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Madeleine Rådinger
Avd-/Sektionschef, bitr, inst
Department of Internal Medicine and Clinical NutritionAbout Madeleine Rådinger
Title: PhD, Associate professor Position: Senior Lecturer, Chairman of Krefting Research Centre
Madeleine Rådinger graduatedfrom the University of Gothenburg with an MSc degree in Molecular biology, and in2006 she received a PhD in Respiratory Medicine and Allergologyat the University of Gothenburg. After her PhD, she took on a 2.5 years postdoctoral position at the Laboratory of Allergic Diseases, National Institute of Allergic and Infection Diseases, the National Institute of Health (NIH), in Bethesda, USA. She returned to the University of Gothenburg in 2010 and in 2013, she became Associate professorin Immunology.
Research
Rådinger research focuses on increasing the understanding of the immune systemin subgroups of asthma, including the contribution of immune regulatory microRNAs. The ultimate goal is to identify molecular drivers linked to clinical features in asthma subgroups, for stratification for targeted therapy, diagnosis and potentially identification of new therapeutic targets.
Her research is funded by the VBG group Herman Krefting Foundation for Asthma and Allergy Research, the Swedish Research Council, the Swedish Heart and Lung foundation, the Swedish Foundation for Strategic Research and ALF.
Rådinger collaborates with several national and internationalm research groups studyingmimmunology, respiratory research and microRNA biology. In 2019, she was awarded the big grant from the Swedish association for allergy research (SFFA) and the Swedish Cancer-and Allergy Foundation environmental medical award for her research.
Group members
- Elisabeth Ax– Industrial PhD student together with AstraZeneca
- Emma Boberg – PhD student
- Carina Malmhäll – PhD/laboratory engineer
- Jenny Calvén – postdoctoral research fellow
- Julie Weidner – postdoctoral research fellow
Articles
Madeleine Rådinger receives Swedish Association for Allergology’s major 2019 scholarship
Key publications
1. Malmhäll C, Alawieh S, Lu Y, Sjöstrand M, Bossios A, Eldh M and Rådinger M. 2014. MicroRNA-155 is essential for TH2 mediated allergen-induced eosinophilic inflammation in the lung. J Allergy Clin Immuol.2014 May;133(5):1429-38. This is the first study to describe a role for microRNA-155 in the regulation of type 2 mediated allergic eosinophilic inflammation in a mouse model of asthma.
2.Johansson K, Malmhäll C, Ramos-Ramirez P and Rådinger M.2017.MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation. J Allergy Clin Immunol.2017 Mar;139(3):1007-1016. This is the first study to describe aregulatoryrole for a microRNAin ILC2 functionality.
3.Malmhäll C, Weidner J, Rådinger M. 2019. MicroRNA-155 expression suggests a sexdisparity in innate lymphoid cells at the single-cell level.Cell Mol Immunol.2019 Oct 10. doi: 10.1038/s41423-019-0303-4. This is the first study to describethat human circulating ILCs express microRNA-155 and that this expression is higher in females.
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Level of education, but not occupation, is differentially associated with asthma phenotypes in
adults
Muwada Bashir Awad Bashir, Rani Basna, Göran Wennergren, Madeleine Rådinger, Helena Backman, Emma Goksör, Jan Lötvall, Linda Ekerljung, Hannu Kankaanranta, Bright I Nwaru
Clinical and Translational Allergy - 2024 -
Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma
Study
Özuygur Ermis, Magnus P Borres, Rani Basna, Linda Ekerljung, Carina Malmhäll, Emma Goksör, Göran Wennergren, Madeleine Rådinger, Jan Lötvall, Bo Lundbäck, Hannu Kankaaranta, Bright I Nwaru
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 2023 -
Physiological estrogen levels are dispensable for the sex difference in immune responses during allergen-induced airway
inflammation
Aidan Barrett, Piotr Humeniuk, Christina Drevinge, Carmen Corciulo, Julie Weidner, Madeleine Rådinger, Hans Carlsten, Julia M. Scheffler, Ulrika Islander
Immunobiology - 2023 -
Exogenous female sex steroid hormones and new-onset asthma in women: a matched case-control
study
Guo-Qiang Zhang, Rani Basna, Maya B Mathur, Cecilia Lässer, Roxana Mincheva, Linda Ekerljung, Göran Wennergren, Madeleine Rådinger, Bo Lundbäck, Hannu Kankaanranta, Bright I Nwaru
BMC medicine - 2023 -
Sensitization patterns to cat molecular allergens in subjects with allergic sensitization to cat
dander
Özuygur Ermis, Aram Norouzi, Magnus P Borres, Rani Basna, Linda Ekerljung, Carina Malmhäll, Emma Goksör, Göran Wennergren, Madeleine Rådinger, Jan Lötvall, Hannu Kankaanranta, Bright I Nwaru
Clinical and translational allergy - 2023 -
Comparison of clinician diagnosis of COVID-19 with real time polymerase chain reaction in an adult-representative population in
Sweden
Eman Quraishi, Chiamaka Jibuaku, Daniil Lisik, Göran Wennergren, Jan Lötvall, Fredrik Nyberg, Linda Ekerljung, Madeleine Rådinger, Hannu Kankaanranta, Bright I Nwaru
Respiratory research - 2023 -
Underdiagnosis and misclassification of COPD in Sweden - A Nordic Epilung
study
M. Axelsson, H. Backman, Bright I Nwaru, C. Stridsman, Lowie E G W Vanfleteren, L. Hedman, P. Piirila, J. Jalasto, A. Langhammer, Hannu Kankaanranta, Madeleine Rådinger, Linda Ekerljung, E. Ronmark, A. Lindberg
Respiratory Medicine - 2023 -
The Serum/Glucocorticoid-Regulated Kinase 1 Is Targeted by miR-19a in CD4+T
Cells
Julie Weidner, Carina Malmhäll, Vahid Arabkari, Aidan Barrett, Emma Boberg, Linda Ekerljung, Madeleine Rådinger
Cells - 2023 -
Sex Disparities in Asthma Development and Clinical Outcomes: Implications for Treatment
Strategies
Guo-Qiang Zhang, Özuygur Ermis, Madeleine Rådinger, A. Bossios, Hannu Kankaanranta, Bright I Nwaru
Journal of Asthma and Allergy - 2022 -
Eosinophilic airway diseases: basic science, clinical manifestations and future
challenges.
Christer Janson, Leif Bjermer, Lauri Lehtimäki, Hannu Kankaanranta, Jussi Karjalainen, Alan Altraja, Valentyna Yasinska, Bernt Aarli, Madeleine Rådinger, Johan Hellgren, Magnus Lofdahl, Peter H Howarth, Celeste Porsbjerg
European clinical respiratory journal - 2022 -
Role of airway epithelial cell miRNAs in
asthma
E. Boateng, D. Kovacevic, V. Oldenburg, Madeleine Rådinger, S. Krauss-Etschmann
Frontiers in Allergy - 2022 -
Rapamycin Dampens Inflammatory Properties of Bone Marrow ILC2s in IL-33-Induced Eosinophilic Airway
Inflammation
Emma Boberg, Julie Weidner, Carina Malmhäll, Jenny Calvén , Carmen Corciulo, Madeleine Rådinger
Frontiers in Immunology - 2022 -
Spotlight on microRNAs in allergy and
asthma
Julie Weidner, S. Bartel, A. Kilic, U. M. Zissler, H. Renz, J. Schwarze, C. B. Schmidt-Weber, T. Maes, A. Rebane, S. Krauss-Etschmann, Madeleine Rådinger
Allergy - 2021 -
Severe Asthma in a General Population Study: Prevalence and Clinical
Characteristics
Lina Rönnebjerg, M. Axelsson, Hannu Kankaanranta, H. Backman, Madeleine Rådinger, Bo Lundbäck, Linda Ekerljung
Journal of Asthma and Allergy - 2021 -
Immune-Associated Proteins Are Enriched in Lung Tissue-Derived Extracellular Vesicles during Allergen-Induced Eosinophilic Airway
Inflammation
Cecilia Lässer, Yasunari Kishino, Kyong-Su Park, Ganesh V Shelke, Nasibeh Karimi, Shintaro Suzuki, Lilit Hovhannisyan, Madeleine Rådinger, Jan Lötvall
International Journal of Molecular Sciences - 2021 -
The triad of current asthma, rhinitis and eczema is uncommon among adults: Prevalence, sensitization profiles, and risk
factors
Teet Pullerits, Erik P Rönmark, Linda Ekerljung, Mona Palmqvist, Monica Arvidsson, Roxana Mincheva, Helena Backman, Hannu Kankaanranta, Pinja Ilmarinen, Madeleine Rådinger, Bo Lundbäck, Bright I Nwaru
Respiratory Medicine - 2021 -
Adiponectin/AdipoR1 Axis Promotes IL-10 Release by Human Regulatory T
Cells
Patricia Ramos-Ramírez, Carina Malmhäll, O. Tliba, Madeleine Rådinger, Apostolos Bossios
Frontiers in Immunology - 2021 -
The airway epithelium—a central player in asthma
pathogenesis
Jenny Calvén , Elisabeth Ax, Madeleine Rådinger
International Journal of Molecular Sciences - 2020 -
Sex steroid hormones and asthma in women: state-of-the-art and future research
perspectives.
Guo-Qiang Zhang, Apostolos Bossios, Madeleine Rådinger, Bright I Nwaru
Expert review of respiratory medicine - 2020 -
Decreased COPD prevalence in Sweden after decades of decrease in
smoking.
Helena Backman, Lowie E G W Vanfleteren, Anne Lindberg, Linda Ekerljung, Caroline Stridsman, Malin Axelsson, Ulf Nilsson, Bright I Nwaru, Sami Sawalha, Berne Eriksson, Linnea Hedman, Madeleine Rådinger, Sven-Arne Jansson, Anders Ullman, Hannu Kankaanranta, Jan Lötvall, Eva Rönmark, Bo Lundbäck
Respiratory research - 2020 -
Interplay Between the IL-33/ST2 Axis and Bone Marrow ILC2s in Protease Allergen-Induced IL-5-Dependent
Eosinophilia
Emma Boberg, Kristina Johansson, Carina Malmhäll, Jenny Calvén , Julie Weidner, Madeleine Rådinger
Frontiers in Immunology - 2020 -
House Dust Mite Induces Bone Marrow IL-33-Responsive ILC2s and T-H
Cells
Emma Boberg, Kristina Johansson, Carina Malmhäll, Julie Weidner, Madeleine Rådinger
International Journal of Molecular Sciences - 2020 -
T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular
vesicles
Elisabeth Ax, Z. Jevnikar, Aleksander Cvjetkovic, Carina Malmhäll, H. Olsson, Madeleine Rådinger, Cecilia Lässer
Respiratory Research - 2020 -
Circulating microRNAs correlate to clinical parameters in individuals with allergic and non-allergic
asthma
Julie Weidner, Linda Ekerljung, Carina Malmhäll, N. Miron, Madeleine Rådinger
Respiratory Research - 2020 -
Cohort profile: the West Sweden Asthma Study (WSAS): a multidisciplinary population-based longitudinal study of asthma, allergy and respiratory conditions in
adults
Bright I Nwaru, Linda Ekerljung, Madeleine Rådinger, Anders Bjerg, Roxana Mincheva, Carina Malmhäll, Malin Axelsson, Göran Wennergren, Jan Lötvall, Bo Lundbäck
BMJ open - 2019 -
Furry animal allergen component sensitization and clinical outcomes in adult asthma and
rhinitis.
Bright I Nwaru, Shintaro Suzuki, Linda Ekerljung, Sigrid Sjölander, Roxana Mincheva, Erik P Rönmark, Madeleine Rådinger, Eva Rönmark, Magnus P. Borres, Bo Lundbäck, Jan Lötvall
The journal of allergy and clinical immunology. In practice - 2019 -
Changes in the prevalence of asthma and respiratory symptoms in western Sweden between 2008 and
2016.
Eivind Borna, Bright I Nwaru, Anders Bjerg, Roxana Mincheva, Madeleine Rådinger, Bo Lundbäck, Linda Ekerljung
Allergy - 2019 -
microRNAs in asthma pathogenesis - from mouse to
man
Julie Weidner, Carina Malmhäll, Madeleine Rådinger
Journal of Translational Genetics and Genomics - 2019 -
No difference in human mast cells derived from peanut allergic versus non-allergic
subjects
L. F. Larsen, N. Juel-Berg, A. Hansen, K. S. Hansen, E. N. C. Mills, R. van Ree, Madeleine Rådinger, L. K. Poulsen, B. M. Jensen
Immunity Inflammation and Disease - 2018 -
Lanosterol Synthase Regulates Human Rhinovirus Replication in Human Bronchial Epithelial
Cells
Cristopher McCrae, A. Dzgoev, Marcus Ståhlman, J. Horndahl, R. Svard, A. Grosse, T. Grosskopf, M. A. Skujat, N. Williams, S. Schubert, C. Echeverri, C. Jackson, A. Guedan, R. Solari, O. Vaarala, M. Kraan, Madeleine Rådinger
American Journal of Respiratory Cell and Molecular Biology - 2018 -
MicroRNAs in type 2
immunity
Kristina Johansson, Julie Weidner, Madeleine Rådinger
Cancer Letters - 2018 -
Bone marrow type 2 innate lymphoid cells: a local source of interleukin-5 in interleukin-33-driven
eosinophilia
Kristina Johansson, Carina Malmhäll, Patricia Ramos-Ramírez, Madeleine Rådinger
Immunology - 2018 -
Krefting Research Centre: Astma och allergi från epidemiologi till
lab
Jan Lötvall, Bo Lundbäck, Göran Wennergren, Bright I Nwaru, Linda Ekerljung, Cecilia Lässer, Madeleine Rådinger
Lung & Allergiforum - 2018 -
Sepsis-Like Systemic Inflammation Induced by Nano-Sized Extracellular Vesicles From
Feces
K. S. Park, J. Lee, C. Lee, H. T. Park, J. W. Kim, O. Y. Kim, S. R. Kim, Madeleine Rådinger, H. Y. Jung, J. Park, Jan Lötvall, Y. S. Gho
Frontiers in Microbiology - 2018 -
Altered miR-155 Expression in Allergic Asthmatic
Airways
Carina Malmhäll, Kristina Johansson, C. Winkler, Sahar Alawieh, Linda Ekerljung, Madeleine Rådinger
Scandinavian Journal of Immunology - 2017 -
MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway
inflammation
Kristina Johansson, Carina Malmhäll, Patricia Ramos-Ramírez, Madeleine Rådinger
Journal of Allergy and Clinical Immunology - 2017 -
Precursor B Cells Increase in the Lung during Airway Allergic Inflammation: A Role for B Cell-Activating
Factor
Konstantinos Samitas, Carina Malmhäll, Madeleine Rådinger, Patricia Ramos-Ramírez, You Lu, Tünde Deák, M. Semitekolou, M. Gaga, Margareta Sjöstrand, Jan Lötvall, Apostolos Bossios
Plos One - 2016 -
Interferon-gamma enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus
aureus
E. J. Swindle, J. M. Brown, Madeleine Rådinger, F. R. DeLeo, D. D. Metcalfe
Immunology - 2015 -
Assay of mast cell
mediators.
Madeleine Rådinger, Bettina M Jensen, Emily Swindle, Alasdair M Gilfillan
Methods in molecular biology (Clifton, N.J.) - 2015 -
Mast cell exosomes promote lung adenocarcinoma cell proliferation - role of KIT-stem cell factor
signaling
Xiao Hui, Cecilia Lässer, Ganesh V Shelke, Juan Wang, Madeleine Rådinger, Taral R Lunavat, Carina Malmhäll, Lihui Lin, Jia Lin, Li Li, Jan Lötvall
Cell Communication and Signaling - 2014 -
CD34+ eosinophil-lineage-committed cells in the mouse
lung.
Apostolos Bossios, Madeleine Rådinger
Methods in molecular biology (Clifton, N.J.) - 2014 -
MicroRNA-155 is essential for TH2-mediated allergen-induced eosinophilic inflammation in the
lung.
Carina Malmhäll, Sahar Alawieh, You Lu, Margareta Sjöstrand, Apostolos Bossios, Maria Eldh, Madeleine Rådinger
Journal of Allergy and Clinical Immunology - 2014 -
Toll-like receptor expression in severe asthma with chronic
rhinosinusitis
Carina Malmhäll, Apostolos Bossios, Margareta Sjöstrand, Bo Lundbäck, Jan Lötvall, Madeleine Rådinger
Clinical and Translational Allergy Vol 3, Suppl 1 EAACI International Severe Asthma Forum (ISAF 2012) Gothenburg, Sweden. 11-13 October 2012. Clinical and Translational Allergy - 2013 -
Circulating eosinophil progenitors express major trafficking related molecules and are more activated compared to mature eosinophils in patients with
asthma
You Lu, Carina Malmhäll, Margareta Sjöstrand, Madeleine Rådinger, Bo Lundbäck, Jan Lötvall, Apostolos Bossios
Clinical and Translational Allergy - 2013 -
Repeated allergen exposure reduce early phase airway response and leukotriene release despite upregulation of 5-lipoxygenase
pathways.
Zhi-Hua Cui, Madeleine Rådinger, Margareta Sjöstrand, Jan Lötvall
Clinical and translational allergy - 2012 -
Immunophenotyping of Circulating T Helper Cells Argues for Multiple Functions and Plasticity of T Cells In Vivo in Humans - Possible Role in
Asthma
Carina Malmhäll, Apostolos Bossios, Madeleine Rådinger, Margareta Sjöstrand, You Lu, Bo Lundbäck, Jan Lötvall
Plos One - 2012 -
Glycogen synthase kinase-3b is a prosurvival signal for the maintenance of human mast cell
homeostasis
Madeleine Rådinger, D Smrz, DD Metcalfe, AM Gilfillan
Journal of Immunology - 2011 -
Current update on eosinophilic lung diseases and anti-IL-5
treatment
Konstantinos Samitas, Madeleine Rådinger, Apostolos Bossios
Recent patents on anti-infective drug discovery - 2011 -
Expansion of CD4 + CD25 + and CD25- T-Bet, GATA-3, Foxp3 and RORγt Cells in Allergic Inflammation, Local Lung Distribution and Chemokine Gene
Expression.
You Lu, Carina Malmhäll, Margareta Sjöstrand, Madeleine Rådinger, Serena O'Neil, Jan Lötvall, Apostolos Bossios
PloS one - 2011 -
Local proliferation and mobilization of CCR3(+) CD34(+) eosinophil-lineage-committed cells in the
lung.
Madeleine Rådinger, Apostolos Bossios, Margareta Sjöstrand, You Lu, Carina Malmhäll, A-K Dahlborn, James J Lee, Jan Lötvall
Immunology - 2011 -
New production of eosinophils and the corresponding Th1/Th2 balance in the lungs after allergen exposure in BALB/c and C57BL/6
mice
You Lu, Margareta Sjöstrand, Carina Malmhäll, Madeleine Rådinger, Prescilla Jeurink, Jan Lötvall, Apostolos Bossios
Scandinavian Journal of Immunology - 2010 -
Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast
cells.
Madeleine Rådinger, Hye Sun Kuehn, Mi-Sun Kim, Dean D Metcalfe, Alasdair M Gilfillan
Journal of immunology (Baltimore, Md. : 1950) - 2010 -
Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast
cells.
Hye Sun Kuehn, Madeleine Rådinger, Jared M Brown, Khaled Ali, Bart Vanhaesebroeck, Michael A Beaven, Dean D Metcalfe, Alasdair M Gilfillan
Journal of cell science - 2010 -
Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord
blood.
Madeleine Rådinger, Bettina M Jensen, Hye Sun Kuehn, Arnold Kirshenbaum, Alasdair M Gilfillan
Current protocols in immunology / edited by John E. Coligan ... [et al.] - 2010 -
Measuring mast cell mediator
release.
Hye Sun Kuehn, Madeleine Rådinger, Alasdair M Gilfillan
Current protocols in immunology / edited by John E. Coligan ... [et al.] - 2010 -
Eosinophil progenitors in allergy and asthma - do they
matter?
Madeleine Rådinger, Jan Lötvall
Pharmacology & therapeutics - 2009 -
GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2)
gene.
Qiu Z, Dyer KD, Xie Z, Madeleine Rådinger, Rosenberg HF
Journal of Biological Chemistry - 2009 -
The multiple roles of phosphoinositide 3-kinase in mast cell
biology.
MS Kim, Madeleine Rådinger, AM Gilfillan
Trends in immunology - 2008 -
Regulation of allergen-induced bone marrow eosinophilopoiesis: role of CD4(+) and CD8(+) T
cells.
Madeleine Rådinger, Apostolos Bossios, A-S Alm, P Jeurink, You Lu, Carina Malmhäll, Margareta Sjöstrand, Jan Lötvall
Allergy - 2007 -
Regulatory role of CD8+ T lymphocytes in bone marrow
eosinophilopoiesis
Madeleine Rådinger, Svetlana Sergejeva, Anna-Karin Johansson, Carina Malmhäll, Apostolos Bossios, Margareta Sjöstrand, J. J. Lee, Jan Lötvall
Respir Res - 2006 -
Local and systemic mechanisms of allergen-induced airway
inflammation
Madeleine Rådinger
2006 -
Airway allergen exposure stimulates bone marrow eosinophilia partly via
IL-9
B. Sitkauskiene, Madeleine Rådinger, Apostolos Bossios, Anna-Karin Johansson, R. Sakalauskas, Jan Lötvall
Respir Res - 2005 -
Effects of the antifungal imidazole ketoconazole on CYPIA and CYP3A in rainbow trout and
killifish
Tove Hegelund, Karin Ottosson, Madeleine Rådinger, Peter Tomberg, Malin C. Celander
Environmental Toxicology and Chemistry - 2004 -
Eotaxin-2 regulates newly produced and CD34 airway eosinophils after allergen
exposure
Madeleine Rådinger, Anna-Karin Johansson, Brigita Sitkauskiene, Margareta Sjöstrand, Jan Lötvall
J Allergy Clin Immunol - 2004