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Levent Akyürek
Professor/ Specialized Physician
Department of Laboratory MedicineAbout Levent Akyürek
Dr. Akyürek graduated from the Medical School, Dokuz Eylül University, Turkey in 1989 and then completed his PhD program at the Uppsala University in 1996. He worked as a postdoctoral fellow in the laboratory of Elizabeth G. Nabel at the University of Michigan and the National Institutes of Health, USA between 1997 and 2002. Dr. Akyürek became an associate professor of cell biology in 2004 and professor of pathology in 2014 at the University of Gothenburg. He currently acts as a reviewer on the editorial boards of several scientific journals in the field of vascular biology, transplantation immunology and molecular biology. He is also serving as consultant pathologist and cytologist with expertise in pulmonary/thorax and molecular pathology at the Sahlgrenska Hospital in Göteborg.
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Targeting cleavage of C-terminal fragment of cytoskeletal filamin A in
cancers.
Ozgur Cakici, Sashidar Bandaru, Grace Yankun Lee, Dyar Mustafa, Levent Akyürek
Cells - 2024 -
Pulmonary adenocarcinoma in situ and minimally invasive adenocarcinomas in European patients have less KRAS and more EGFR mutations compared to advanced
adenocarcinomas.
Jennie Petterson, Dyar Mustafa, Sashidar Bandaru, Ella Äng Eklund, Andreas Hallqvist, Volkan I. Sayin, Andréanne Gagné, Henrik Fagman, Levent Akyürek
International Journal of Molecular Sciences - 2024 -
Combinatory analysis of immune cell subsets and tumor-specific genetic variants predict clinical response to PD-1 blockade in patients with non-small cell lung
cancer
Nikita Dutta, Anna Rohlin, Ella A Eklund, Maria K Magnusson, Frida Nilsson, Levent Akyürek, Per Torstensson, Volkan I. Sayin, Anna Lundgren, Andreas Hallqvist, Sukanya Raghavan
Frontiers in Oncology - 2023 -
Filamin A increases aggressiveness of human
neuroblastoma.
Sashidar Bandaru, Bharat Prajapati, Prasanna Kumar Juvvuna, Sandor Dosa, Per Kogner, John I Johnsen, Chandrasekhar Kanduri, Levent Akyürek
Neuro-oncology Advances - 2022 -
PD-1 inhibitor therapy of basal cell carcinoma with pulmonary
metastasis.
I Johansson, Max Levin, Levent Akyürek, Roger Olofsson Bagge, Lars Ny
Journal of the European Academy of Dermatology and Venereology - 2022 -
KRAS mutations impact clinical outcome in metastatic non-small cell lung
cancer.
Ella A Eklund, Clotilde Wiel, Henrik Fagman, Levent Akyürek, Sukanya Raghavan, Jan Nyman, Andreas Hallqvist, Volkan I. Sayin
Cancers - 2022 -
Isolated eosinophilic myometritis: A case report of an extremely rare
phenomenon
Ghayeb Mohammad, Fairouz Rustom, Sofie Albinsson, Christine Wennerås, Levent Akyürek
International Journal of Gynecological Pathology - 2021 -
Intussusceptive angiogenesis in human metastatic malignant
melanoma.
Ankur Pandita, Matias Ekstrand, Sara Bjursten, Zhiyuan Zhao, Per Fogelstrand, Kristell Le Gal, Lars Ny, Martin O Bergo, Joakim Karlsson, Jonas A Nilsson, Levent Akyürek, Malin Levin, Jan Borén, Andrew J Ewald, Keith E Mostov, Max Levin
The American Journal of Pathology - 2021 -
Filamin A regulates cardiovascular
remodeling
Sashidar Bandaru, Chandu Ala, Alex-Xianghua Zhou, Levent Akyürek
International Journal of Molecular Sciences - 2021 -
Immune response after allogeneic transplantation of decellularized uterine scaffolds in the
rat.
Arvind M. Padma, Ahmed Baker Alshaikh, Min Jong Song, Randa R. Akouri, Levent Akyürek, Mihai Oltean, Mats Brännström, Mats Hellström
Biomedical Materials - 2021 -
Antioxidants promote intestinal tumor progression in
mice.
Zhiyuan V. Zou, Kristell Le Gal, Ahmed E El Zowalaty, Lara Pehlivanoglu, Viktor Garellick, Nadia Gul, Mohamed X Ibrahim, Per-Olof Bergh, Marcus Henricsson, Clotilde Wiel, Levent Akyürek, Martin Bergö, Volkan I. Sayin, Per Lindahl
Antioxidants - 2021 -
P–459 Ex vivo perfusion of whole ewe ovaries with follicular maturation for up to seven days: towards the development of an alternative fertility preservation
method
Panos Tsiartas, Constantina Mateoiu, Megshree Deshmukh, Debashish Banerjee, Arvind M. Padma, Tagrid Jar-Allah, Levent Akyürek, Ali Khatibi, Milan Milenkovic, F Gandolfi, Mats Hellström, P. Patrizio, Randa Racho El-Akouri
Human Reproduction Vol 36 Issue Supplement 1 - 2021 -
Lack of RAC1 in macrophages protects against
atherosclerosis.
Sashidar Bandaru, Chandu Ala, Matias Ekstrand, Murali K Akula, Matteo Pedrelli, Xi Liu, Göran Bergström, Liliana Håversen, Jan Borén, Martin O. Bergö, Levent Akyürek
PLoS One - 2020 -
Can a peritoneal conduit become an
artery?
Petter Davik, Zuzana Chabadova, Martin Altreuther, Ingeborg Leinan, Sashidar Bandaru, Levent Akyürek, Erney Mattsson
EJVES Vascular Forum - 2020 -
Pulmonary manifestations of systemic
karyomegaly.
Levent Akyürek, Aziz Hussein, Andrew G Nicholson, Nils-Johan Mauritz, Johan Mölne
Respiratory Medicine Case Reports - 2020 -
IGL-1 as a preservation solution in intestinal transplantation: a multicenter
experience.
Emilio Canovai, Mihai Oltean, Gustaf Herlenius, Levent Akyürek, Guido Trentadue, Gerard Dijkstra, Jan W Haveman, Andreas Pascher, Gert De Hertogh, Diethard Monbaliu, Jacques Pirenne, Laurens J Ceulemans
Transplant International - 2020 -
The impact of age and luminal preservation on the development of intestinal preservation injury in
rats
John M. Söfteland, Anna Casselbrant, Levent Akyürek, Mats Hellström, Mihai Oltean
Transplantation - 2020 -
Response by Akyürek et al to Letter Regarding Article, "Targeting Filamin A Reduces Macrophage Activity and
Atherosclerosis".
Levent Akyürek, Martin O. Bergö, Sashidar Bandaru
Circulation - 2019 -
Targeting filamin A reduces macrophage activity and
atherosclerosis.
Sashidar Bandaru, Chandu Ala, Reza Salimi, Murali K Akula, Matias Ekstrand, Sravani Devarakonda, Joakim Karlsson, Jimmy Van den Eynden, Göran Bergström, Max Levin, Jan Borén, Martin O. Bergö, Levent Akyürek
Circulation - 2019 -
Sense-antisense lncRNA pair encoded by locus 6p22.3 determines neuroblastoma susceptibility via the USP36-CHD7-SOX9 regulatory
axis
Tanmoy Mondal, Prasanna Kumar Juvvuna, Agnete Kirkeby, Sanhita Mitra, Subazini Thankaswamy Kosalai, Larissa Traxler, Falk Hertwig, Sara Wernig-Zorc, Caroline Miranda, Lily Deland, Christoph Bartenhagen, Ruth Volland, Deniz Bartsch, Sashidar Bandaru, Anne Engesser, Santhilal Subhash, Tommy Martinsson, Helena Carén, Levent Akyürek, Leo Kurian, Meena Kanduri, Maite Huarte, Per Kogner, Matthias Fischer, Chandrasekhar Kanduri
Cancer Cell - 2018 -
Blocking the cleavage of filamin A by calpain inhibitor decreases tumor cell
growth
Reza Salimi, Sashidar Bandaru, Sravani Devarakonda, Sevtap Gökalp, Chandu Ala, Ali Alvandian, Nilgün Yener, Levent Akyürek
Anticancer Research - 2018 -
Depletion of ATP and glucose in advanced human atherosclerotic
plaques
Matias Ekstrand, Emma Widell, Anna Hammar, Levent Akyürek, Martin Johansson, Björn Fagerberg, Göran Bergström, Malin Levin, Per Fogelstrand, Jan Borén, Max Levin
PLoS One - 2017 -
A review on traumatic diaphragmatic
rupture
Joel Lundgren, SH Mousavie, AR Negahi, B Nakhaei, G Varga, Hans Granhed, Levent Akyürek, M Hosseini, David Pazooki
Trauma and Emergency Care - 2017 -
Tidig forskningssatsning ger långsiktigt
engagemang.
Puja Shahrouki, Åsa Torinsson Naluai, Agneta Ekman, Eric Hanse, Olle Larkö, Levent Akyürek
Läkartidningen - 2017 -
Management of gunshot wounds in a scandinavian
hospital
Joel Lundgren, SH Mousavie, AR Negahi, Levent Akyürek, Hans Granhed, M Hosseini, David Pazooki
Trauma and Emergency Care - 2017 -
Spontaneous twin pregnancy with live births after cryopreservation and re-implantation of ovarian
tissue
Milan Milenkovic, Mats Brännström, Cesar Diaz-Garcia, Kersti Lundin, Ulrika Selleskog, Brita Söderlund, Ali Khatibi, Berit Gull, Hans Bokström, Constantina Mateoiu, Levent Akyürek, Ann Thurin-Kjellberg
Gynecological Surgery - 2017 -
Traumatic diaphragmatic ruptures: A 10-year retrospective
study
Joel Lundgren, SH Mousavie, AR Negahi, B Nakhaei, G Varga, Levent Akyürek, Hans Granhed, M Hosseini, David Pazooki
Trauma and Emergency Care - 2017 -
Emergency thoracotomy in a Swedish setting: A consecutive series of 45 patients from a Scandinavian trauma
hospital
Joel Beck, Hans Granhed, Levent Akyürek, David Pazooki
Journal of Trauma and Treatment - 2016 -
Antioxidants can increase melanoma metastasis in
mice.
Kristell Le Gal, Mohamed X Ibrahim, Clotilde Wiel, Volkan I. Sayin, Murali K Akula, Christin Karlsson, Martin Dalin, Levent Akyürek, Per Lindahl, Jonas A Nilsson, Martin Bergö
Science Translational Medicine - 2015 -
Deficiency of filamin A in endothelial cells impairs left ventricular remodeling after myocardial
infarction.
Sashidar Bandaru, Julia Grönros, Björn Redfors, Cağlar Cil, David Pazooki, Reza Salimi, Erik Larsson, Alex-Xianghua Zhou, Elmir Omerovic, Levent Akyürek
Cardiovascular Research - 2015 -
p110alpha hot spot mutations E545K and H1047R exert metabolic reprogramming independently of p110alpha kinase
activity
Aditi Chaudhari, Daniel Krumlinde, Annika Lundqvist, Levent Akyürek, Sashidar Bandaru, Kristina Skålen, Marcus Ståhlman, Jan Borén, Yvonne Wettergren, Katarina Ejeskär, Victoria Rotter Sopasakis
Molecular and Cellular Biology - 2015 -
The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal
differentiation.
Gaurav Kumar Pandey, Sanhita Mitra, Santhilal Subhash, Falk Hertwig, Meena Kanduri, Kankadeb Mishra, Susanne Fransson, Abiarchana Ganeshram, Tanmoy Mondal, Sashidar Bandaru, Malin Östensson, Levent Akyürek, Jonas Abrahamsson, Susan Pfeifer, Erik Larsson, Leming Shi, Zhiyu Peng, Matthias Fischer, Tommy Martinsson, Fredrik Hedborg, Per Kogner, Chandrasekhar Kanduri
Cancer Cell - 2014 -
Amanuensprogram lockar forskarintresserade i
Göteborg.
Levent Akyürek, Fredrik Hessulf, Ka-Wei Tang, Eric Hanse, Catharina Lindholm
Läkartidningen - 2014 -
Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of
VEGF-A
Sashidar Bandaru, Xianghua Zhou, Pegah Rouhi, Yan Zhang, Martin Bergö, Cao Yihai, Levent Akyürek
Oncogenesis - 2014 -
Hypoxia-induced and calpain-dependent cleavage of filamin-A regulates the hypoxic
response.
Xiaowei Zheng, Alex-Xianghua Zhou, Pegah Rouhi, Hidetaka Uramoto, Jan Borén, Yihai Cao, Teresa Pereira, Levent Akyürek, Lorenz Poellinger
Proceedings of the National Academy of Science of the United States of America - 2014 -
Dose-dependent cardioprotection of enkephalin analogue Eribis peptide 94 and cardiac expression of opioid receptors in a porcine model of ischaemia and
reperfusion
Lars O Karlsson, Niklas Bergh, Lizhen Li, E. Bissessar, I. Bobrova, G. J. Gross, Levent Akyürek, Lars Grip
European journal of pharmacology - 2012 -
Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in
mice
Rajesh K. Nallapalli, Mohamed X Ibrahim, Xianghua Zhou, Sashidar Bandaru, Sai Naresh Sunkara, Björn Redfors, David Pazooki, Yin Zhang, Jan Borén, Yihai Cao, Martin Bergö, Levent Akyürek
Molecular Cancer - 2012 -
Filamin A mediates HGF/c-MET signaling in tumor cell
migration.
Xianghua Zhou, Asli Toylu, Rajesh K. Nallapalli, Gisela M A Nilsson, Nese Atabey, Carl-Henrik Heldin, Jan Borén, Martin Bergö, Levent Akyürek
International journal of cancer. Journal international du cancer - 2011 -
Filamins in cell signaling, transcription and organ
development.
Xianghua Zhou, John H Hartwig, Levent Akyürek
Trends in Cell Biology - 2010 -
Deficiency of cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) accelerates atherogenesis in apolipoprotein E-deficient
mice.
Levent Akyürek, Manfred Boehm, Michelle Olive, Xianghua Zhou, Hong San, Elizabeth G Nabel
Biochemical and Biophysical Research Communications - 2010 -
Cyclosporine does not reduce myocardial infarct size in a porcine ischemia-reperfusion
model.
Lars O Karlsson, Xianghua Zhou, Erik Larsson, Karin Åström-Olsson, Chrichan Månsson, Levent Akyürek, Lars Grip
Journal of Cardiovascular Pharmacology and Therapeutics - 2010 -
Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in
vitro.
Fei Tian, Xianghua Zhou, Anke M Smits, Erik Larsson, Marie-José Goumans, Carl-Henrik Heldin, Jan Borén, Levent Akyürek
Biochemical and Biophysical Research Communications - 2010 -
A positive relationship between filamin and VEGF in patients with lung
cancer
Hidetaka Uramoto, Levent Akyürek, T Hanagiri
Anticancer Research - 2010 -
Differences in lesion severity and cellular composition between in vivo assessed upstream and downstream sides of human symptomatic carotid atherosclerotic
plaques
Björn Fagerberg, Mikael Ryndel, Josefin Kjelldahl, Levent Akyürek, Lars Rosengren, Lars Karlström, Göran Bergström, Fredrik J. Olson
Journal of Vascular Surgery - 2010 -
Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in
angiogenesis.
Fei Tian, Xianghua Zhou, Johannes Wikström, Helen Karlsson, Helen Sjöland, Li-Ming Gan, Jan Borén, Levent Akyürek
American Journal of Physiology. Heart and Circulatory Physiology - 2009 -
Up- and downstream structural differences in carotid plaque composition - implications for studies of human symptomatic carotid
plaques
Fredrik J. Olson, Levent Akyürek, Erney Mattsson, Olov Wiklund, Björn Fagerberg
Atherosclerosis Supplements - 2008 -
15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell
migration.
Kristina Danielsson Norén, Ellen Rydberg Knutsen, Madeleine Ingelsten, Levent Akyürek, Pernilla Jirholt, Christina Ullström, Gun-Britt Forsberg, Jan Borén, Olov Wiklund, Lillemor Mattsson Hultén
Atherosclerosis - 2008 -
Developmental origin of smooth muscle cells in the descending aorta in
mice.
Per Wasteson, Bengt R Johansson, Tomi Jukkola, Silke Breuer, Levent Akyürek, Juha Partanen, Per Lindahl
Development (Cambridge, England) - 2008 -
RhoA-dependent vascular smooth muscle cell-specific transcription: adding diaphanous formins to the
puzzle.
Erik Larsson, Xianghua Zhou, Levent Akyürek
Arteriosclerosis, Thrombosis, and Vascular Biology - 2007 -
Filamins in cardiovascular
development.
Xianghua Zhou, Jan Borén, Levent Akyürek
Trends in Cardiovascular Medicine - 2007 -
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular
development
Xianghua Zhou, Fei Tian, Johan Sandzen, R. Cao, E. Flaberg, L. Szekely, Y. Cao, Claes Ohlsson, Martin Bergö, Jan Borén, Levent Akyürek
Proc Natl Acad Sci U S A - 2007 -
Diverse origin of vascular smooth muscle cells in the
neointima
Xianghua Zhou, Caroline Beck, Jan Borén, Levent Akyürek
Anadolu Kardiyol Derg - 2005 -
Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future
challenges
Caroline Beck, Hidetaka Uramoto, Jan Borén, Levent Akyürek
Current Gene Therapies - 2004 -
Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous
system.
Franck Lemiale, Wing-pui Kong, Levent Akyürek, Xu Ling, Yue Huang, Bimal K Chakrabarti, Michael Eckhaus, Gary J Nabel
Journal of Virology - 2003 -
Gene transfer strategies to inhibit neointima
formation.
Martin F Crook, Levent Akyürek
Trends in Cardiovascular Medicine - 2003