyan Chen, Simon Alberti, Beidong Liu
eLife - 2020 -
Yeast mismatch repair components are required for stable inheritance of gene
silencing
Qian Liu, Xuefeng Zhu, Michelle Lindström, Yonghong Shi, Ju Zheng, Xinxin Hao, Claes M Gustafsson, Beidong Liu
Plos Genetics - 2020 -
Cellular Analysis and Comparative Transcriptomics Reveal the Tolerance Mechanisms of Candida tropicalis Toward
Phenol
H. Y. Wang, Q. Li, Y. Y. Peng, Z. Y. Zhang, X. L. Kuang, X. D. Hu, E. Ayepa, X. B. Han, G. T. Abrha, Q. J. Xiang, X. M. Yu, K. Zhao, L. K. Zou, Y. F. Gu, X. Li, X. Y. Li, Q. Chen, X. P. Zhang, Beidong Liu, M. G. Ma
Frontiers in Microbiology - 2020 -
Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication
threats
X. L. Li, Xuejiao Jin, S. Sharma, X. J. Liu, J. X. Zhang, Y. L. Niu, J. N. Li, Z. Li, J. J. Zhang, Q. H. Cao, W. Y. Hou, L. L. Du, Beidong Liu, H. Q. Lou
Plos Genetics - 2019 -
Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic
Stress
Roja Babazadeh, Doryaneh Ahmadpour, S. Jia, Xinxin Hao, Per O Widlund, Kara Schneider, Frederik Eisele, L. D. Edo, G. J. Smits, Beidong Liu, Thomas Nyström
Cell Reports - 2019 -
Loss of transcriptional control affects As(III)-induced protein
aggregation
Joana Isabel Rodrigues, Stefanie Andersson, Sansan Hua, Xinxin Hao, Therese Jacobson, Vivien Karl, Arghavan Ashouri, Thomas Nyström, Beidong Liu, Markus J. Tamás
Gordon Research Conference on Stress Proteins in Growth, Development & Disease 2019, Lucca, Italy - 2019 -
Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and
toxicity
Stefanie Andersson, Joana Isabel Rodrigues, Antonia Romero, Sansan Hua, Xinxin Hao, Therese Jacobson, Vivien Karl, Arghavan Ashouri, José García-Martínez, José Enrique Pérez-Ortín3 Pérez-Ortín, Thomas Nyström, Beidong Liu, Markus J. Tamás
International Conference on Yeast Genetics and Molecular Biology, Gothenburg, Sweden, workshop presentation (2019) - 2019 -
Genome-Wide Analysis of Glycine soja Response Regulator GsRR Genes Under Alkali and Salt
Stresses
C. Chen, A. L. Liu, H. Ren, Y. Yu, H. Z. Duanmu, X. B. Duan, X. L. Sun, Beidong Liu, Y. M. Zhu
Frontiers in Plant Science - 2018 -
GsSLAH3, a Glycine soja slow type anion channel homolog, positively modulates plant bicarbonate stress
tolerance
X. B. Duan, Y. Yu, H. Duanmu, C. Chen, X. L. Sun, L. Cao, Q. Li, X. D. Ding, Beidong Liu, Y. M. Zhu
Physiologia Plantarum - 2018 -
Genome-wide analysis and expression profiling of PP2C clade D under saline and alkali stresses in wild soybean and
Arabidopsis
C. Chen, Y. Yu, X. D. Ding, Beidong Liu, H. Z. Duanmu, D. Zhu, X. L. Sun, L. Cao, Nisa Zaib un, Q. Li, Y. M. Zhu
Protoplasma - 2018 -
Genome-wide analysis of Glycine soja ubiquitin (UBQ) genes and functional analysis of GsUBQ10 in response to alkaline
stress
C. Chen, R. R. Chen, S. Y. Wu, D. Zhu, X. L. Sun, Beidong Liu, Q. Li, Y. M. Zhu
Physiologia Plantarum - 2018 -
A Mitochondria-Associated Oxidative Stress Perspective on Huntington's
Disease
Ju Zheng, J. Winderickx, V. Franssens, Beidong Liu
Frontiers in Molecular Neuroscience - 2018 -
Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral
Sclerosis
Michelle Lindström, Beidong Liu
Frontiers in Molecular Neuroscience - 2018 -
Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin
exon-1
Ju Zheng, Junsheng Yang, Y. J. Choe, Xinxin Hao, Xiuling Cao, Q. Zhao, Y. J. Zhang, V. Franssens, F. U. Hartl, Thomas Nyström, J. Winderickx, Beidong Liu
Biochemical and Biophysical Research Communications - 2017 -
Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in
yeast
Lisa Larsson Berglund, Xinxin Hao, Beidong Liu, Julie Grantham, Thomas Nyström
Scientific Reports - 2017 -
The Glycine soja NAC transcription factor GsNAC019 mediates the regulation of plant alkaline tolerance and ABA
sensitivity
L. Cao, Y. Yu, X. D. Ding, D. Zhu, F. Yang, Beidong Liu, X. L. Sun, X. B. Duan, K. D. Yin, Y. M. Zhu
Plant Molecular Biology - 2017 -
A novel AP2/ERF family transcription factor from Glycine soja, GsERF71, is a DNA binding protein that positively regulates alkaline stress tolerance in
Arabidopsis
Y. Yu, X. B. Duan, X. D. Ding, C. Chen, D. Zhu, K. D. Yin, L. Cao, X. W. Song, P. H. Zhu, Q. Li, Z. U. Nisa, J. Y. Yu, J. Y. Du, Y. Song, H. Q. Li, Beidong Liu, Y. M. Zhu
Plant Molecular Biology - 2017 -
Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative
Diseases
Lihua Chen, Beidong Liu
Oxidative Medicine and Cellular Longevity - 2017 -
Yeast buddies helping to unravel the complexity of neurodegenerative
disorders
G. Fruhmann, D. Seynnaeve, Ju Zheng, K. Ven, S. Molenberghs, T. Wilms, Beidong Liu, J. Winderickx, V. Franssens
Mechanisms of Ageing and Development - 2017 -
GsCHX19.3, a member of cation/H+ exchanger superfamily from wild soybean contributes to high salinity and carbonate alkaline
tolerance
B. Jia, M. Sun, H. Duanmu, X. Ding, Beidong Liu, Y. Zhu, X. Sun
Scientific Reports - 2017 -
Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded
Proteins
Sarah Hanzén, Katarina Vielfort, Junsheng Yang, Friederike Roger, Veronica Andersson, Sara Zamarbide-Fores, Rebecca Andersson, Lisa Malm, G. Palais, B. Biteau, Beidong Liu, M. B. Toledano, Mikael Molin, Thomas Nyström
Cell - 2016 -
Spatial sequestration and detoxification of Huntingtin by the ribosome quality control
complex
Junsheng Yang, Xinxin Hao, Xiuling Cao, Beidong Liu, Thomas Nyström
Elife - 2016 -
Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar
Functions
Sandra Malmgren Hill, Xinxin Hao, Johan Grönvall, Stephanie Spikings-Nordby, Per O Widlund, T. Amen, Anna Jorhov, Rebecca Josefson, D. Kaganovich, Beidong Liu, Thomas Nyström
Cell Reports - 2016 -
Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in
yeast
Xuefeng Zhu, Lihua Chen, Jonas O P Carlsten, Qian Liu, Junsheng Yang, Beidong Liu, Claes M Gustafsson
Nucleic Acids Research - 2015 -
Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein
Aggregates
J. Song, Q. Yang, Junsheng Yang, Lisa C Larsson, Xinxin Hao, Xuefeng Zhu, Sandra Malmgren Hill, Marija Cvijovic, Julia Fernandez-Rodriguez, Julie Grantham, Claes M Gustafsson, Beidong Liu, Thomas Nyström
PLoS Genetics - 2014 -
The Yin and Yang of a
metacaspase
Beidong Liu
Cell Cycle - 2014 -
Stress granule-defective mutants deregulate stress responsive
transcripts
Xiaoxue Yang, Yi Shen, Elena Garre, Xinxin Hao, Daniel Krumlinde, Marija Cvijovic, Christina Arens, Thomas Nyström, Beidong Liu, Per Sunnerhagen
PLoS Genetics - 2014 -
Life-span extension by a metacaspase in the yeast Saccharomyces
cerevisiae
Sandra Malmgren Hill, Xinxin Hao, Beidong Liu, Thomas Nyström
Science - 2014 -
The mystery of aging and rejuvenation - a budding
topic
Thomas Nyström, Beidong Liu
Current Opinion in Microbiology - 2014 -
Protein quality control in time and space - links to cellular
aging.
Thomas Nyström, Beidong Liu
FEMS Yeast Research - 2014 -
Enhancing protein disaggregation restores proteasome activity in aged
cells
Veronica Andersson, Sarah Hanzén, Beidong Liu, Mikael Molin, Thomas Nyström
Aging-Us - 2013 -
Mediator Promotes CENP-A Incorporation at Fission Yeast
Centromeres
Jonas O P Carlsten, Zsolt Szilagyi, Beidong Liu, Marcela Davila Lopez, Erzsebet Szaszi, I. Djupedal, Thomas Nyström, K. Ekwall, Claes M Gustafsson, Xuefeng Zhu
Molecular and Cellular Biology - 2012 -
Mediator influences telomeric silencing and cellular life
span.
Xuefeng Zhu, Beidong Liu, Jonas O P Carlsten, Jenny Beve, Thomas Nyström, Lawrence Myers, Claes M Gustafsson
Molecular and cellular biology - 2011 -
Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent
silencing.
Antonio Caballero, Ana Ugidos, Beidong Liu, David Öling, Kristian Kvint, Xinxin Hao, Cora Mignat, Laurence Nachin, Mikael Molin, Thomas Nyström
Molecular cell - 2011 -
Segregation of protein aggregates involves actin and the polarity
machinery.
Beidong Liu, Lisa C Larsson, Vanessa Franssens, Xinxin Hao, Sandra Malmgren Hill, Veronica Andersson, Daniel Höglund, Jia Song, Xiaoxue Yang, David Öling, Julie Grantham, Joris Winderickx, Thomas Nyström
Cell - 2011 -
Cloning of two cellobiohydrolase genes from Trichodermaviride and heterogenous expression in yeast Saccharomyces
cerevisiae
Beidong Liu
Molecular Biology Reports - 2010 -
The Polarisome Is Required for Segregation and Retrograde Transport of Protein
Aggregates
Beidong Liu, Lisa C Larsson, Antonio Caballero, Xinxin Hao, David Öling, Julie Grantham, Thomas Nyström
Cell - 2010 -
Chemogenetic fingerprinting by analysis of cellular growth
dynamics.
Jonas Warringer, Dragi Anevski, Beidong Liu, Anders Blomberg
BMC chemical biology - 2008 -
Expression of the chitinase gene from Trichoderma aureoviride in Saccharomyces
cerevisiae
Beidong Liu
Applied Microbiology and Biotechnology - 2005 -
Cloning and expression of the endo-beta-glucanase III cDNA gene from Trichoderma viride
AS3.3711
Beidong Liu
Environmental Science - 2004