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Marcela Davila
Head of Unit
Core facilitiesAbout Marcela Davila
Current Position at GU
I'm Co-Head of the Bioinformatics and Data Centre at the Sahlgrenska Academy, where we provide:
- High throughput techniques for biomedical, clinical and pre-clinical research.
- Wide range of statistical and bioinformatics support and training.
- Cluster hardware and software infrastructure development
Education and Previous Experience
- During my research education (postdoc at Claes Gustafsson's group, PhD at Tore Samuelsson's group) I've been involved in the development of bioinformatics algorithms and analytical platforms.
- I am a co-founder of the Gothenburg Bioinformatics Network (GOTBIN) which intends to bring together all Gothenburg researchers for whom bioinformatics is a part of their research.
- I have also been involved in bioinformatics education, either by lecturing and organizing courses or by supervising students.
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Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human
cells.
Mara Doimo, Namrata Chaudhari, Sanna Abrahamsson, Valentin L'Hôte, Tran V H Nguyen, Andreas Berner, Mama Ndi, Alva Abrahamsson, Rabindra Nath Das, Koit Aasumets, Steffi Goffart, Jaakko L O Pohjoismäki, Marcela Davila Lopez, Erik Chorell, Sjoerd Wanrooij
Nucleic acids research - 2023 -
Development of a machine learning framework for radiation biomarker discovery and absorbed dose
prediction.
Björn Andersson, Britta Langen, Peidi Liu, Marcela Dávila López
Frontiers in oncology - 2023 -
PΨFinder: a practical tool for the identification and visualization of novel pseudogenes in DNA sequencing
data
Sanna Abrahamsson, Frida Eiengård, Anna Rohlin, Marcela Dávila López
BMC Bioinformatics - 2022 -
The proteomic signature of intestinal acute rejection in the
mouse
Mihai Oltean, Jasmine Bagge, George Dindelegan, Diarmuid T. Kenny, Antonio Molinaro, Mats Hellström, Ola Nilsson, C. Sihlbom, Anna Casselbrant, Marcela Dávila López, Michael Olausson
Metabolites - 2022 -
TC-hunter: identification of the insertion site of a transgenic gene within the host
genome
Vanja Börjesson , Angela Martinez-Monleon, Susanne Fransson, P. Kogner, J. I. Johnsen, J. Milosevic, Marcela Davila Lopez
Bmc Genomics - 2022 -
Comparison of online learning designs during the COVID-19 pandemic within bioinformatics courses in higher
education
Sanna Abrahamsson, Marcela Davila Lopez
Bioinformatics - 2021 -
The enigmatic RNase MRP of
kinetoplastids
Magnus Alm Rosenblad, Marcela Dávila López, Tore Samuelsson
Rna Biology - 2021 -
Comparison of DNA Methylation Profiles of Hemostatic Genes between Liver Tissue and Peripheral Blood within
Individuals
Martina Olsson Lindvall, Annelie Angerfors, Björn Andersson, Staffan Nilsson, Marcela Davila Lopez, L. Hansson, Tara M Stanne, Christina Jern
Thrombosis and Haemostasis - 2021 -
RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic
Profiling.
D. Scherer, Marcela Davila Lopez, B. Goeppert, Sanna Abrahamsson, R. González Silos, I. Nova, K. Marcelain, J.C. Roa, D. Ibberson, S.U. Umu, T. Ballestad Rounge, S. Roessler, J. Lorenzo Bermejo
Cancers - 2020 -
Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer
tumor
Patricia García, Carolina Bizama, Lorena Rosa, Jaime A. Espinoza, Helga Weber, Javier Cerda-Infante, Marianela Sánchez, Viviana P. Montecinos, Justo Lorenzo-Bermejo, Felix Boekstegers, Marcela Davila Lopez, Francisca Alfaro, Claudia Leiva-Acevedo, Zasha Parra, Diego Romero, Sumie Kato, Pamela Leal, Marcela Lagos, Juan Carlos Roa
Biological Research - 2020 -
A Comprehensive Sequencing-Based Analysis of Allelic Methylation Patterns in Hemostatic Genes in Human
Liver
Martina Olsson Lindvall, Marcela Davila Lopez, Sofia Klasson, L. Hansson, Staffan Nilsson, Tara M Stanne, Christina Jern
Thrombosis and Haemostasis - 2020 -
Soluble silica stimulates osteogenic differentiation and gap junction communication in human dental follicle
cells
Pamela Uribe, A. Johansson, R. Jugdaohsingh, J. J. Powell, Catarina Magnusson, Marcela Davila Lopez, Anna Westerlund, Maria Ransjö
Scientific Reports - 2020 -
Cardiomyopathy with lethal arrhythmias associated with inactivation of
KLHL24
Carola Oldfors Hedberg, Alexandra Abramsson, D. P. S. Osborn, O. Danielsson, A. Fazlinezhad, Y. Nilipour, L. Hubbert, I. Nennesmo, Kittichate Visuttijai, J. Bharj, E. Petropoulou, A. Shoreim, B. Vona, N. Ahangari, Marcela Davila Lopez, M. Doosti, Rakesh Kumar Banote, R. Maroofian, Malin Edling, M. Taherpour, Henrik Zetterberg, E. G. Karimiani, Anders Oldfors, Y. Jamshidi
Human Molecular Genetics - 2019 -
A Modeling Approach for Bioinformatics
Workflows
Laiz Heckmann Barbalho de Figueroa, Rema Salman, Jennifer Horkhoff, Soni Chauhan, Marcela Davila Lopez, Francisco Gomes de Oliveira Neto, Alexander Schliep
The Practice of Enterprise Modeling - 12th {IFIP} Working Conference, PoEM 2019, Luxembourg, Luxembourg, November 27-29, 2019, Proceedings - 2019 -
Hemostatic Genes Exhibit a High Degree of Allele-Specific Regulation in
Liver
Martina Olsson Lindvall, L. Hansson, Sofia Klasson, Marcela Davila Lopez, Christina Jern, Tara M Stanne
Thrombosis and Haemostasis - 2019 -
Loss of the Mediator subunit Med20 affects transcription of tRNA and other non-coding RNA genes in fission
yeast
Jonas O P Carlsten, Xuefeng Zhu, Marcela Davila Lopez, Tore Samuelsson, Claes M Gustafsson
Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms - 2016 -
Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived
xenografts.
Joydeep Bhadury, Berglind Osk Einarsdottir, Agnieszka Podraza, Roger Olofsson Bagge, Ulrika Stierner, Lars Ny, Marcela Davila Lopez, Jonas A Nilsson
Oncotarget - 2016 -
Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells - evidence of unique microRNA
cargos.
Taral R Lunavat, Lesley Cheng, Dae-Kyum Kim, Joydeep Bhadury, Su Chul Jang, Cecilia Lässer, Robyn A Sharples, Marcela Davila Lopez, Jonas A Nilsson, Yong Song Gho, Andrew F Hill, Jan Lötvall
RNA biology - 2015 -
Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence
element
Elisabeth Jemt, Örjan Persson, Yonghong Shi, Majda Mehmedovic, Jay (Jennifer) Uhler, Marcela Davila Lopez, C. Freyer, Claes M Gustafsson, Tore Samuelsson, Maria Falkenberg
Nucleic Acids Research - 2015 -
Whole exome sequencing reveals mutations in NARS2 and PARS2, encoding the mitochondrial asparaginyl-tRNA synthetase and prolyl-tRNA synthetase, in patients with Alpers
syndrome.
Kalliopi Sofou, Gittan Kollberg, Maria Holmström, Marcela Davila Lopez, Niklas Darin, Claes M Gustafsson, Elisabeth Holme, Anders Oldfors, Mar Tulinius, Jorge Asin-Cayuela
Molecular genetics & genomic medicine - 2015 -
Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment
decisions.
Berglind Osk Einarsdottir, Roger Olofsson Bagge, Joydeep Bhadury, Henrik Jespersen, Jan Mattsson, Lisa M Nilsson, Katarina Truvé, Marcela Davila Lopez, Peter Naredi, Ola Nilsson, Ulrika Stierner, Lars Ny, Jonas A Nilsson
Oncotarget - 2014 -
Mediator Can Regulate Mitotic Entry and Direct Periodic Transcription in Fission
Yeast
Gabor Banyai, Marcela Davila Lopez, Zsolt Szilagyi, Claes M Gustafsson
Molecular and Cellular Biology - 2014 -
Identification of tumorigenic and therapeutically actionable mutations in transplantable mouse tumor cells by exome
sequencing.
Joydeep Bhadury, Marcela Davila Lopez, Somsundar Veppil Muralidharan, Lisa M Nilsson, Jonas A Nilsson
Oncogenesis - 2013 -
Polyglucosan body myopathy caused by defective ubiquitin ligase
RBCK1.
Johanna Nilsson, Benedikt Schoser, Pascal Laforet, Ognian Kalev, Christopher Lindberg, Norma B Romero, Marcela Davila Lopez, Hasan O Akman, Karim Wahbi, Stephan Iglseder, Christian Eggers, Andrew G Engel, Salvatore DiMauro, Anders Oldfors
Annals of neurology - 2013 -
MTERF1 Binds mtDNA to Prevent Transcriptional Interference at the Light-Strand Promoter but Is Dispensable for rRNA Gene Transcription
Regulation
M. Terzioglu, B. Ruzzenente, J. Harmel, A. Mourier, Elisabeth Jemt, Marcela Davila Lopez, C. Kukat, J. B. Stewart, R. Wibom, C. Meharg, B. Habermann, Maria Falkenberg, Claes M Gustafsson, C. B. Park, N. G. Larsson
Cell Metabolism - 2013 -
Cyclin dependent kinase 8 regulates mitotic commitment in fission
yeast
Zsolt Szilagyi, Gabor Banyai, Marcela Davila Lopez, C. I. McInerny, Claes M Gustafsson
Molecular and Cellular Biology - 2012 -
Mediator Promotes CENP-A Incorporation at Fission Yeast
Centromeres
Jonas O P Carlsten, Zsolt Szilagyi, Beidong Liu, Marcela Davila Lopez, Erzsebet Szaszi, I. Djupedal, Thomas Nyström, K. Ekwall, Claes M Gustafsson, Xuefeng Zhu
Molecular and Cellular Biology - 2012 -
Histone modifications influence mediator interactions with
chromatin.
Xuefeng Zhu, Yongqiang Zhang, Gudrun Bjornsdottir, Zhongle Liu, Amy Quan, Michael Costanzo, Marcela Davila Lopez, Jakub Orzechowski Westholm, Hans Ronne, Charles Boone, Claes M Gustafsson, Lawrence Myers
Nucleic acids research - 2011 -
eGOB: eukaryotic Gene Order
Browser.
Marcela Davila Lopez, Tore Samuelsson
Bioinformatics (Oxford, England) - 2011 -
Evolution of protein and non-coding RNA genes studied with comparative
genomics
Marcela Davila Lopez
2010 -
Analysis of Gene Order Conservation in Eukaryotes Identifies Transcriptionally and Functionally Linked
Genes
Marcela Davila Lopez, Juan Jose Martinez Guerra, Tore Samuelsson
PLOS ONE - 2010 -
Conserved and variable domains of RNase MRP
RNA
Marcela Davila Lopez, Magnus Alm Rosenblad, Tore Samuelsson
RNA Biology - 2009 -
Early evolution of histone mRNA 3' end
processing.
Marcela Davila Lopez, Tore Samuelsson
RNA - 2008 -
Computational screen for spliceosomal RNA genes aids in defining the phylogenetic distribution of major and minor spliceosomal
components
Marcela Davila Lopez, Magnus Alm Rosenblad, Tore Samuelsson
Nucleic Acids Research - 2008 -
Computational screen for spliceosomal RNA genes aids in defining the phylogenetic distribution of the major and minor spliceosomal
components
Marcela Davila Lopez, Magnus Alm Rosenblad, Tore Samuelsson
RNA Society Meeting 2008 - 2008 -
A histone 3' end processing machinery in
protozoa
Tore Samuelsson, Marcela Davila Lopez
5th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) & 6th European Conference on Computational Biology (ECCB) - 2007 -
Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human
enzymes.
Magnus Alm Rosenblad, Marcela Davila Lopez, Paul Piccinelli, Tore Samuelsson
Nucleic acids research - 2006