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Gunnar C Hansson
Seniorforskare
Department of Medical Biochemistry and Cell-
Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen
infection
George M. H. Birchenough, Björn O. Schröder, Sinan Sharba, Liisa Arike, Christian V Recktenwald, F. Puertolas-Balint, Mahadevan Subramani, Karl Hansson, B. Yilmaz, Sara K. Lindén, Fredrik Bäckhed, Gunnar C. Hansson
Cell Reports - 2023 -
Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse
colons
H. Arnesen, T. Markussen, George M. H. Birchenough, S. Birkeland, Elisabeth E. L. Nyström, Gunnar C. Hansson, H. Carlsen, P. Boysen
Scientific Reports - 2023 -
Mucus aberrant properties in CF: Insights from cells and animal
models
Camille Ehre, Gunnar C. Hansson, David J. Thornton, Lynda S. Ostedgaard
Journal of Cystic Fibrosis - 2023 -
The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming
mucins
Pablo Gallego, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Christian V Recktenwald, Malin E V Johansson, Gunnar C. Hansson
Nature communications - 2023 -
Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome
homeostasis
Cynthia Bülck, Elisabeth E.L. Nyström, Tomas Koudelka, Michael Mannbar-Frahm, Gerrit Andresen, Mariem Radhouani, Florian Tran, Franka Scharfenberg, Friederike Schrell, Fred Armbrust, Eileen Dahlke, Bei Zhao, Alex Vervaeke, Franziska Theilig, Philip Rosenstiel, Philipp Starkl, Stephan P. Rosshart, Helmut Fickenscher, Andreas Tholey, Gunnar C. Hansson, Christoph Becker-Pauly
Science advances - 2023 -
Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis
piglets
Ana Rodriguez-Piñeiro, Florian Jaudas, Nikolai Klymiuk, Andrea Bähr, Gunnar C. Hansson, Anna Ermund
Respiratory Research - 2023 -
A Golgi oxygen sensor controls intestinal mucin
glycosylation
Gunnar C. Hansson
EMBO Journal - 2023 -
Goblet cell interactions reorient bundled mucus strands for efficient airway
clearance
Meike F. Bos, Anna Ermund, Gunnar C. Hansson, Joost de Graaf
PNAS Nexus - 2023 -
Intestinal mucus and their glycans: A habitat for thriving
microbiota
Ana S. Luis, Gunnar C. Hansson
Cell Host & Microbe - 2023 -
Goblet cells need some
stress
MEV Johansson, Gunnar C. Hansson
Journal of Clinical Investigation - 2022 -
Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion
transport
Brendan Dolan, Anna Ermund, Beatriz Martinez Abad, M Johansson, Gunnar C. Hansson
Science Signaling - 2022 -
Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory
Granules.
Oanh N Hoang, Anna Ermund, Ana M Jaramillo, Dalia Fakih, Cory B French, Jose R Flores, Harry Karmouty-Quintana, Jesper Magnusson, Giorgio Fois, Michael Fauler, Manfred Frick, Peter Braubach, Joshua B Hales, Richard C Kurten, Reynold Panettieri, Leoncio Vergara, Camille Ehre, Roberto Adachi, Michael J Tuvim, Gunnar C. Hansson, Burton F Dickey
American journal of respiratory and critical care medicine - 2022 -
Sulfated glycan recognition by carbohydrate sulfatases of the human gut
microbiota.
Ana S. Luis, Arnaud Baslé, Dominic P Byrne, Gareth S A Wright, James A London, Chunsheng Jin, Niclas Karlsson, Gunnar C. Hansson, Patrick A Eyers, Mirjam Czjzek, Tristan Barbeyron, Edwin A Yates, Eric C Martens, Alan Cartmell
Nature chemical biology - 2022 -
Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus
layer
Jack D. A. Sharpen, Brendan Dolan, Elisabeth E. L. Nyström, George M. H. Birchenough, Liisa Arike, Beatriz Martinez Abad, Malin E V Johansson, Gunnar C. Hansson, Christian V Recktenwald
Nature Communications - 2022 -
Enterotoxigenic Escherichia coli Degrades the Host MUC2 Mucin Barrier To Facilitate Critical Pathogen-Enterocyte Interactions in Human Small
Intestine
A. Sheikh, T. Wangdi, T. J. Vickers, B. Aaron, M. Palmer, M. J. Miller, S. Kim, C. Herring, R. Simoes, J. A. Crainic, J. C. Gildersleeve, Sjoerd van der Post, Gunnar C. Hansson, J. M. Fleckenstein
Infection and Immunity - 2022 -
Mucus threads from surface goblet cells clear particles from the
airways
Anna Ermund, Lauren N Meiss, Brendan Dolan, F. Jaudas, Lars Ewaldsson, A. Bahr, N. Klymiuk, Gunnar C. Hansson
Respiratory Research - 2021 -
A single sulfatase is required to access colonic mucin by a gut
bacterium
Ana S. Luis, Chunsheng Jin, G. V. Pereira, R. W. P. Glowacki, S. R. Gugel, S. Singh, D. P. Byrne, N. A. Pudlo, J. A. London, A. Basle, M. Reihill, S. Oscarson, P. A. Eyers, M. Czjzek, G. Michel, T. Barbeyron, E. A. Yates, Gunnar C. Hansson, Niclas G. Karlsson, A. Cartmell, E. C. Martens
Nature - 2021 -
The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide
bonds
Erik Ehrencrona, Sjoerd van der Post, Pablo Gallego, Christian V Recktenwald, Ana Rodriguez-Piñeiro, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Malin Bäckström, Gunnar C. Hansson, Malin E V Johansson
Journal of Biological Chemistry - 2021 -
New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger
inhibition
Melania Giorgetti, N. Klymiuk, A. Bahr, M. Hemmerling, L. Jinton, R. Tarran, A. Malmgren, A. Astrand, Gunnar C. Hansson, Anna Ermund
European Journal of Pharmacology - 2021 -
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier
function
Elisabeth E. L. Nyström, Beatriz Martinez Abad, Liisa Arike, George M. H. Birchenough, E. B. Nonnecke, P. A. Castillo, Frida Svensson, C. L. Bevins, Gunnar C. Hansson, Malin E V Johansson
Science - 2021 -
Association between Brachyspira and irritable bowel syndrome with
diarrhoea
Karolina S. Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Åsa Johansson, Hans Törnblom, Magnus Simrén, Gunnar C. Hansson
Gut - 2021 -
Mucins and the
Microbiome
Gunnar C. Hansson
Annual Review of Biochemistry - 2020 -
Membrane mucins of the intestine at a
glance
Thaher Pelaseyed, Gunnar C. Hansson
Journal of Cell Science - 2020 -
Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b
mucin
Dalia Fakih, Ana Rodriguez-Piñeiro, Sergio Trillo-Muyo, C. M. Evans, Anna Ermund, Gunnar C. Hansson
American Journal of Physiology-Lung Cellular and Molecular Physiology - 2020 -
Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and
Microbiota
Liisa Arike, A. Seiman, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Anna Ermund, André Schütte, Fredrik Bäckhed, Malin E V Johansson, Gunnar C. Hansson
Cell Reports - 2020 -
Obesity-associated microbiota contributes to mucus layer defects in genetically obese
mice
Björn O. Schröder, George M. H. Birchenough, Meenakshi Pradhan, Elisabeth E. L. Nyström, Marcus Henricsson, Gunnar C. Hansson, Fredrik Bäckhed
Journal of Biological Chemistry - 2020 -
Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and
traps
Liisa Arike, Gunnar C. Hansson, Christian V Recktenwald
Analytical Biochemistry - 2020 -
The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or
function
Joana K. Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz Martinez Abad, Björn O. Schröder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E V Johansson, Gunnar C. Hansson, George M. H. Birchenough
Journal of Experimental Medicine - 2019 -
The human transmembrane mucin MUC17 responds to TNF alpha by increased presentation at the plasma
membrane
Hannah Schneider, Evelin Berger, Brendan Dolan, Beatriz Martinez Abad, Liisa Arike, Thaher Pelaseyed, Gunnar C. Hansson
Biochemical Journal - 2019 -
Normal calcium-activated anion secretion in a mouse selectively lacking TMEM16A in intestinal
epithelium
Génesis Vega, Anita Guequén, Malin E V Johansson, Liisa Arike, Beatriz Martinez Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Frontiers in Physiology - 2019 -
Potential roles of gut microbiome and metabolites in modulating ALS in
mice
E. Blacher, S. Bashiardes, H. Shapiro, D. Rothschild, U. Mor, M. Dori-Bachash, C. Kleimeyer, C. Moresi, Y. Harnik, M. Zur, M. Zabari, R. B. Z. Brik, D. Kviatcovsky, N. Zmora, Y. Cohen, N. Bar, I. Levi, N. Amar, T. Mehlman, A. Brandis, I. Biton, Y. Kuperman, M. Tsoory, L. Alfahel, A. Harmelin, M. Schwartz, A. Israelson, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, M. Gotkine, E. Segal, E. Elinav
Nature - 2019 -
Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal
Tract
M. Furter, M. E. Sellin, Gunnar C. Hansson, W. D. Hardt
Cell Reports - 2019 -
Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis
pathogenesis
Sjoerd van der Post, Karolina S. Jabbar, George M. H. Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjövall, Malin E V Johansson, Gunnar C. Hansson
Gut - 2019 -
Mucus and mucins in diseases of the intestinal and respiratory
tracts
Gunnar C. Hansson
Journal of Internal Medicine - 2019 -
Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2-processing
properties
Elisabeth E. L. Nyström, Liisa Arike, Erik Ehrencrona, Gunnar C. Hansson, Malin E V Johansson
Journal of Biological Chemistry - 2019 -
Dietary destabilisation of the balance between the microbiota and the colonic mucus
barrier
George M. H. Birchenough, Björn O. Schröder, Fredrik Bäckhed, Gunnar C. Hansson
Gut microbes - 2019 -
Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic
Study
Karolina S. Jabbar, Liisa Arike, C. S. Verbeke, R. Sadik, Gunnar C. Hansson
Clinical Oncology - 2018 -
Attached stratified mucus separates bacteria from the epithelial cells in COPD
lungs
Dalia Fakih, Liisa Arike, Ana María Rodríguez-Piñeiro, Beatriz Martinez Abad, Elin Skansebo, S. Jackson, J. Root, D. Singh, Cristopher McCrae, C. M. Evans, A. Astrand, Anna Ermund, Gunnar C. Hansson
Jci Insight - 2018 -
Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head
tetramers
Sergio Trillo-Muyo, Harriet E. Nilsson, Christian V Recktenwald, Anna Ermund, C. Ridley, Lauren N Meiss, A. Bahr, N. Klymiuk, Jeffrey J. Wine, P. J. B. Koeck, D. J. Thornton, H. Hebert, Gunnar C. Hansson
Journal of Biological Chemistry - 2018 -
Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus
Deterioration
Björn O. Schröder, George M. H. Birchenough, Marcus Ståhlman, Liisa Arike, Malin E V Johansson, Gunnar C. Hansson, Fredrik Bäckhed
Cell Host & Microbe - 2018 -
The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between
individuals
Frida Svensson, T. G. Lang, Malin E V Johansson, Gunnar C. Hansson
Scientific Reports - 2018 -
Assembly, Release, and Transport of Airway Mucins in Pigs and
Humans
Anna Ermund, Sergio Trillo-Muyo, Gunnar C. Hansson
Annals of the American Thoracic Society - 2018 -
The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic
stimulation
Anna Ermund, Lauren N Meiss, Brendan Dolan, A. Bahr, N. Klymiuk, Gunnar C. Hansson
European Respiratory Journal - 2018 -
Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic
Activity
Elisabeth E. L. Nyström, George M. H. Birchenough, Sjoerd van der Post, Liisa Arike, A. D. Gruber, Gunnar C. Hansson, Malin E V Johansson
Ebiomedicine - 2018 -
Progress in understanding mucus abnormalities in cystic fibrosis
airways
J. J. Wine, Gunnar C. Hansson, P. Konig, N. S. Joo, Anna Ermund, M. Pieper
Journal of Cystic Fibrosis - 2018 -
Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of
glycosyltranferases
Liisa Arike, Jessica Holmén Larsson, Gunnar C. Hansson
Glycobiology - 2017 -
Mucus Detachment by Host Metalloprotease Meprin beta Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease
RgpB
R. Wichert, Anna Ermund, S. Schmidt, M. Schweinlin, M. Ksiazek, P. Arnold, K. Knittler, F. Wilkens, B. Potempa, B. Rabe, M. Stirnberg, R. Lucius, J. W. Bartsch, S. Nikolaus, M. Falk-Paulsen, P. Rosenstiel, M. Metzger, S. Rose-John, J. Potempa, Gunnar C. Hansson, P. J. Dempsey, C. Becker-Pauly
Cell Reports - 2017 -
OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating
calcium.
Anna Ermund, Christian V Recktenwald, Gudmund Skjåk-Braek, Lauren N Meiss, Edvar Onsøyen, Philip D Rye, Arne Dessen, Astrid Hilde Myrset, Gunnar C. Hansson
Clinical and experimental pharmacology & physiology - 2017 -
Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in
mice.
K Bergstrom, J Fu, Malin E V Johansson, X Liu, N Gao, Q Wu, J Song, J M McDaniel, S McGee, W Chen, J Braun, Gunnar C. Hansson, L Xia
Mucosal immunology - 2017 -
Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1
infection
George M. H. Birchenough, F. Dalgakiran, L. A. Witcomb, Malin E V Johansson, A. J. McCarthy, Gunnar C. Hansson, P. W. Taylor
Scientific Reports - 2017 -
The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC
mucin
Anna Ermund, Lauren N Meiss, Ana María Rodríguez-Piñeiro, A. Bahr, Harriet E. Nilsson, Sergio Trillo-Muyo, C. Ridley, D. J. Thornton, J. J. Wine, H. Hebert, N. Klymiuk, Gunnar C. Hansson
Biochemical and Biophysical Research Communications - BBRC - 2017 -
Functional mucous layer and healing of proximal colonic anastomoses in an experimental
model.
J W A M Bosmans, A C H M Jongen, George M. H. Birchenough, Elisabeth E. L. Nyström, M J J Gijbels, J P M Derikx, N D Bouvy, Gunnar C. Hansson
The British journal of surgery - 2017 -
Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein
ZG16.
Joakim H. Bergström, George M. H. Birchenough, Gergely Katona, Björn O. Schröder, André Schütte, Anna Ermund, Malin E V Johansson, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2016 -
Searching the Evolutionary Origin of Epithelial Mucus Protein Components-Mucins and
FCGBP
Tiange Lang, Sofia Klasson, Erik Larsson, Malin E V Johansson, Gunnar C. Hansson, Tore Samuelsson
Molecular Biology and Evolution - 2016 -
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2
secretion
George M. H. Birchenough, Elisabeth E. L. Nyström, Malin E V Johansson, Gunnar C. Hansson
Science - 2016 -
The
Mucins
Malin E V Johansson, Gunnar C. Hansson
Encyclopedia of Immunobiology - 2016 -
Immunological aspects of intestinal mucus and
mucins
Malin E V Johansson, Gunnar C. Hansson
Nature Reviews Immunology - 2016 -
The Densely O-Glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal
Bacteria.
Liisa Arike, Gunnar C. Hansson
Journal of molecular biology - 2016 -
The reduction-insensitive bonds of the MUC2 mucin are isopeptide
bonds.
Christian V Recktenwald, Gunnar C. Hansson
The Journal of biological chemistry - 2016 -
Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane
Vesicles
C. A. Hickey, K. A. Kuhn, D. L. Donermeyer, N. T. Porter, Chunsheng Jin, E. A. Cameron, H. Jung, G. E. Kaiko, M. Wegorzewska, N. P. Malvin, R. W. P. Glowacki, Gunnar C. Hansson, P. M. Allen, E. C. Martens, T. S. Stappenbeck
Cell Host & Microbe - 2015 -
The composition of the gut microbiota shapes the colon mucus
barrier.
Hedvig E Jakobsson, Ana María Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, Felix Sommer, Fredrik Bäckhed, Gunnar C. Hansson, Malin E V Johansson
EMBO reports - 2015 -
Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial
Colonization
Malin E V Johansson, Hedvig E Jakobsson, Jessica Holmén Larsson, André Schütte, Anna Ermund, Ana María Rodríguez-Piñeiro, Liisa Arike, Catharina Wising, Frida Svensson, Fredrik Bäckhed, Gunnar C. Hansson
Cell Host & Microbe - 2015 -
Quantitative Imaging of Gut Microbiota Spatial
Organization
K. A. Earle, G. Billings, M. Sigal, J. S. Lichtman, Gunnar C. Hansson, J. E. Elias, M. R. Amieva, K. C. Huang, J. L. Sonnenburg
Cell Host and Microbe - 2015 -
Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis
mucus
Anna Ermund, Lauren N Meiss, Jenny K Gustafsson, Gunnar C. Hansson
European Journal of Pharmacology - 2015 -
CD103(+)CD11b(+) Dendritic Cells Induce T(h)17 T Cells in Muc2-Deficient Mice with Extensively Spread
Colitis
Ulf Alexander Wenzel, Caroline Jonstrand, Gunnar C. Hansson, Mary Jo Wick
Plos One - 2015 -
New developments in goblet cell mucus secretion and
function
George M. H. Birchenough, Malin E V Johansson, Jenny K Gustafsson, Joakim H. Bergström, Gunnar C. Hansson
Mucosal Immunology - 2015 -
Carbachol-induced colonic mucus formation requires transport via NKCC1, K(+) channels and
CFTR.
Jenny K Gustafsson, Sara K. Lindén, Ala H Alwan, Bob J Scholte, Gunnar C. Hansson, Henrik Sjövall
Pflugers Archiv : European journal of physiology - 2015 -
Hypertonic saline releases the attached small intestinal cystic fibrosis
mucus.
Anna Ermund, Lauren N Meiss, Bob J Scholte, Gunnar C. Hansson
Clinical and experimental pharmacology & physiology - 2015 -
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative
colitis.
Malin E V Johansson, Jenny K Gustafsson, Jessica Holmén Larsson, Karolina S. Jabbar, Lijun Xia, Hua Xu, Fayez K Ghishan, Frederic A Carvalho, Andrew T Gewirtz, Henrik Sjövall, Gunnar C. Hansson
Gut - 2014 -
Response.
Karolina S. Jabbar, Caroline Verbeke, Anders Hyltander, Henrik Sjövall, Gunnar C. Hansson, Riadh Sadik
Journal of the National Cancer Institute - 2014 -
Proteomic Mucin Profiling for the Identification of Cystic Precursors of Pancreatic
Cancer
Karolina S. Jabbar, C. Verbeke, Anders Hyltander, H. Sjovall, Gunnar C. Hansson, R. Sadik
Jnci-Journal of the National Cancer Institute - 2014 -
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune
system
Thaher Pelaseyed, Joakim H. Bergström, Jenny K Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana María Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E V Johansson, Gunnar C. Hansson
Immunological Reviews - 2014 -
Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal
architecture.
Felix Sommer, Nina Adam, Malin E V Johansson, Lijun Xia, Gunnar C. Hansson, Fredrik Bäckhed
PloS one - 2014 -
Inhibition of cyclooxygenase-2 prevents chronic and recurrent
cystitis
T. J. Hannan, P. L. Roberts, T. E. Riehl, Sjoerd van der Post, J. M. Binkley, D. J. Schwartz, H. Miyoshi, M. Mack, R. A. Schwendener, T. M. Hooton, T. S. Stappenbeck, Gunnar C. Hansson, W. F. Stenson, M. Colonna, A. E. Stapleton, S. J. Hultgren
EBioMedicine - 2014 -
Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain
assembly.
Harriet E. Nilsson, Daniel Ambort, Malin Bäckström, Elisabeth Thomsson, Philip J B Koeck, Gunnar C. Hansson, Hans Hebert
Journal of molecular biology - 2014 -
Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative
colitis.
Ulf Alexander Wenzel, Maria K Magnusson, Anna Rydström, Caroline Jonstrand, Julia Hengst, Malin E V Johansson, Anna Velcich, Lena Öhman, Hans Strid, Henrik Sjövall, Gunnar C. Hansson, Mary Jo Wick
PloS one - 2014 -
Is the intestinal goblet cell a major immune
cell?
Malin E V Johansson, Gunnar C. Hansson
Cell host & microbe - 2014 -
Modified-chitosan/siRNA nanoparticles downregulate cellular CDX2 expression and cross the gastric mucus
barrier.
Ana Sadio, Jenny K Gustafsson, Bruno Pereira, Carla Pereira Gomes, Gunnar C. Hansson, Leonor David, Ana Paula Pêgo, Raquel Almeida
PloS one - 2014 -
AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal
mucus.
Joakim H. Bergström, Katarina A Berg, Ana María Rodríguez-Piñeiro, Bärbel Stecher, Malin E V Johansson, Gunnar C. Hansson
PloS one - 2014 -
Multiple Enzyme Approach for the Characterization of Glycan Modifications on the C-Terminus of the Intestinal
MUC2Mucin.
Sjoerd van der Post, Kristina A Thomsson, Gunnar C. Hansson
Journal of proteome research - 2014 -
Membrane Protein Profiling of Human Colon Reveals Distinct Regional
Differences
Sjoerd van der Post, Gunnar C. Hansson
Molecular & Cellular Proteomics - 2014 -
Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal
mucus
André Schütte, Anna Ermund, C. Becker-Pauly, Malin E V Johansson, Ana María Rodríguez-Piñeiro, Fredrik Bäckhed, S.C. Müller, D. Lottaz, J.S. Bond, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2014 -
Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer, and barrier impairment in
mice.
Fang Xiao, Qin Yu, Junhua Li, Malin E V Johansson, Anurag Kumar Singh, Weiliang Xia, Brigitte Riederer, Regina Engelhardt, Marshall Montrose, Manoocher Soleimani, De-An Tian, Gang Xu, Gunnar C. Hansson, Ursula Seidler
Acta physiologica (Oxford, England) - 2014 -
Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease
(RgpB).
Sjoerd van der Post, Durai B Subramani, Malin Bäckström, Malin E V Johansson, Malene B Vester-Christensen, Ulla Mandel, Eric P Bennett, Henrik Clausen, Gunnar Dahlén, Aneta Sroka, Jan Potempa, Gunnar C. Hansson
The Journal of biological chemistry - 2013 -
Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia
coli.
George M. H. Birchenough, Malin E V Johansson, Richard A Stabler, Fatma Dalgakiran, Gunnar C. Hansson, Brendan W Wren, J Paul Luzio, Peter W Taylor
Infection and immunity - 2013 -
Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia
coli
George M. H. Birchenough, Malin E V Johansson, R. A. Stabler, F. Dalgakiran, Gunnar C. Hansson, B. W. Wren, J. P. Luzio, P. W. Taylor
Infection and Immunity - 2013 -
Dynamic changes in mucus thickness and ion secretion during Citrobacter rodentium infection and
clearance.
Jenny K Gustafsson, Nazanin Navabi, Ana María Rodríguez-Piñeiro, Ala Alomran, Pushpa Premaratne, Harvey Robert Fernandez, Debashish Banerjee, Henrik Sjövall, Gunnar C. Hansson, Sara K. Lindén
PloS one - 2013 -
Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in
enterocytes.
Thaher Pelaseyed, Jenny K Gustafsson, Ida J Gustafsson, Anna Ermund, Gunnar C. Hansson
American journal of physiology. Cell physiology - 2013 -
Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core
proteins.
Ana María Rodríguez-Piñeiro, Joakim H. Bergström, Anna Ermund, Jenny K Gustafsson, André Schütte, Malin E V Johansson, Gunnar C. Hansson
American journal of physiology. Gastrointestinal and liver physiology - 2013 -
Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's
patches.
Anna Ermund, André Schütte, Malin E V Johansson, Jenny K Gustafsson, Gunnar C. Hansson
American journal of physiology. Gastrointestinal and liver physiology - 2013 -
Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer's
patches.
Anna Ermund, Jenny K Gustafsson, Gunnar C. Hansson, Asa V Keita
PloS one - 2013 -
Mucus and the Goblet
Cell
Malin E V Johansson, Gunnar C. Hansson
Digestive Diseases - 2013 -
Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific
distribution
Jessica Holmén Larsson, Kristina A Thomsson, Ana María Rodríguez-Piñeiro, Hasse Karlsson, Gunnar C. Hansson
American Journal of Physiology-Gastrointestinal and Liver Physiology - 2013 -
The gastrointestinal mucus system in health and
disease.
Malin E V Johansson, Henrik Sjövall, Gunnar C. Hansson
Nature reviews. Gastroenterology & hepatology - 2013 -
NHE8 plays an important role in mucosal protection via its effect on bacterial
adhesion.
Chang Liu, Hua Xu, Bo Zhang, Malin E V Johansson, Jing Li, Gunnar C. Hansson, Fayez K Ghishan
American journal of physiology. Cell physiology - 2013 -
Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein
domains.
Malin Bäckström, Daniel Ambort, Elisabeth Thomsson, Malin E V Johansson, Gunnar C. Hansson
Molecular biotechnology - 2013 -
Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective
device.
Thaher Pelaseyed, Michael Zäch, Asa C Petersson, Frida Svensson, Denny G A Johansson, Gunnar C. Hansson
The FEBS journal - 2013 -
The goblet cell: a key player in ischaemia-reperfusion
injury.
Malin E V Johansson, Gunnar C. Hansson
Gut - 2013 -
Ulcerative colitis patients in remission have an altered secretory capacity in the proximal colon despite macroscopically normal
mucosa
Jenny K Gustafsson, Gunnar C. Hansson, Henrik Sjövall
Neurogastroenterology and Motility - 2012 -
An ex vivo method for studying mucus formation, properties and thickness in human colonic biopsies and mouse small and large intestinal
explants.
Jenny K Gustafsson, Anna Ermund, Malin E V Johansson, André Schütte, Gunnar C. Hansson, Henrik Sjövall
American journal of physiology. Gastrointestinal and liver physiology - 2012 -
Analysis of assembly of secreted
mucins
Malin E V Johansson, Gunnar C. Hansson
Methods in Molecular Biology - 2012 -
Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human
individual.
Michael Breimer, Gunnar C. Hansson, Karl-Anders Karlsson, Göran Larson, Hakon Leffler
Glycobiology - 2012 -
Preservation of mucus in histological sections, immunostaining of mucins in fixed tissue, and localization of bacteria with
FISH.
Malin E V Johansson, Gunnar C. Hansson
Methods in molecular biology (Clifton, N.J.) - 2012 -
Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse
colon.
Maria Arampatzidou, André Schütte, Gunnar C. Hansson, Paul Saftig, Klaudia Brix
Biological chemistry - 2012 -
Perspectives on mucus properties and formation--lessons from the biochemical
world.
Daniel Ambort, Malin E V Johansson, Jenny K Gustafsson, Anna Ermund, Gunnar C. Hansson
Cold Spring Harbor perspectives in medicine - 2012 -
Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human
MUC2.
Kristina A Thomsson, Jessica Holmén, Jonas Ångström, Malin E V Johansson, Lijun Xia, Gunnar C. Hansson
Glycobiology - 2012 -
Ex vivo measurements of mucus secretion by colon
explants.
Jenny K Gustafsson, Henrik Sjövall, Gunnar C. Hansson
Methods in Molecular Biology - 2012 -
Role of mucus layers in gut infection and
inflammation.
Gunnar C. Hansson
Current opinion in microbiology - 2012 -
Proteomic study of the mucin granulae in an intestinal goblet cell
model.
Ana María Rodríguez-Piñeiro, Sjoerd van der Post, Malin E V Johansson, Kristina A Thomsson, Alexey I Nesvizhskii, Gunnar C. Hansson
Journal of proteome research - 2012 -
Calcium and pH-dependent packing and release of the gel-forming MUC2
mucin.
Daniel Ambort, Malin E V Johansson, Jenny K Gustafsson, Harriet E Nilsson, Anna Ermund, Bengt R Johansson, Philip J B Koeck, Hans Hebert, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2012 -
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus
phenotype.
Jenny K Gustafsson, Anna Ermund, Daniel Ambort, Malin E V Johansson, Harriet E Nilsson, Kaisa Thorell, Hans Hebert, Henrik Sjövall, Gunnar C. Hansson
The Journal of experimental medicine - 2012 -
Composition and functional role of the mucus layers in the
intestine.
Malin E V Johansson, Daniel Ambort, Thaher Pelaseyed, André Schütte, Jenny K Gustafsson, Anna Ermund, Durai B Subramani, Jessica Holmén Larsson, Kristina A Thomsson, Joakim H. Bergström, Sjoerd van der Post, Ana María Rodríguez-Piñeiro, Henrik Sjövall, Malin Bäckström, Gunnar C. Hansson
Cellular and Molecular Life Sciences - 2011 -
CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein
GOPC.
Thaher Pelaseyed, Gunnar C. Hansson
Journal of cell science - 2011 -
Microbiology. Keeping bacteria at a
distance.
Malin E V Johansson, Gunnar C. Hansson
Science (New York, N.Y.) - 2011 -
Stromal IFN-gamma R-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium
Infection
P Songhet, M Barthel, B Stecher, AJ Muller, M Kremer, Gunnar C. Hansson, WD Hardt
PLOS ONE - 2011 -
Function of the CysD domain of the gel-forming MUC2
mucin.
Daniel Ambort, Sjoerd van der Post, Malin E V Johansson, J. Mackenzie, Elisabeth Thomsson, Ute Krengel, Gunnar C. Hansson
Biochem Journal - 2011 -
Keeping Bacteria at a
Distance
Malin E V Johansson, Gunnar C. Hansson
Science - 2011 -
Stromal IFN-γR-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium
Infection
P. Songhet, M. Barthel, B. Stecher, A.J. Muller, M. Kremer, Gunnar C. Hansson, W.D. Hardt
PLoS One - 2011 -
Identification and quantification of mucin
expression.
Kristina A Thomsson, Gunnar C. Hansson
Methods Mol. Biol. - 2011 -
Recombinant glycoprotein E produced in mammalian cells in large-scale as an antigen for
varicella-zoster-virus-serology.
Elisabeth Thomsson, L. Persson, Ammi Grahn, Johanna Snäll, Maria Ekblad, Eva Brunhage, Frida Svensson, Gunnar C. Hansson, Malin Bäckström, Tomas Bergström
J. Virol. Methods - 2011 -
O-glycosylation of MUC1 mucin in prostate cancer and the effects of its expression on tumor growth in a prostate cancer xenograft
model.
Pushpa Premaratne, Karin Welén, Jan-Erik Damber, Gunnar C. Hansson, Malin Bäckström
Tumor Biol. - 2011 -
The two mucus layers of colon are organized by the MUC2 mucin – the outer layer is a legislator of host-microbial
interactions.
Malin E V Johansson, Jessica Holmén Larsson, Gunnar C. Hansson
Proc. Natl. Acad. Sci. USA - 2011 -
An Altered O-glycosylation Profile of the MUC2 Mucin Occurs in Active Ulcerative Colitis and is Associated with Increased
Inflammation.
Jessica Holmén Larsson, Hasse Karlsson, Jessica Gråberg Crespo, Malin E V Johansson, Lisbeth Eklund, Henrik Sjövall, Gunnar C. Hansson
Infl. Bowel Dis. - 2011 -
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial
interactions.
Malin E V Johansson, Jessica Holmén Larsson, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2011 -
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased
inflammation.
Jessica Holmén Larsson, Hasse Karlsson, Jessica Gråberg Crespo, Malin E V Johansson, Lisbeth Eklund, Henrik Sjövall, Gunnar C. Hansson
Inflammatory bowel diseases - 2011 -
Identification and quantification of mucin
expression
Kristina A Thomsson, Gunnar C. Hansson
Methods in molecular biology (Clifton, N.J.) - 2011 -
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in
mice.
Jianxin Fu, Bo Wei, Tao Wen, Malin E V Johansson, Xiaowei Liu, Emily Bradford, Kristina A Thomsson, Samuel McGee, Lilah Mansour, Maomeng Tong, J Michael McDaniel, Thomas J Sferra, Jerrold R Turner, Hong Chen, Gunnar C. Hansson, Jonathan Braun, Lijun Xia
The Journal of clinical investigation - 2011 -
Recombinant glycoprotein E produced in mammalian cells in large-scale as an antigen for varicella-zoster-virus
serology.
Elisabeth Thomsson, Linn Persson, Anna Grahn, Johanna Snäll, Maria Ekblad, Eva Brunhage, Frida Svensson, Christina Jern, Gunnar C. Hansson, Malin Bäckström, Tomas Bergström
Journal of virological methods - 2011 -
Importance and regulation of the colonic mucus barrier in a mouse model of
colitis.
J Petersson, O Schreiber, Gunnar C. Hansson, S J Gendler, A Velcich, J O Lundberg, S Roos, L Holm, M Phillipson
American journal of physiology. Gastrointestinal and liver physiology - 2011 -
Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon
mucus.
Durai B Subramani, Malin E V Johansson, Gunnar Dahlén, Gunnar C. Hansson
Beneficial microbes - 2010 -
Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis
model.
Malin E V Johansson, Jenny K Gustafsson, Karolina E Sjöberg, Joel Petersson, Lena Holm, Henrik Sjövall, Gunnar C. Hansson
PloS one - 2010 -
Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of
IgA1.
Yoshinao Wada, Anne Dell, Stuart M Haslam, Bérangère Tissot, Kévin Canis, Parastoo Azadi, Malin Bäckström, Catherine E Costello, Gunnar C. Hansson, Yoshiyuki Hiki, Mayumi Ishihara, Hiromi Ito, Kazuaki Kakehi, Niclas G. Karlsson, C E Hayes, Koichi Kato, Nana Kawasaki, Kay-Hooi Khoo, Kunihiko Kobayashi, Daniel Kolarich, Akihiro Kondo, Carlito Lebrilla, Miyako Nakano, Hisashi Narimatsu, Jan Novak, Milos V Novotny, Erina Ohno, Nicolle H Packer, Elizabeth Palaima, Matthew B Renfrow, Michiko Tajiri, Kristina A Thomsson, Hirokazu Yagi, Shin-Yi Yu, Naoyuki Taniguchi
Molecular & cellular proteomics - 2010 -
Enhanced Detection of Sialylated and Sulfated Glycans with Negative Ion Mode Nanoliquid Chromatography/Mass Spectrometry at High
pH.
Kristina A Thomsson, Malin Bäckström, Jessica Holmén Larsson, Gunnar C. Hansson, Hasse Karlsson
Analytical chemistry - 2010 -
Lactobacillus and Bifidobacterium species do not secrete protease that cleaves the MUC2 mucin which organises the colon
mucus
Durai B Subramani, MEV Johansson, Gunnar Dahlén, Gunnar C. Hansson
Beneficial Microbes - 2010 -
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of
bacteria.
Gunnar C. Hansson, Malin E V Johansson
Gut microbes - 2010 -
Sparkling water--bicarbonate for cervix and cystic
fibrosis.
Gunnar C. Hansson
The Journal of physiology - 2010 -
A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by
nanoLC/MSn.
Jessica Holmén Larsson, Hasse Karlsson, Henrik Sjövall, Gunnar C. Hansson
Glycobiology - 2009 -
Cervical mucins carry alpha(1,2)fucosylated glycans that partly protect from experimental vaginal
candidiasis.
Steven E Domino, Elizabeth A Hurd, Kristina A Thomsson, David M Karnak, Jessica Holmén Larsson, Elisabeth Thomsson, Malin Bäckström, Gunnar C. Hansson
Glycoconjugate journal - 2009 -
High-throughput and high-sensitivity nano-LC/MS and MS/MS for O-glycan
profiling.
Hasse Karlsson, Jessica Holmén Larsson, Kristina A Thomsson, Iris van Dijk Härd, Malin Bäckström, Gunnar C. Hansson
Methods in molecular biology (Clifton, N.J.) - 2009 -
Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp
protein.
Malin E V Johansson, Kristina A Thomsson, Gunnar C. Hansson
Journal of proteome research - 2009 -
Sensitive liquid chromatography-electrospray mass spectrometry allows for the analysis of the O-glycosylation of immunoprecipitated proteins from cells or tissues: application to MUC1 glycosylation in
cancer.
Malin Bäckström, Kristina A Thomsson, Hasse Karlsson, Gunnar C. Hansson
Journal of proteome research - 2009 -
Localization of O-glycans in MUC1 glycoproteins using electron-capture dissociation fragmentation mass
spectrometry.
Carina Sihlbom, Iris van Dijk Härd, Martin Lidell, Thomas Noll, Gunnar C. Hansson, Malin Bäckström
Glycobiology - 2009 -
Molecular evolution of specific human antibody against MUC1 mucin results in improved recognition of the antigen on tumor
cells.
Jonas Persson, Malin Bäckström, H Johansson, Karin Jirström, Gunnar C. Hansson, Mats Ohlin
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 2009 -
The gastric mucus layers: constituents and regulation of
accumulation.
Mia Phillipson, Malin E V Johansson, Johanna Henriksnäs, Joel Petersson, Sandra J. Gendler, Stellan Sandler, A Erik G Persson, Gunnar C. Hansson, Lena Holm
American journal of physiology. Gastrointestinal and liver physiology - 2008 -
The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small
intestine
Emily Malmberg, Thaher Pelaseyed, Åsa Petersson, Ursula E. Seidler, Hugo de Jonge, John R. Riordan, Gunnar C. Hansson
Biochemical Journal - 2008 -
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of
bacteria.
Malin E V Johansson, Mia Phillipson, Joel Petersson, Anna Velcich, Lena Holm, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2008 -
Mapping of the 45M1 epitope to the C-terminal cysteine-rich part of the human MUC5AC
mucin.
Martin Lidell, Jacques Bara, Gunnar C. Hansson
The FEBS journal - 2008 -
CD43 promotes cell growth and helps to evade FAS-mediated apoptosis in non-hematopoietic cancer cells lacking the tumor suppressors p53 or
ARF.
L Kadaja-Saarepuu, Sirle Laos, K Jääger, J Viil, A Balikova, M Lõoke, Gunnar C. Hansson, Toivo Maimets
Oncogene - 2008 -
Gel-forming mucins appeared early in metazoan
evolution.
Tiange Lang, Gunnar C. Hansson, Tore Samuelsson
Proceedings of the National Academy of Sciences of the United States of America - 2007 -
Large scale identification of proteins, mucins, and their O-glycosylation in the endocervical mucus during the menstrual
cycle.
Ylva Andersch-Björkman, Kristina A Thomsson, Jessica Holmén Larsson, Erling Ekerhovd, Gunnar C. Hansson
Molecular & cellular proteomics : MCP - 2007 -
Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin
expression.
Emily Malmberg, Karin Noaksson, Mia Phillipson, Malin E V Johansson, Marina Hinojosa-Kurtzberg, Lena Holm, Sandra J. Gendler, Gunnar C. Hansson
American journal of physiology. Gastrointestinal and liver physiology - 2006 -
An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming
mucins.
Tiange Lang, Gunnar C. Hansson, Tore Samuelsson
BMC genomics - 2006 -
Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1
mucin.
Bertil Macao, Denny Johansson, Gunnar C. Hansson, Torleif Härd
Nature structural & molecular biology - 2006 -
Cleavage in the GDPH sequence of the C-terminal cysteine-rich part of the human MUC5AC
mucin.
Martin Lidell, Gunnar C. Hansson
The Biochemical journal - 2006 -
Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus
gel.
Martin Lidell, Darcy M Moncada, Kris Chadee, Gunnar C. Hansson
Proceedings of the National Academy of Sciences of the United States of America - 2006 -
The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in humna breast
cancer
Robert Sewell, Malin Bäckström, Martin Dalziel, Steven Gschmeissner, Hasse Karlsson, Thomas Noll, Jochem Gätgens, Henrik Clausen, Gunnar C. Hansson, J. Burchell, Joyce Taylor-Papadimitriou
J Biol Chem - 2006 -
Inhibition of NF-kappaB activation and chemokine expression by the leukocyte glycoprotein, CD43, in colon cancer
cells.
Sirle Laos, Dan Baeckström, Gunnar C. Hansson
International journal of oncology - 2006 -
Internal repeat variability in mucin
sequences.
F N Braun, Gunnar C. Hansson
Biomacromolecules - 2006 -
Biosynthesis and Secretion of Mucins, Especially the MUC2 Mucin, in Relation to Cystic
Fibrosis
Gunnar C. Hansson, Malin E V Johansson, Martin Lidell
Advances in Experimental Medicine and Biology - 2005 -
A MUC1 tandem repeat reporter protein produced in CHO-K1 cells has sialylated core 1 O-glycans and becomes more densely glycosylated if coexpressed with polypeptide-GalNAc-T4
transferase
Fredrik J. Olson, Malin Bäckström, Hasse Karlsson, J. Burchell, Gunnar C. Hansson
Glycobiology - 2005 -
Gastrointestinal mucins of Fut2-null mice lack terminal fucosylation without affecting colonization by Candida
albicans.
Elizabeth A Hurd, Jessica Holmén, Gunnar C. Hansson, Steven E Domino
Glycobiology - 2005 -
Shedding and gamma-Secretase mediated intramembrane proteolysis of the mucin-type molecule
CD43
Christian X Andersson, Julia Fernandez-Rodriguez, Sirle Laos, Dan Baeckström, Gunnar C. Hansson, Christian Haass
Biochem J. - 2005 -
Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic
cells
Aurelia Rughetti, Ilenia Pellicciotta, Mauro Biffoni, Malin Bäckström, Thomas Link, Eric P Bennet, Henrik Clausen, Gunnar C. Hansson, J. Burchell, Luigi Frati, Joyce Taylor-Papadimitriou, Marianna Nuti
J Immunol - 2005 -
Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu
rubripes
Tiange Lang, Marina Alexandersson, Gunnar C. Hansson, Tore Samuelsson
Glycobiology - 2004 -
Mucins and their O-Glycans from human bronchial epithelial cell
cultures.
Jessica Holmén, Niclas G. Karlsson, Lubna H Abdullah, Scott H Randell, John K Sheehan, Gunnar C. Hansson, C William Davis
American journal of physiology. Lung cellular and molecular physiology - 2004 -
CD43 has a functional NLS, interacts with beta-catenin, and affects gene
expression
Christian X Andersson, Julia Fernandez-Rodriguez, Sirle Laos, Dan Baeckström, Rein Sikut, Anu Sikut, Gunnar C. Hansson
Biochem. Biophys. Res. Commun. - 2004 -
MUC1 can interact with adenomatous polyposis coli in breast
cancer
Christine L. Hattrup, Julia Fernandez-Rodriguez, Joyce A. Schroeder, Gunnar C. Hansson, Sandra J. Gendler
Biochem Biophys Res Commun. - 2004 -
Alternative splicing of the human MUC2
gene.
Lawrence R Sternberg, James C Byrd, Gunnar C. Hansson, Kai-Feng Liu, Robert S Bresalier
Archives of biochemistry and biophysics - 2004 -
Default biosynthesis pathway for blood group-related glycolipids in human small intestine as defined by structural identification of linear and branched glycosylceramides in a group O Le(a-b-)
nonsecretor.
Jonas Ångström, Thomas Larsson, Gunnar C. Hansson, Karl-Anders Karlsson, Stephen Henry
Glycobiology - 2004 -
Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein
Mint3.
Emily Malmberg, Christian X Andersson, Martina Gentzsch, Jey H Chen, April Mengos, Liying Cui, Gunnar C. Hansson, John R Riordan
Journal of cell science - 2004 -
Bioprocess development for the production of a recombinant MUC1 fusion protein expressed by CHO-K1 cells in protein-free
medium
Thomas Link, Malin Bäckström, Ros Graham, R Essers, K Zörner, Jochem Gätgens, J. Burchell, Joyce Taylor-Papadimitriou, Gunnar C. Hansson, Thomas Noll
J Biotechnol - 2004 -
Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient
mice.
A Marina Hinojosa-Kurtzberg, Malin E V Johansson, Cathy S Madsen, Gunnar C. Hansson, Sandra J Gendler
American journal of physiology. Gastrointestinal and liver physiology - 2003 -
An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory
pathway.
Martin Lidell, Malin E V Johansson, Gunnar C. Hansson
The Journal of biological chemistry - 2003 -
The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T
cells.
Martin Lidell, Malin E V Johansson, Matthias Mörgelin, Noomi Asker, James R Gum, Young S Kim, Gunnar C. Hansson
The Biochemical journal - 2003 -
Recombinant MUC1 mucin with a breast cancer-like O-glycosylation produced in large amounts in Chinese-hamster ovary
cells.
Malin Bäckström, Thomas Link, Fredrik J. Olson, Hasse Karlsson, Rosalind Graham, Gianfranco Picco, Joy Burchell, Joyce Taylor-Papadimitriou, Thomas Noll, Gunnar C. Hansson
The Biochemical journal - 2003 -
Glycomics - a complex
challenge
Gunnar C. Hansson
The Biochemist - 2003 -
CFTR och slem - viktiga delar i vårt
infektionsförsvar.
Gunnar C. Hansson
CF Bladet - 2003 -
Two glycosylation alterations of mouse intestinal mucins due to infection caused by the parasite Nippostrongylus
brasiliensis.
Jessica Holmén, Fredrik J. Olson, Hasse Karlsson, Gunnar C. Hansson
Glycoconjugate journal - 2002 -
The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core
fragment.
Klaus Godl, Malin E V Johansson, Martin Lidell, Matthias Mörgelin, Hasse Karlsson, Fredrik J. Olson, James R Gum, Young S Kim, Gunnar C. Hansson
The Journal of biological chemistry - 2002 -
Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite
infection.
Fredrik J. Olson, Malin E V Johansson, Karin Klinga-Levan, Danièle Bouhours, Lennart Enerbäck, Gunnar C. Hansson, Niclas G. Karlsson
The Journal of biological chemistry - 2002 -
The leukocyte antigen CD43 is expressed in different cell lines of nonhematopoietic
origin.
Julia Fernandez-Rodriguez, Christian X Andersson, Sirle Laos, Dan Baeckström, A Sikut, R Sikut, Gunnar C. Hansson
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 2002 -
The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and
diverse.
Kristina A Thomsson, Akraporn Prakobphol, Hakon Leffler, Molakala S Reddy, Michael J Levine, Susan J Fisher, Gunnar C. Hansson
Glycobiology - 2002 -
Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucalpha1-2
glycosyltransferase.
Kristina A Thomsson, Marina Hinojosa-Kurtzberg, Karin A Axelsson, Steven E Domino, John B Lowe, Sandra J Gendler, Gunnar C. Hansson
The Biochemical journal - 2002 -
Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of
mucins.
Magnus A. B. Axelsson, Niclas G. Karlsson, Daniella Steel, J Ouwendijk, Tommy Nilsson, Gunnar C. Hansson
Glycobiology - 2001 -
Tumor cell MUC1 and CD43 are glycosylated differently with sialyl-Lewis a and x epitopes and show variable interactions with E-selectin under physiological flow
conditions.
Julia Fernandez-Rodriguez, O Dwir, R Alon, Gunnar C. Hansson
Glycoconjugate journal - 2001 -
Identification of transient glycosylation alterations of sialylated mucin oligosaccharides during infection by the rat intestinal parasite Nippostrongylus
brasiliensis.
Niclas G. Karlsson, Fredrik J. Olson, Per-Åke Jovall, Ylva Andersch, Lennart Enerbäck, Gunnar C. Hansson
The Biochemical journal - 2000 -
Sequencing of sulfated oligosaccharides from mucins by liquid chromatography and electrospray ionization tandem mass
spectrometry.
Kristina A Thomsson, H Karlsson, Gunnar C. Hansson
Analytical chemistry - 2000 -
Detection of CD43 (leukosialin) in colon adenoma and adenocarcinoma by novel monoclonal antibodies against its intracellular
domain.
R Sikut, Christian X Andersson, A Sikut, Julia Fernandez-Rodriguez, Niclas G. Karlsson, Gunnar C. Hansson
International journal of cancer. Journal international du cancer - 1999 -
Liquid chromatography-electrospray mass spectrometry as a tool for the analysis of sulfated oligosaccharides from mucin
glycoproteins.
Kristina A Thomsson, Niclas G. Karlsson, Gunnar C. Hansson
Journal of chromatography. A - 1999 -
Lithium evokes a more pronounced natriuresis when administered orally than when given intravenously to salt-depleted
rats.
J Mu, Malin E V Johansson, Gunnar C. Hansson, Ove Lundgren
Pflügers Archiv : European journal of physiology - 1999 -
Lack of evidence for an immunosuppressive role for
MUC1.
S Paul, N Bizouarne, A Paul, M R Price, Gunnar C. Hansson, M P Kieny, R B Acres
Cancer immunology, immunotherapy : CII - 1999 -
O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular
bonds.
Magnus A. B. Axelsson, Noomi Asker, Gunnar C. Hansson
The Journal of biological chemistry - 1998 -
Deglycosylation by gaseous hydrogen fluoride of mucus glycoproteins immobilized on nylon membranes and in microtiter
wells.
Magnus A. B. Axelsson, Emil M. Hansson, Rein Sikut, Gunnar C. Hansson
Glycoconjugate journal - 1998 -
Human MUC5AC mucin dimerizes in the rough endoplasmic reticulum, similarly to the MUC2
mucin.
Noomi Asker, Magnus A. B. Axelsson, Sven-Olof Olofsson, Gunnar C. Hansson
The Biochemical journal - 1998 -
Different O-glycosylation of respiratory mucin glycopeptides from a patient with cystic
fibrosis.
Kristina A Thomsson, I Carlstedt, Niclas G. Karlsson, Hasse Karlsson, Gunnar C. Hansson
Glycoconjugate journal - 1998 -
Reactivity of antibodies with highly glycosylated MUC1 mucins from colon carcinoma cells and
bile.
R Sikut, A Sikut, K Zhang, Dan Baeckström, Gunnar C. Hansson
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1998 -
Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi
apparatus.
Noomi Asker, Magnus A. B. Axelsson, Sven-Olof Olofsson, Gunnar C. Hansson
The Journal of biological chemistry - 1998 -
Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand
activity.
A Prakobphol, Kristina A Thomsson, Gunnar C. Hansson, S D Rosen, M S Singer, N J Phillips, K F Medzihradszky, A L Burlingame, H Leffler, S J Fisher
Biochemistry - 1998 -
Binding of enterotoxigenic Escherichia coli to isolated enterocytes and intestinal
mucus.
A Helander, Gunnar C. Hansson, Ann-Mari Svennerholm
Microbial pathogenesis - 1997 -
Binding of human enterotoxigenic Escherichia coli expressing coli surface antigen 6 to rabbit intestinal enterocytes and
glycoproteins.
Anna Helander, Gunnar C. Hansson, Ann-Mari Svennerholm
Advances in experimental medicine and biology - 1997 -
The glycosylation of rat intestinal Muc2 mucin varies between rat strains and the small and large intestine. A study of O-linked oligosaccharides by a mass spectrometric
approach.
Niclas G. Karlsson, A Herrmann, Hasse Karlsson, Malin E V Johansson, I Carlstedt, Gunnar C. Hansson
The Journal of biological chemistry - 1997 -
Mucus glycoproteins from pig gastric mucosa: identification ofdifferent mucin populations from the surface
epithelium.
H Nordman, J R Davies, A Herrmann, Niclas G. Karlsson, Gunnar C. Hansson, I Carlstedt
The Biochemical journal - 1997 -
Glycosylation differences between pig gastric mucin populations: a comparative study of the neutral oligosaccharides using mass
spectrometry.
Niclas G. Karlsson, H Nordman, Hasse Karlsson, I Carlstedt, Gunnar C. Hansson
The Biochemical journal - 1997 -
Comparison of sialyl-Lewis a-carrying CD43 and MUC1 mucins secreted from a colon carcinoma cell line for E-selectin binding and inhibition of leukocyte
adhesion.
K Zhang, Dan Baeckström, Hans Brevinge, Gunnar C. Hansson
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1997 -
A MUC1 mucin secreted from a colon carcinoma cell line inhibits target cell lysis by natural killer
cells.
K Zhang, R Sikut, Gunnar C. Hansson
Cellular immunology - 1997 -
Colon adenoma and cancer cells aberrantly express the leukocyte-associated sialoglycoprotein
CD43.
R Sikut, O Nilsson, Dan Baeckström, Gunnar C. Hansson
Biochemical and biophysical research communications - 1997 -
Molecular characterization of the large heavily glycosylated domain glycopeptide from the rat small intestinal Muc2
mucin.
Niclas G. Karlsson, Malin E V Johansson, Noomi Asker, Hasse Karlsson, S J Gendler, I Carlstedt, Gunnar C. Hansson
Glycoconjugate journal - 1996 -
Sulphated mucin oligosaccharides from porcine small intestine analysed by four-sector tandem mass
spectrometry.
Niclas G. Karlsson, Hasse Karlsson, Gunnar C. Hansson
Journal of mass spectrometry : JMS - 1996 -
The transcripts of the apomucin genes MUC2, MUC4, and MUC5AC are large and appear as distinct
bands.
Dan Baeckström, Gunnar C. Hansson
Glycoconjugate journal - 1996 -
Secreted MUC1 mucins lacking their cytoplasmic part and carrying sialyl-Lewis a and x epitopes from a tumor cell line and sera of colon carcinoma patients can inhibit HL-60 leukocyte adhesion to E-selectin-expressing endothelial
cells.
K Zhang, Dan Baeckström, Hans Brevinge, Gunnar C. Hansson
Journal of cellular biochemistry - 1996 -
Distinct sub-populations of carcinoma-associated MUC1 mucins as detected by the monoclonal antibody 9H8 and antibodies against the sialyl-Lewis a and sialyl-Lewis x epitopes in the circulation of breast-cancer
patients.
R Sikut, K Zhang, Dan Baeckström, Gunnar C. Hansson
International journal of cancer. Journal international du cancer - 1996 -
Chromosomal mapping of three mucin genes in the
rat.
Karin Klinga-Levan, J R Gum, S J Gendler, Y Kim, Gunnar C. Hansson
Mammalian genome : official journal of the International Mammalian Genome Society - 1996 -
Expression of the leukocyte-associated sialoglycoprotein CD43 by a colon carcinoma cell
line
Dan Baeckström, K. Zhang, Noomi Asker, Ulla Rüetschi, M. Ek, Gunnar C. Hansson
Journal of Biological Chemistry - 1995 -
The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the 'insoluble' mucin of rat small
intestine.
Noomi Asker, Dan Baeckström, Magnus A. B. Axelsson, Ingemar Carlstedt, Gunnar C. Hansson
The Biochemical journal - 1995 -
Strategy for the investigation of O-linked oligosaccharides from mucins based on the separation into neutral, sialic acid- and sulfate-containing
species.
Niclas G. Karlsson, Hasse Karlsson, Gunnar C. Hansson
Glycoconjugate journal - 1995 -
Analysis of monosaccharide composition of mucin oligosaccharide alditols by high-performance anion-exchange
chromatography.
Niclas G. Karlsson, Gunnar C. Hansson
Analytical biochemistry - 1995 -
Structure and genetic polymorphism of blood group A-active glycosphingolipids of the rat large
intestine.
Danièle Bouhours, Gunnar C. Hansson, J F Bouhours
Biochimica et biophysica acta - 1995 -
Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4 and C4 generation by human leukocytes in
vitro.
T Shimizu, Sigurdur Kristjánsson, Göran Wennergren, Gunnar C. Hansson, Birgitta Strandvik
Pediatric pulmonology - 1994 -
Purification and characterization of sialyl-Le(a)-carrying mucins of human bile; evidence for the presence of MUC1 and MUC3
apoproteins.
Dan Baeckström, Niclas G. Karlsson, Gunnar C. Hansson
The Journal of biological chemistry - 1994 -
Molecular cloning of a cDNA coding for a region of an apoprotein from the 'insoluble' mucin complex of rat small
intestine.
Gunnar C. Hansson, Dan Baeckström, I Carlstedt, Karin Klinga-Levan
Biochemical and biophysical research communications - 1994 -
A secreted mucin carrying sialyl-Lewis a from colon carcinoma cells binds to E-selectin and inhibits HL-60 cell
adhesion.
K Zhang, Dan Baeckström, Gunnar C. Hansson
International journal of cancer. Journal international du cancer - 1994 -
Characterization of two different glycosylated domains from the insoluble mucin complex of rat small
intestine.
I Carlstedt, A Herrmann, Hasse Karlsson, J Sheehan, L A Fransson, Gunnar C. Hansson
The Journal of biological chemistry - 1993 -
Glycosphingolipid receptors for Pseudomonas
aeruginosa.
N Baker, Gunnar C. Hansson, Hakon Leffler, Gerdt C. Riise, Catharina Svanborg-Edén
Infection and immunity - 1990 -
Structures of blood group glycosphingolipids of human small intestine. A relation between the expression of fucolipids of epithelial cells and the ABO, Le and Se phenotype of the
donor.
S Björk, Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
The Journal of biological chemistry - 1987 -
Specificity of binding of a strain of uropathogenic Escherichia coli to Gal alpha 1----4Gal-containing
glycosphingolipids.
K Bock, Michael Breimer, A Brignole, Gunnar C. Hansson, K A Karlsson, G Larson, H Leffler, B E Samuelsson, N Strömberg, C S Edén
The Journal of biological chemistry - 1985 -
The specific glycosphingolipid composition of human ureteral epithelial
cells.
Michael Breimer, Gunnar C. Hansson, H Leffler
Journal of biochemistry - 1985 -
Blood group glycosphingolipids of human gastrointestinal
tissue.
S Björk, Michael Breimer, Gunnar C. Hansson, K-A Karlsson, H Leffler
Red cell membrane glycoconjugates and related genetics markers.(eds Catron JP, Rouger P, Salomon C) - 1983 -
Blood group glycosphingolipids of human
kidney.
Michael Breimer, Gunnar C. Hansson, G Larsson
Glycoconjugates (eds Chester, A, Heinegård D, Lundblad A, Svensson S). - 1983 -
Sequencing of large oligosaccharides by direct inlet mass spectrometry application to cell surface
glycolipids.
Michael Breimer, Gunnar C. Hansson, KA Karlsson, H Leiffler, W Pimlott, BE Samuelsson, N Strömberg, J Thurin
International Journal of Mass Spectrometry - 1983 -
The preparative separation of sialic acid-containing lipids from sulphate group-containing glycolipids from small intestine of different animals. Analysis by thin-layer chromatography and detection of novel
species.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Journal of biochemistry - 1983 -
Glycosphingolipids of rat tissues. Different composition of epithelial and nonepithelial cells of small
intestine.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
The Journal of biological chemistry - 1982 -
Isolation and partial characterization of blood group A and H active glycosphingolipids of rat small
intestine.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
The Journal of biological chemistry - 1982 -
Chemical characterization of penta-, hexa-, hepta-, octa-, and nonaglycosylceramides of rat small intestine having a globoside-like
terminus.
Jonas Ångström, Michael Breimer, K E Falk, Gunnar C. Hansson, K A Karlsson, H Leffler
The Journal of biological chemistry - 1982 -
Structural characterization of glycolipids of rat small intestine having one to eight hexoses in a linear
sequence.
Jonas Ångström, Michael Breimer, K E Falk, Gunnar C. Hansson, K A Karlsson, H Leffler, I Pascher
Archives of biochemistry and biophysics - 1982 -
Studies on differentiating epithelial cells of rat small intestine. Alterations in the lipophilic part of glycosphingolipids during cell migration from crypt villus
tip.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Biochimica et biophysica acta - 1982 -
Sequencing of oligosaccharides by mass spectrometry applied on a 12-sugar
glycolipid.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler, W Pimlott, B E Samuelsson
FEBS letters - 1981 -
Glycosphingolipids and the differentiation of intestinal
epithelium.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Experimental cell research - 1981 -
Blood group type glycosphingolipids from the small intestine of different animals analysed by mass spectrometry and thin-layer chromatography. A note on species
diversity.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Journal of biochemistry - 1981 -
Separation and characterization of hematosides with different sialic acids and ceramides from rat small intestine. Different composition of epithelial cells versus non-epithelial tissue and of duodenum versus
jejunum-ileum.
Jonas Ångström, Michael Breimer, K E Falk, I Griph, Gunnar C. Hansson, K A Karlsson, H Leffler
Journal of biochemistry - 1981 -
Glycolipids of rat small intenstine with special reference to ephitelial cells in relation to
differentiation.
Michael Breimer, Gunnar C. Hansson, KA Karlsson, H Leffler
Biochemistry of cell surface glycolipids. (eds Sweeley , CC) - 1980 -
Glycolipids of rat small intestine. Characterization of a novel blood group H-active
triglycosylceramide.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Biochimica et biophysica acta - 1980 -
Human blood group A-positive and -negative strains of rat. Chemical basis as shown by fucolipids of small
intestine.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
FEBS letters - 1980 -
Demonstration of complexity of the glycosphingolipid fraction of rat small
intestine.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler
Biochemical and biophysical research communications - 1980 -
Selected ion monitoring of glycospingolipid mixtures. Identification of several blood group type glycolipids in the small intestine of an individual
rabbit.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler, W Pimlott, B E Samuelsson
Biomedical mass spectrometry - 1979 -
Structure determination of blood group type glycolipids of cat small intestine by mass
fragmentography.
Michael Breimer, Gunnar C. Hansson, K A Karlsson, H Leffler, W Pimlott, B E Samuelsson
FEBS letters - 1978