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Liisa Arike
Researcher
Core facilities-
BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during
infection
Anandi Rajan, Pablo Gallego, Brendan Dolan, Piyush Patel, Chinmay Dwibedi, Ana S. Luis, Sergio Trillo-Muyo, Liisa Arike, Sjoerd van der Post, Magnus Simrén, Thaher Pelaseyed
GUT MICROBES - 2024 -
Metaproteomics reveals parallel utilization of colonic mucin glycans and dietary fibers by the human gut
microbiota
Grete Raba, Ana S. Luis, Hannah Schneider, Indrek Morell, Chunsheng Jin, Signe Adamberg, Gunnar C. Hansson, Kaarel Adamberg, Liisa Arike
ISCIENCE - 2024 -
Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen
infection
George M. H. Birchenough, Björn O. Schröder, Sinan Sharba, Liisa Arike, Christian V Recktenwald, F. Puertolas-Balint, Mahadevan Subramani, Karl Hansson, B. Yilmaz, Sara K. Lindén, Fredrik Bäckhed, Gunnar C. Hansson
Cell Reports - 2023 -
Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell
glycosylation
R. Song, W. McAlpine, A. M. Fond, E. Nair-Gill, J. H. Choi, E. E. L. Nystrom, Liisa Arike, S. Field, X. H. Li, J. A. SoRelle, J. J. Moresco, E. M. Y. Moresco, J. R. Yates, P. Azadi, J. Ni, George M. H. Birchenough, B. Beutler, E. E. Turer
Nature Communications - 2023 -
Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus
layer
Jack D. A. Sharpen, Brendan Dolan, Elisabeth E. L. Nyström, George M. H. Birchenough, Liisa Arike, Beatriz Martinez Abad, Malin E V Johansson, Gunnar C. Hansson, Christian V Recktenwald
Nature Communications - 2022 -
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier
function
Elisabeth E. L. Nyström, Beatriz Martinez Abad, Liisa Arike, George M. H. Birchenough, E. B. Nonnecke, P. A. Castillo, Frida Svensson, C. L. Bevins, Gunnar C. Hansson, Malin E V Johansson
Science - 2021 -
Metaproteomics Analysis of Host–Microbiota
Interfaces
Sjoerd van der Post, Liisa Arike
Shotgun Proteomics - 2021 -
IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during
weaning
Elena Layunta, Sofia Jäverfelt, Brendan Dolan, Liisa Arike, Thaher Pelaseyed
Cell Reports - 2021 -
Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and
Microbiota
Liisa Arike, A. Seiman, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E V Johansson, Gunnar C. Hansson
Cell Reports - 2020 -
Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and
traps
Liisa Arike, Gunnar C. Hansson, Christian V Recktenwald
Analytical Biochemistry - 2020 -
The human transmembrane mucin MUC17 responds to TNF alpha by increased presentation at the plasma
membrane
Hannah Schneider, Evelin Berger, Brendan Dolan, Beatriz Martinez Abad, Liisa Arike, Thaher Pelaseyed, Gunnar C. Hansson
Biochemical Journal - 2019 -
Normal calcium-activated anion secretion in a mouse selectively lacking TMEM16A in intestinal
epithelium
Génesis Vega, Anita Guequén, Malin E V Johansson, Liisa Arike, Beatriz Martinez Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Frontiers in Physiology - 2019 -
Potential roles of gut microbiome and metabolites in modulating ALS in
mice
E. Blacher, S. Bashiardes, H. Shapiro, D. Rothschild, U. Mor, M. Dori-Bachash, C. Kleimeyer, C. Moresi, Y. Harnik, M. Zur, M. Zabari, R. B. Z. Brik, D. Kviatcovsky, N. Zmora, Y. Cohen, N. Bar, I. Levi, N. Amar, T. Mehlman, A. Brandis, I. Biton, Y. Kuperman, M. Tsoory, L. Alfahel, A. Harmelin, M. Schwartz, A. Israelson, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, M. Gotkine, E. Segal, E. Elinav
Nature - 2019 -
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis
pathogenesis
Sjoerd van der Post, Karolina S. Jabbar, George M. H. Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjövall, Malin E V Johansson, Gunnar C. Hansson
Gut - 2019 -
Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing
properties
Elisabeth E. L. Nyström, Liisa Arike, Erik Ehrencrona, Gunnar C. Hansson, Malin E V Johansson
Journal of Biological Chemistry - 2019 -
Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic
Study
Karolina S. Jabbar, Liisa Arike, C. S. Verbeke, R. Sadik, Gunnar C. Hansson
Clinical Oncology - 2018 -
Attached stratified mucus separates bacteria from the epithelial cells in COPD
lungs
Dalia Fakih, Liisa Arike, Ana María Rodríguez-Piñeiro, Beatriz Martinez Abad, Elin Skansebo, S. Jackson, J. Root, D. Singh, Cristopher McCrae, C. M. Evans, A. Astrand, Anna Ermund, Gunnar C. Hansson
Jci Insight - 2018 -
Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus
Deterioration
Björn O. Schröder, George M. H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Cell Host & Microbe - 2018 -
Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic
Activity
Elisabeth E. L. Nyström, George M. H. Birchenough, Sjoerd van der Post, Liisa Arike, A. D. Gruber, Gunnar C. Hansson, Malin E V Johansson
Ebiomedicine - 2018 -
Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of
glycosyltranferases
Liisa Arike, Jessica Holmén Larsson, Gunnar C. Hansson
Glycobiology - 2017 -
The Densely O-Glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal
Bacteria.
Liisa Arike, Gunnar C. Hansson
Journal of molecular biology - 2016 -
Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial
Colonization
Malin E V Johansson, Hedvig E Jakobsson, Jessica Holmén Larsson, André Schütte, Anna Ermund, Ana María Rodríguez-Piñeiro, Liisa Arike, Catharina Wising, Frida Svensson, Fredrik Bäckhed, Gunnar C. Hansson
Cell Host & Microbe - 2015 -
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged
Mice
N. A. Erickson, Elisabeth E. L. Nyström, L. Mundhenk, Liisa Arike, R. Glauben, M. M. Heimesaat, A. Fischer, S. Bereswill, George M. H. Birchenough, A. D. Gruber, Malin E V Johansson
Plos One - 2015