Gunnar C Hansson

• Adjunct mucin biomarkers MUC2+MUC5AC and MUC5AC+PSCA in a clinical setting identify and may improve correct selection of high-risk pancreatic lesions for surgery.

  Eva Philipson, Karolina S. Jabbar, Svein-Olav Bratlie, Gunnar C. Hansson, Jan Persson, Caroline Vilhav, Johanna Wennerblom, Riadh Sadik, Peter Naredi, Johan Bourghardt Fagman, Cecilia Engström
  HPB - 2025
• Structure of the MUC5AC VWD3 assembly responsible for the formation of net-like mucin polymers

  Sergio Trillo-Muyo, Anna Ermund, Gunnar C. Hansson
  EMBO REPORTS - 2025
• Mechanisms of uropathogenic <i>E. coli</i> mucosal association in the gastrointestinal tract

  Philippe N. Azimzadeh, George M. H. Birchenough, Nathaniel C. Gualbuerto, Jerome S. Pinkner, Kevin O. Tamadonfar, Wandy Beatty, Thomas J. Hannan, Karen W. Dodson, Enid C. Ibarra, Seonyoung Kim, Henry L. Schreiber, James W. Janetka, Andrew L. Kau, Ashlee M. Earl, Mark J. Miller, Gunnar C. Hansson, Scott J. Hultgren
  SCIENCE ADVANCES - 2025
• H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium

  Alison R. S. Pashos, Anne R. Meyer, Cameron Bussey-Sutton, Erin S. O'Connor, Mariel Coradin, Marilyne Coulombe, Kent A. Riemondy, Sanjana Potlapelly, Brian D. Strahl, Gunnar C. Hansson, Peter J. Dempsey, Justin Brumbaugh
  NATURE CELL BIOLOGY - 2025
• Immune Regulation of Goblet Cell and Mucus Functions in Health and Disease

  Jenny K Gustafsson, Gunnar C. Hansson
  ANNUAL REVIEW OF IMMUNOLOGY - 2025
• The structure of FCGBP is formed as a disulfide-mediated homodimer between its C-terminal domains

  Erik Ehrencrona, Pablo Gallego, Sergio Trillo-Muyo, Maria-Jose Garcia-Bonete, Christian V Recktenwald, Gunnar C. Hansson, Malin E V Johansson
  FEBS JOURNAL - 2025
• Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron

  Sadie R. Schaus, Gabriel Vasconcelos Pereira, Ana S. Luis, Emily Madlambayan, Nicolas Terrapon, Matthew P. Ostrowski, Chunsheng Jin, Bernard Henrissat, Gunnar C. Hansson, Eric C. Martens
  MBIO - 2024
• Metaproteomics reveals parallel utilization of colonic mucin glycans and dietary fibers by the human gut microbiota

  Grete Raba, Ana S. Luis, Hannah Schneider, Indrek Morell, Chunsheng Jin, Signe Adamberg, Gunnar C. Hansson, Kaarel Adamberg, Liisa Arike
  ISCIENCE - 2024
• GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota

  Thomas U. Greiner, Ara Koh, Eduard Peris, Mattias Bergentall, Malin E V Johansson, Gunnar C. Hansson, Daniel J. Drucker, Fredrik Bäckhed
  MOLECULAR METABOLISM - 2024
• The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based cross-linking

  Christian V Recktenwald, Göran Karlsson, Maria-Jose Garcia-Bonete, Gergely Katona, Maja Jensen, Richard Lymer, Malin Bäckström, Malin E V Johansson, Gunnar C. Hansson, Sergio Trillo-Muyo
  Cell Reports - 2024
• Goblet cell interactions reorient bundled mucus strands for efficient airway clearance

  Meike F. Bos, Anna Ermund, Gunnar C. Hansson, Joost de Graaf
  PNAS Nexus - 2023
• Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection

  George M. H. Birchenough, Björn O. Schröder, Sinan Sharba, Liisa Arike, Christian V Recktenwald, F. Puertolas-Balint, Mahadevan Subramani, Karl Hansson, B. Yilmaz, Sara K. Lindén, Fredrik Bäckhed, Gunnar C. Hansson
  Cell Reports - 2023
• Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons

  H. Arnesen, T. Markussen, George M. H. Birchenough, S. Birkeland, Elisabeth E. L. Nyström, Gunnar C. Hansson, H. Carlsen, P. Boysen
  Scientific Reports - 2023
• Mucus aberrant properties in CF: Insights from cells and animal models

  Camille Ehre, Gunnar C. Hansson, David J. Thornton, Lynda S. Ostedgaard
  Journal of Cystic Fibrosis - 2023
• The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins

  Pablo Gallego, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Christian V Recktenwald, Malin E V Johansson, Gunnar C. Hansson
  Nature communications - 2023
• Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis

  Cynthia Bülck, Elisabeth E.L. Nyström, Tomas Koudelka, Michael Mannbar-Frahm, Gerrit Andresen, Mariem Radhouani, Florian Tran, Franka Scharfenberg, Friederike Schrell, Fred Armbrust, Eileen Dahlke, Bei Zhao, Alex Vervaeke, Franziska Theilig, Philip Rosenstiel, Philipp Starkl, Stephan P. Rosshart, Helmut Fickenscher, Andreas Tholey, Gunnar C. Hansson, Christoph Becker-Pauly
  Science advances - 2023
• Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets

  Ana Rodriguez-Piñeiro, Florian Jaudas, Nikolai Klymiuk, Andrea Bähr, Gunnar C. Hansson, Anna Ermund
  Respiratory Research - 2023
• A Golgi oxygen sensor controls intestinal mucin glycosylation

  Gunnar C. Hansson
  EMBO Journal - 2023
• Intestinal mucus and their glycans: A habitat for thriving microbiota

  Ana S. Luis, Gunnar C. Hansson
  Cell Host & Microbe - 2023
• Goblet cells need some stress

  MEV Johansson, Gunnar C. Hansson
  Journal of Clinical Investigation - 2022
• Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport

  Brendan Dolan, Anna Ermund, Beatriz Martinez Abad, M Johansson, Gunnar C. Hansson
  Science Signaling - 2022
• Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.

  Oanh N Hoang, Anna Ermund, Ana M Jaramillo, Dalia Fakih, Cory B French, Jose R Flores, Harry Karmouty-Quintana, Jesper Magnusson, Giorgio Fois, Michael Fauler, Manfred Frick, Peter Braubach, Joshua B Hales, Richard C Kurten, Reynold Panettieri, Leoncio Vergara, Camille Ehre, Roberto Adachi, Michael J Tuvim, Gunnar C. Hansson, Burton F Dickey
  American journal of respiratory and critical care medicine - 2022
• Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota.

  Ana S. Luis, Arnaud Baslé, Dominic P Byrne, Gareth S A Wright, James A London, Chunsheng Jin, Niclas Karlsson, Gunnar C. Hansson, Patrick A Eyers, Mirjam Czjzek, Tristan Barbeyron, Edwin A Yates, Eric C Martens, Alan Cartmell
  Nature chemical biology - 2022
• Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer

  Jack D. A. Sharpen, Brendan Dolan, Elisabeth E. L. Nyström, George M. H. Birchenough, Liisa Arike, Beatriz Martinez Abad, Malin E V Johansson, Gunnar C. Hansson, Christian V Recktenwald
  Nature Communications - 2022
• Enterotoxigenic Escherichia coli Degrades the Host MUC2 Mucin Barrier To Facilitate Critical Pathogen-Enterocyte Interactions in Human Small Intestine

  A. Sheikh, T. Wangdi, T. J. Vickers, B. Aaron, M. Palmer, M. J. Miller, S. Kim, C. Herring, R. Simoes, J. A. Crainic, J. C. Gildersleeve, Sjoerd van der Post, Gunnar C. Hansson, J. M. Fleckenstein
  Infection and Immunity - 2022
• Mucus threads from surface goblet cells clear particles from the airways

  Anna Ermund, Lauren N Meiss, Brendan Dolan, F. Jaudas, Lars Ewaldsson, A. Bahr, N. Klymiuk, Gunnar C. Hansson
  Respiratory Research - 2021
• A single sulfatase is required to access colonic mucin by a gut bacterium

  Ana S. Luis, Chunsheng Jin, G. V. Pereira, R. W. P. Glowacki, S. R. Gugel, S. Singh, D. P. Byrne, N. A. Pudlo, J. A. London, A. Basle, M. Reihill, S. Oscarson, P. A. Eyers, M. Czjzek, G. Michel, T. Barbeyron, E. A. Yates, Gunnar C. Hansson, Niclas G. Karlsson, A. Cartmell, E. C. Martens
  Nature - 2021
• The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds

  Erik Ehrencrona, Sjoerd van der Post, Pablo Gallego, Christian V Recktenwald, Ana Rodriguez-Piñeiro, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Malin Bäckström, Gunnar C. Hansson, Malin E V Johansson
  Journal of Biological Chemistry - 2021
• New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition

  Melania Giorgetti, N. Klymiuk, A. Bahr, M. Hemmerling, L. Jinton, R. Tarran, A. Malmgren, A. Astrand, Gunnar C. Hansson, Anna Ermund
  European Journal of Pharmacology - 2021
• An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

  Elisabeth E. L. Nyström, Beatriz Martinez Abad, Liisa Arike, George M. H. Birchenough, E. B. Nonnecke, P. A. Castillo, Frida Svensson, C. L. Bevins, Gunnar C. Hansson, Malin E V Johansson
  Science - 2021
• Association between Brachyspira and irritable bowel syndrome with diarrhoea

  Karolina S. Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Åsa Johansson, Hans Törnblom, Magnus Simrén, Gunnar C. Hansson
  Gut - 2021
• Mucins and the Microbiome

  Gunnar C. Hansson
  Annual Review of Biochemistry - 2020
• Membrane mucins of the intestine at a glance

  Thaher Pelaseyed, Gunnar C. Hansson
  Journal of Cell Science - 2020
• Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin

  Dalia Fakih, Ana Rodriguez-Piñeiro, Sergio Trillo-Muyo, C. M. Evans, Anna Ermund, Gunnar C. Hansson
  American Journal of Physiology-Lung Cellular and Molecular Physiology - 2020
• Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota

  Liisa Arike, A. Seiman, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E V Johansson, Gunnar C. Hansson
  Cell Reports - 2020
• Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice

  Björn O. Schröder, George M. H. Birchenough, Meenakshi Pradhan, Elisabeth E. L. Nyström, Marcus Henricsson, Gunnar C. Hansson, Fredrik Bäckhed
  Journal of Biological Chemistry - 2020
• Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps

  Liisa Arike, Gunnar C. Hansson, Christian V Recktenwald
  Analytical Biochemistry - 2020
• The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function

  Joana K. Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz Martinez Abad, Björn O. Schröder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E V Johansson, Gunnar C. Hansson, George M. H. Birchenough
  Journal of Experimental Medicine - 2019
• The human transmembrane mucin MUC17 responds to TNF alpha by increased presentation at the plasma membrane

  Hannah Schneider, Evelin Berger, Brendan Dolan, Beatriz Martinez Abad, Liisa Arike, Thaher Pelaseyed, Gunnar C. Hansson
  Biochemical Journal - 2019
• Normal calcium-activated anion secretion in a mouse selectively lacking TMEM16A in intestinal epithelium

  Génesis Vega, Anita Guequén, Malin E V Johansson, Liisa Arike, Beatriz Martinez Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
  Frontiers in Physiology - 2019
• Potential roles of gut microbiome and metabolites in modulating ALS in mice

  E. Blacher, S. Bashiardes, H. Shapiro, D. Rothschild, U. Mor, M. Dori-Bachash, C. Kleimeyer, C. Moresi, Y. Harnik, M. Zur, M. Zabari, R. B. Z. Brik, D. Kviatcovsky, N. Zmora, Y. Cohen, N. Bar, I. Levi, N. Amar, T. Mehlman, A. Brandis, I. Biton, Y. Kuperman, M. Tsoory, L. Alfahel, A. Harmelin, M. Schwartz, A. Israelson, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, M. Gotkine, E. Segal, E. Elinav
  Nature - 2019
• Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract

  M. Furter, M. E. Sellin, Gunnar C. Hansson, W. D. Hardt
  Cell Reports - 2019
• Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier

  George M. H. Birchenough, Björn O. Schröder, Fredrik Bäckhed, Gunnar C. Hansson
  Gut microbes - 2019
• Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

  Sjoerd van der Post, Karolina S. Jabbar, George M. H. Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjövall, Malin E V Johansson, Gunnar C. Hansson
  Gut - 2019
• Mucus and mucins in diseases of the intestinal and respiratory tracts

  Gunnar C. Hansson
  Journal of Internal Medicine - 2019
• Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing properties

  Elisabeth E. L. Nyström, Liisa Arike, Erik Ehrencrona, Gunnar C. Hansson, Malin E V Johansson
  Journal of Biological Chemistry - 2019
• Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic Study

  Karolina S. Jabbar, Liisa Arike, C. S. Verbeke, R. Sadik, Gunnar C. Hansson
  Clinical Oncology - 2018
• Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs

  Dalia Fakih, Liisa Arike, Ana María Rodríguez-Piñeiro, Beatriz Martinez Abad, Elin Skansebo, S. Jackson, J. Root, D. Singh, Cristopher McCrae, C. M. Evans, A. Astrand, Anna Ermund, Gunnar C. Hansson
  Jci Insight - 2018
• Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers

  Sergio Trillo-Muyo, Harriet E. Nilsson, Christian V Recktenwald, Anna Ermund, C. Ridley, Lauren N Meiss, A. Bahr, N. Klymiuk, Jeffrey J. Wine, P. J. B. Koeck, D. J. Thornton, H. Hebert, Gunnar C. Hansson
  Journal of Biological Chemistry - 2018
• Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

  Björn O. Schröder, George M. H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, Fredrik Bäckhed
  Cell Host & Microbe - 2018

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