Anders Jeppsson

Professor/ Chief Physician

Department of Molecular and Clinical Medicine

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About Anders Jeppsson

Professor, Group leader

Graduated from Linköping University 1989. Board certified physician 1992, specialist in cardiothoracic surgery 1997, senior consultant 2002. Research fellow Mayo Clinic 1997, PhD 1998, associate professor in cardiothoracic Surgery 2002, full professor 2008. Main supervisor for 12 and co-supervisor for 5 completed PhD projects.

Selected appointments:

Vice chairman, Swedish Association of Thoracic Surgery 2015-2016
Vice chairman, Swedish Heart Association 2007-2009 Chairman, SWEDEHEART-registry 2009-2011
Member, Swedish Heart-Lung Foundation’s Research Council 2010-2015
Associate Editor, European Journal of Heart Failure, 2004-2009 Member
Circulation editorial board 2016-ongoing.

Honors and Awards

Selected awards: C. Walton Lillehei Young Investigator Award. Scandinavian Association of Thoracic Surgery
Pfizer´s Fellowship i Cardiovasculaer Research
The Ingegärd and Viking Olov Björk Scholarship for Thoracic and Cardiovascular Research
Scandinavian Association of Thoracic Surgery

Main Research

Improving outcome after coronary artery bypass surgery: A translational approach

Coronary artery bypass grafting (CABG) is the recommended treatment for the majority of patients with advanced coronary artery disease. Approximately 2500 CABG procedures are performed in Sweden every year. The total annual number of CABG worldwide has been estimated to more than 700 000. Outcome after CABG has improved steadily over the decades but there is still a considerable early and late complication rate. Thirty-day mortality after CABG is around 2 % and the risk for severe complications like excessive bleeding, myocardial infarction, renal failure, and stroke is approximately 8-10%.

Late complications after CABG are mainly due to worsening of the underlying coronary artery disease, which may cause recurrence of angina, thromboembolic complications including myocardial infarction, and sudden death. Several factors, e.g. high age, impaired cardiac function, female gender, socioeconomic factors and secondary prevention have impact on the long-term results after CABG. The main objective of the group’s research is to reduce complications and improve outcome after cardiac surgery with special focus on 1. Prevention and treatment of perioperative bleeding complications, 2. Prevention of thromboembolic complications, 3. Impact of gender socioeconomic factors. To reach the objective, the group large pursues both large clinical randomized trials, epidemiological studies based on regional and national databases and registries, and mechanistic in-vivo and in-vitro studies. A biobank with blood and tissue samples from the heart collected during surgery has been established in collaboration with the Wallenberg laboratory.

Group members

Senior researchers

Anders Jeppsson
Birgitta Romlin
Martin Karlsson

Postdoctoral fellows

Susanne Nielsen
Emma C. Hansson
Carl Johan Malm

PhD students

Caroline Shams Hakimi
Sukhi Singh
Katarina Waldén
Fredrik Söderlund

Research nurses

Eva Berg
Eva Lysell
Anna Börjesson

Administrator

Caroline Ivarsson

Key publications

Hansson EC, Jideus L, Aberg B, Bjursten H, Dreifaldt M, Holmgren A, Ivert T, Nozohoor S, Barbu M, Svedjeholm R, Jeppsson A. Coronary artery bypass grafting-related complications in patients treated with ticagrelor or clopidogrel: A nationwide study. Eur Heart J. 37(2):189-97 (2016).
Malm CJ, Hansson EC, Åkesson J, Andersson M, Hesse C, Shams Hakimi C, Jeppsson A. Preoperative platelet function predicts perioperative bleeding complications in ticagrelor-treated cardiac surgery patients. Br J Anaesth. 17(3):309-15 (2016).
Romlin BS, Söderlund F, Wåhlander H, Nilsson B, Baghaei F, Jeppsson A. Perioperative monitoring of platelet function in paediatric cardiac surgery by thromboelastometry or platelet aggregometry? Br J Anaesth. 116(6):822-8 (2016).
Fröjd V, Jeppsson A. Re-exploration for bleeding and its association to mortality after cardiac surgery. Ann Thorac Surg. 102(1):109-17 (2016).
Jeppsson A, Waldén K, Roman-Emanuel C, Thimour-Bergström L, Karlsson M. Preoperative supplementation with fibrinogen concentrate in cardiac surgery: A randomized controlled study. Br J Anaesth. 116(2):208-14 (2016).
Romlin BS, Söderlund F, Wåhlander H, Nilsson B, Baghaei F, Jeppsson A. Platelet count and platelet function in paediatric cardiac surgery: A prospective observational study. Br J Anaesth. 113(5):847-54 (2014).
Waldén K, Jeppsson A, Nasic S, Backlund E, Karlsson M. Low preoperative fibrinogen plasma concentration is associated with excessive bleeding after cardiac operations. Ann Thorac Surg. 97(4):1199-206 (2014).
Chung SC, Gedeborg R, Owen N, James S, Jeppsson A, Wolfe C, Heuschmann P, Deanfield J, Timmis A, Jernberg T, Hemingway H. Acute myocardial infarction: a comparison of short-term survival in national outcome registries in Sweden and in the UK. Lancet. 383(9925):1305-12 (2014).
Hansson EC, Shams Hakimi C, Åström-Olsson K, Wallén H, Dellborg M, Hesse C, Albertsson P, Jeppsson A. Effects of ex vivo platelet transfusion on platelet aggregability in blood samples from coronary artery disease patients treated with acetylsalicylic acid, clopidogrel or ticagrelor. Br J Anaesth. 112(3):570-5 (2014).
Thimour-Bergström L, Roman-Emanuel C, Schersten H, Friberg Ö, Gudbjartsson T, Jeppsson A. Triclosan-coated sutures reduce surgical site infections after open vein harvesting in coronary artery bypass grafting patients: A randomized controlled trial. Eur J Cardiothor Surg. 44(5):506-11 (2013).