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- Anna Ermund
Anna Ermund
Researcher
Department of Medical Biochemistry and Cell biology-
The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E2, while Cftr regulates de novo mucus release in response to
carbamylcholine
Penny L. Ljungholm, Anna Ermund, Molly M. Soderlund Garsveden, Victor Pettersson, Jenny K Gustafsson
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY - 2024 -
Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis
piglets
Ana Rodriguez-Piñeiro, Florian Jaudas, Nikolai Klymiuk, Andrea Bähr, Gunnar C. Hansson, Anna Ermund
Respiratory Research - 2023 -
Goblet cell interactions reorient bundled mucus strands for efficient airway
clearance
Meike F. Bos, Anna Ermund, Gunnar C. Hansson, Joost de Graaf
PNAS Nexus - 2023 -
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion
transport
Brendan Dolan, Anna Ermund, Beatriz Martinez Abad, M Johansson, Gunnar C. Hansson
Science Signaling - 2022 -
Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory
Granules.
Oanh N Hoang, Anna Ermund, Ana M Jaramillo, Dalia Fakih, Cory B French, Jose R Flores, Harry Karmouty-Quintana, Jesper Magnusson, Giorgio Fois, Michael Fauler, Manfred Frick, Peter Braubach, Joshua B Hales, Richard C Kurten, Reynold Panettieri, Leoncio Vergara, Camille Ehre, Roberto Adachi, Michael J Tuvim, Gunnar C. Hansson, Burton F Dickey
American journal of respiratory and critical care medicine - 2022 -
Mucus threads from surface goblet cells clear particles from the
airways
Anna Ermund, Lauren N Meiss, Brendan Dolan, F. Jaudas, Lars Ewaldsson, A. Bahr, N. Klymiuk, Gunnar C. Hansson
Respiratory Research - 2021 -
New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger
inhibition
Melania Giorgetti, N. Klymiuk, A. Bahr, M. Hemmerling, L. Jinton, R. Tarran, A. Malmgren, A. Astrand, Gunnar C. Hansson, Anna Ermund
European Journal of Pharmacology - 2021 -
Association between Brachyspira and irritable bowel syndrome with
diarrhoea
Karolina S. Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Åsa Johansson, Hans Törnblom, Magnus Simrén, Gunnar C. Hansson
Gut - 2021 -
Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b
mucin
Dalia Fakih, Ana Rodriguez-Piñeiro, Sergio Trillo-Muyo, C. M. Evans, Anna Ermund, Gunnar C. Hansson
American Journal of Physiology-Lung Cellular and Molecular Physiology - 2020 -
Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and
Microbiota
Liisa Arike, A. Seiman, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E V Johansson, Gunnar C. Hansson
Cell Reports - 2020 -
Extracellular ATP activates store-operated Ca2+ entry in white adipocytes: functional evidence for STIM1 and
ORAI1
Michael El Hachmane, Anna Ermund, Cecilia Brännmark, Charlotta S Olofsson
Biochemical Journal - 2018 -
Attached stratified mucus separates bacteria from the epithelial cells in COPD
lungs
Dalia Fakih, Liisa Arike, Ana María Rodríguez-Piñeiro, Beatriz Martinez Abad, Elin Skansebo, S. Jackson, J. Root, D. Singh, Cristopher McCrae, C. M. Evans, A. Astrand, Anna Ermund, Gunnar C. Hansson
Jci Insight - 2018 -
Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head
tetramers
Sergio Trillo-Muyo, Harriet E. Nilsson, Christian V Recktenwald, Anna Ermund, C. Ridley, Lauren N Meiss, A. Bahr, N. Klymiuk, Jeffrey J. Wine, P. J. B. Koeck, D. J. Thornton, H. Hebert, Gunnar C. Hansson
Journal of Biological Chemistry - 2018 -
Assembly, Release, and Transport of Airway Mucins in Pigs and
Humans
Anna Ermund, Sergio Trillo-Muyo, Gunnar C. Hansson
Annals of the American Thoracic Society - 2018 -
The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic
stimulation
Anna Ermund, Lauren N Meiss, Brendan Dolan, A. Bahr, N. Klymiuk, Gunnar C. Hansson
European Respiratory Journal - 2018 -
Progress in understanding mucus abnormalities in cystic fibrosis
airways
J. J. Wine, Gunnar C. Hansson, P. Konig, N. S. Joo, Anna Ermund, M. Pieper
Journal of Cystic Fibrosis - 2018 -
Mucus Detachment by Host Metalloprotease Meprin beta Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease
RgpB
R. Wichert, Anna Ermund, S. Schmidt, M. Schweinlin, M. Ksiazek, P. Arnold, K. Knittler, F. Wilkens, B. Potempa, B. Rabe, M. Stirnberg, R. Lucius, J. W. Bartsch, S. Nikolaus, M. Falk-Paulsen, P. Rosenstiel, M. Metzger, S. Rose-John, J. Potempa, Gunnar C. Hansson, P. J. Dempsey, C. Becker-Pauly
Cell Reports - 2017 -
OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating
calcium.
Anna Ermund, Christian V Recktenwald, Gudmund Skjåk-Braek, Lauren N Meiss, Edvar Onsøyen, Philip D Rye, Arne Dessen, Astrid Hilde Myrset, Gunnar C. Hansson
Clinical and experimental pharmacology & physiology - 2017 -
The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC
mucin
Anna Ermund, Lauren N Meiss, Ana María Rodríguez-Piñeiro, A. Bahr, Harriet E. Nilsson, Sergio Trillo-Muyo, C. Ridley, D. J. Thornton, J. J. Wine, H. Hebert, N. Klymiuk, Gunnar C. Hansson
Biochemical and Biophysical Research Communications - BBRC - 2017 -
Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein
ZG16.
Joakim H. Bergström, George M. H. Birchenough, Gergely Katona, Björn O. Schröder, André Schütte, Anna Ermund, Malin E V Johansson, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2016 -
The composition of the gut microbiota shapes the colon mucus
barrier.
Hedvig E Jakobsson, Ana María Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, Felix Sommer, Fredrik Bäckhed, Gunnar C. Hansson, Malin E V Johansson
EMBO reports - 2015 -
Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial
Colonization
Malin E V Johansson, Hedvig E Jakobsson, Jessica Holmén Larsson, André Schütte, Anna Ermund, Ana María Rodríguez-Piñeiro, Liisa Arike, Catharina Wising, Frida Svensson, Fredrik Bäckhed, Gunnar C. Hansson
Cell Host & Microbe - 2015 -
Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis
mucus
Anna Ermund, Lauren N Meiss, Jenny K Gustafsson, Gunnar C. Hansson
European Journal of Pharmacology - 2015 -
Hypertonic saline releases the attached small intestinal cystic fibrosis
mucus.
Anna Ermund, Lauren N Meiss, Bob J Scholte, Gunnar C. Hansson
Clinical and experimental pharmacology & physiology - 2015 -
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune
system
Thaher Pelaseyed, Joakim H. Bergström, Jenny K Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana María Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E V Johansson, Gunnar C. Hansson
Immunological Reviews - 2014 -
Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal
mucus
André Schütte, Anna Ermund, C. Becker-Pauly, Malin E V Johansson, Ana María Rodríguez-Piñeiro, Fredrik Bäckhed, S.C. Müller, D. Lottaz, J.S. Bond, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2014 -
Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in
enterocytes.
Thaher Pelaseyed, Jenny K Gustafsson, Ida J Gustafsson, Anna Ermund, Gunnar C. Hansson
American journal of physiology. Cell physiology - 2013 -
Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core
proteins.
Ana María Rodríguez-Piñeiro, Joakim H. Bergström, Anna Ermund, Jenny K Gustafsson, André Schütte, Malin E V Johansson, Gunnar C. Hansson
American journal of physiology. Gastrointestinal and liver physiology - 2013 -
Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's
patches.
Anna Ermund, André Schütte, Malin E V Johansson, Jenny K Gustafsson, Gunnar C. Hansson
American journal of physiology. Gastrointestinal and liver physiology - 2013 -
Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer's
patches.
Anna Ermund, Jenny K Gustafsson, Gunnar C. Hansson, Asa V Keita
PloS one - 2013 -
An ex vivo method for studying mucus formation, properties and thickness in human colonic biopsies and mouse small and large intestinal
explants.
Jenny K Gustafsson, Anna Ermund, Malin E V Johansson, André Schütte, Gunnar C. Hansson, Henrik Sjövall
American journal of physiology. Gastrointestinal and liver physiology - 2012 -
Perspectives on mucus properties and formation--lessons from the biochemical
world.
Daniel Ambort, Malin E V Johansson, Jenny K Gustafsson, Anna Ermund, Gunnar C. Hansson
Cold Spring Harbor perspectives in medicine - 2012 -
Calcium and pH-dependent packing and release of the gel-forming MUC2
mucin.
Daniel Ambort, Malin E V Johansson, Jenny K Gustafsson, Harriet E Nilsson, Anna Ermund, Bengt R Johansson, Philip J B Koeck, Hans Hebert, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2012 -
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus
phenotype.
Jenny K Gustafsson, Anna Ermund, Daniel Ambort, Malin E V Johansson, Harriet E Nilsson, Kaisa Thorell, Hans Hebert, Henrik Sjövall, Gunnar C. Hansson
The Journal of experimental medicine - 2012 -
Composition and functional role of the mucus layers in the
intestine.
Malin E V Johansson, Daniel Ambort, Thaher Pelaseyed, André Schütte, Jenny K Gustafsson, Anna Ermund, Durai B Subramani, Jessica Holmén Larsson, Kristina A Thomsson, Joakim H. Bergström, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Henrik Sjövall, Malin Bäckström, Gunnar C. Hansson
Cellular and Molecular Life Sciences - 2011